Imperial College London

ProfessorDarrelFrancis

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3381d.francis Website

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

581 results found

Schlaich MP, Schmieder RE, Bakris G, Blankestijn PJ, Boehm M, Campese VM, Francis DP, Grassi G, Hering D, Katholi R, Kjeldsen S, Krum H, Mahfoud F, Mancia G, Messerli FH, Narkiewicz K, Parati G, Rocha-Singh KJ, Ruilope LM, Rump LC, Sica DA, Sobotka PA, Tsioufis C, Vonend O, Weber MA, Williams B, Zeller T, Esler MDet al., 2013, International Expert Consensus Statement Percutaneous Transluminal Renal Denervation for the Treatment of Resistant Hypertension, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 62, Pages: 2031-2045, ISSN: 0735-1097

Journal article

Jamil-Copley S, Linton N, Koa-Wing M, Kojodjojo P, Lim PB, Malcolme-Lawes L, Whinnett Z, Wright I, Davies W, Peters N, Francis DP, Kanagaratnam Pet al., 2013, Application of Ripple Mapping with an Electroanatomic Mapping System for Diagnosis of Atrial Tachycardias, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 24, Pages: 1361-1369, ISSN: 1045-3873

Journal article

Tarkin JM, Nijjer S, Sen S, Petraco R, Echavarria-Pinto M, Asress KN, Lockie T, Khawaja MZ, Mayet J, Hughes AD, Malik IS, Mikhail GW, Baker CS, Foale RA, Redwood S, Francis DP, Escaned J, Davies JEet al., 2013, Hemodynamic Response to Intravenous Adenosine and Its Effect on Fractional Flow Reserve Assessment Results of the Adenosine for the Functional Evaluation of Coronary Stenosis Severity (AFFECTS) Study, CIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol: 6, Pages: 654-661, ISSN: 1941-7640

Journal article

Sohaib SMA, Chen Z, Whinnett ZI, Bouri S, Dickstein K, Linde C, Hayes DL, Manisty CH, Francis DPet al., 2013, Meta-analysis of symptomatic response attributable to the pacing component of cardiac resynchronization therapy, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 15, Pages: 1419-1428, ISSN: 1388-9842

Journal article

Kousera CA, Nijjer SS, Torii R, Petraco R, Sen S, Foin N, Broyd C, Hughes AD, Xu YX, Francis DP, Davies JEet al., 2013, Patient-specific Coronary Stenoses Can Be Modeled Using a Combination of Optical Coherence Tomography and Flow Velocities to Accurately Predict Hyperaemic Pressure Gradients, 25th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B186-B186, ISSN: 0735-1097

Conference paper

Petraco R, van de Hoef TP, Nijjer SS, Sen S, Meuwissen M, Foale RA, Malik IS, Broyd C, Foin N, Mikhail G, van Lavieren MA, Francis DP, Echavarria-Pinto M, Escaned J, Hughes AD, Mayet J, Piek J, Davies JEet al., 2013, Identification of stenoses with high underlying coronary flow reserve from pressure-only measurements using baseline instant wave-free ratio (iFR) and hyperaemic fractional flow reserve (FFR), 25th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B190-B190, ISSN: 0735-1097

Conference paper

Kousera CA, Nijjer SS, Torii R, Petraco R, Sen S, Foin N, Broyd C, Hughes AD, Xu YX, Francis DP, Davies JEet al., 2013, Optical Coherence Tomography can be combined with angiography to create highly accurate patient-specific models of human coronary anatomy in a rapid automated manner, 25th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B195-B195, ISSN: 0735-1097

Conference paper

Barron AJ, Zaman N, Cole GD, Wensel R, Okonko DO, Francis DPet al., 2013, Systematic review of genuine versus spurious side-effects of beta-blockers in heart failure using placebo control: Recommendations for patient information, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 3572-3579, ISSN: 0167-5273

Journal article

Petraco R, Escaned J, Sen S, Nijjer S, Francis DP, Davies JEet al., 2013, How high can "accuracy" be for iFR (or IVUS, or SPECT or OCT...) if using fractional flow reserve as the gold standard? RESPONSE, EUROINTERVENTION, Vol: 9, Pages: 770-772, ISSN: 1774-024X

Journal article

Whinnett ZI, Francis DP, 2013, Cardiac Resynchronization Therapy Mechanisms in Atrial Fibrillation, HEART FAILURE CLINICS, Vol: 9, Pages: 475-+, ISSN: 1551-7136

