Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology



+44 (0)20 7594 3381d.francis Website




Miss Juliet Holmes +44 (0)20 7594 5735




Block B Hammersmith HospitalHammersmith Campus






BibTex format

author = {Seligman, H and Shun-Shin, M and Vasireddy, A and Cook, C and Ahmad, Y and Howard, J and Sen, S and Al-Lamee, R and Nijjer, S and Chamie, D and Davies, J and Mayet, J and Francis, D and Petraco, R},
doi = {10.1136/openhrt-2018-000971},
journal = {Open Heart},
title = {Fractional flow reserve derived from microcatheters versus standard pressure wires: a stenosis-level meta-analysis},
url = {},
volume = {6},
year = {2019}

RIS format (EndNote, RefMan)

AB - Aims: To determine the agreement between sensor-tipped microcatheter (MC) and pressure wire (PW) derived Fractional Flow Reserve (FFR). Methods and results: Studies comparing FFR obtained from MC (FFRMC, Navvus Microcatheter System, ACIST Medical Systems, Minnesota, USA) versus standard PW (FFRPW) were identified and a meta-analysis of numerical and categorical agreement was performed. The relative levels of drift and device failure of MC and PW systems from each study were assessed. Six studies with 440 lesions (413 patients) were included. The mean overall bias between FFRMC and FFRPW was -0.029 (FFRMC lower). Bias and variance were greater for lesions with lower FFRPW (p <0.001). Using a cut-off of 0.80, 18% of lesions were re-classified by FFRMC versus FFRPW (with 15% being false-positives). The difference in reported drift between FFRPW and FFRMC was small. Device failure was more common with MC than PW (7.1% versus 2%). Conclusion: FFRMC systematically overestimates lesion severity, with increased bias in more severe lesions. Using FFRMC changes revascularisation guidance in approximately 1 out of every 5 cases. Pressure wire drift was similar between systems. Device failure was higher with