Journal article

Cleland JG, Clark AL, Costanzo P, Francis DPet al., 2013, Diabetes, aliskiren, and heart failure: let's bring ASTRONAUT down to earth, EUROPEAN HEART JOURNAL, Vol: 34, Pages: 3097-3099, ISSN: 0195-668X

Journal article

Ponikowski P, Jankowska EA, 2013, Hypoglycaemia in diabetic patients: highly undesirable by cardiologists., Eur Heart J, Vol: 34, Pages: 3102-3105

Journal article

Finegold JA, Asaria P, Francis DP, 2013, Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 934-945, ISSN: 0167-5273

Journal article

Nowbar AN, Cole GD, Francis DP, 2013, The changing relative contribution of operator salary and hardware costs to echocardiography - A historical perspective, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 1641-1641, ISSN: 0167-5273

Journal article

Raphael CE, Kyriacou A, Jones S, Pabari P, Cole G, Baruah R, Hughes AD, Francis DPet al., 2013, Multinational evaluation of the interpretability of the iterative method of optimisation of AV delay for CRT, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 407-413, ISSN: 0167-5273

Journal article

Wensel R, Francis DP, Meyer FJ, Opitz CF, Bruch L, Halank M, Winkler J, Seyfarth H-J, Glaeser S, Blumberg F, Obst A, Dandel M, Hetzer R, Ewert Ret al., 2013, Incremental prognostic value of cardiopulmonary exercise testing and resting haemodynamics in pulmonary arterial hypertension, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 167, Pages: 1193-1198, ISSN: 0167-5273

Journal article

Kyriacou A, Wa MELK, Pabari PA, Unsworth B, Baruah R, Willson K, Peters NS, Kanagaratnam P, Hughes AD, Mayet J, Whinnett ZI, Francis DPet al., 2013, A systematic approach to designing reliable VV optimization methodology: Assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 167, Pages: 954-964, ISSN: 0167-5273

Journal article

Broyd CJ, Sen S, Mikhail GW, Francis DP, Mayet J, Davies JEet al., 2013, Myocardial ischemia in aortic stenosis: Insights from arterial pulse-wave dynamics after percutaneous aortic valve replacement, TRENDS IN CARDIOVASCULAR MEDICINE, Vol: 23, Pages: 185-191, ISSN: 1050-1738

Journal article

Tarkin J, Nijjer S, Sen S, Petraco R, Mayet J, Echavarria Pinto M, Redwood S, Francis D, Escaned J, Davies Jet al., 2013, The haemodynamic response to intravenous adenosine and its impact on fractional flow reserve: results of the AFFECTS (Adenosine For the Functional assEssment of Coronary sTenosis Severity) study, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 514-514, ISSN: 0195-668X

Conference paper

Foin N, Sen S, Petraco R, Nijjer S, Torii R, Kousera C, Broyd C, Mehta V, Xu Y, Mayet J, Hughes A, Di Mario C, Krams R, Francis D, Davies Jet al., 2013, Method for Percutaneously Introducing, and Removing, Anatomical Stenosis of Predetermined Severity In Vivo: The "Stenotic Stent", JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 6, Pages: 640-648, ISSN: 1937-5387

Journal article

Malcolme-Lawes LC, Juli C, Karim R, Bai W, Quest R, Lim PB, Jamil-Copley S, Kojodjojo P, Ariff B, Davies DW, Rueckert D, Francis DP, Hunter R, Jones D, Boubertakh R, Petersen SE, Schilling R, Kanagaratnam P, Peters NSet al., 2013, Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study, HEART RHYTHM, Vol: 10, Pages: 1184-1191, ISSN: 1547-5271

Journal article

Moraldo M, Bergamini C, Malaweera ASN, Dhutia NM, Pabari PA, Willson K, Baruah R, Manisty C, Davies JE, Xu XY, Hughes AD, Francis DPet al., 2013, A novel fully automated method for mitral regurgitant orifice area quantification, International Journal of Cardiology, Vol: 166, Pages: 688-695, ISSN: 1874-1754

Background: Effective regurgitant orifice area (EROA) in mitral regurgitation (MR) is difficult to quantify.Clinically it is measured using the proximal isovelocity surface area (PISA) method, which is intrinsicallynot automatable, because it requires the operator to manually identify the mitral valve orifice. We introducea new fully automated algorithm, (“AQURO”), which calculates EROA directly from echocardiographic colourM-mode data, without requiring operator input.Methods: Multiple PISA measurements were compared to multiple AQURO measurements in twenty patientswith MR. For PISA analysis, three mutually blinded observers measured EROA from the four stored videoloops. For AQURO analysis, the software automatically processed the colour M-mode datasets and analysedthe velocity field in the flow-convergence zone to extract EROA directly without any requirement for manualradius measurement.Results: Reproducibility, measured by intraclass correlation (ICC), for PISA was 0.80, 0.83 and 0.83 (for 3 observersrespectively). Reproducibility for AQURO was 0.97. Agreement between replicate measurements calculatedusing Bland-Altman standard deviation of difference (SDD) was 21,17 and 17mm2for the threerespective observers viewing independent video loops using PISA. Agreement between replicate measurementsfor AQURO was 6, 5 and 7mm2for automated analysis of the three pairs of datasets.Conclusions: By eliminating the need to identify the orifice location, AQURO avoids an important source ofmeasurement variability. Compared with PISA, it also reduces the analysis time allowing analysis and averagingof data from significantly more beats, improving the consistency of EROA quantification.AQURO, being fully automated, is a simple, effective enhancement for EROA quantification using standardechocardiographic equipment.

Journal article

Shun-Shin MJ, Francis DP, 2013, Why even more clinical research studies may be false: effect of asymmetrical handling of clinically unexpected values., PLoS One, Vol: 8, Pages: e65323-e65323, ISSN: 1932-6203

BACKGROUND: In medical practice, clinically unexpected measurements might be quite properly handled by the remeasurement, removal, or reclassification of patients. If these habits are not prevented during clinical research, how much of each is needed to sway an entire study? METHODS AND RESULTS: Believing there is a difference between groups, a well-intentioned clinician researcher addresses unexpected values. We tested how much removal, remeasurement, or reclassification of patients would be needed in most cases to turn an otherwise-neutral study positive. Remeasurement of 19 patients out of 200 per group was required to make most studies positive. Removal was more powerful: just 9 out of 200 was enough. Reclassification was most powerful, with 5 out of 200 enough. The larger the study, the smaller the proportion of patients needing to be manipulated to make the study positive: the percentages needed to be remeasured, removed, or reclassified fell from 45%, 20%, and 10% respectively for a 20 patient-per-group study, to 4%, 2%, and 1% for an 800 patient-per-group study. Dot-plots, but not bar-charts, make the perhaps-inadvertent manipulations visible. Detection is possible using statistical methods such as the Tadpole test. CONCLUSIONS: Behaviours necessary for clinical practice are destructive to clinical research. Even small amounts of selective remeasurement, removal, or reclassification can produce false positive results. Size matters: larger studies are proportionately more vulnerable. If observational studies permit selective unblinded enrolment, malleable classification, or selective remeasurement, then results are not credible. Clinical research is very vulnerable to "remeasurement, removal, and reclassification", the 3 evil R's.

Journal article

Barthel P, Wensel R, Bauer A, Mueller A, Wolf P, Ulm K, Huster KM, Francis DP, Malik M, Schmidt Get al., 2013, Respiratory rate predicts outcome after acute myocardial infarction: a prospective cohort study, EUROPEAN HEART JOURNAL, Vol: 34, Pages: 1644-1650, ISSN: 0195-668X

Journal article

Malcolme-Lawes LC, Lim PB, Wright I, Kojodjojo P, Koa-Wing M, Jamil-Copley S, Dehbi H-M, Francis DP, Davies DW, Peters NS, Kanagaratnam Pet al., 2013, Characterization of the Left Atrial Neural Network and its Impact on Autonomic Modification Procedures, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 6, Pages: 632-640, ISSN: 1941-3149

Journal article

Park CM, March K, Ghosh AK, Jones S, Coady E, Tuson C, Francis D, Mayet J, Tillin T, Chaturvedi N, Hughes ADet al., 2013, Left-Ventricular Structure in the Southall And Brent REvisited (SABRE) Study Explaining Ethnic Differences, HYPERTENSION, Vol: 61, Pages: 1014-+, ISSN: 0194-911X

Journal article

Petraco R, Escaned J, Francis DP, Davies JEet al., 2013, Challenging the need for hyperaemia REPLY, EUROINTERVENTION, Vol: 9, Pages: 167-168, ISSN: 1774-024X

Journal article

Barron AJ, Dhutia N, Hughes AD, Francis DP, Wensel Ret al., 2013, Test-retest repeatability of cardiopulmonary exercise test parameters in patients with cardiac or respiratory disease, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S297-S297, ISSN: 1388-9842

Journal article

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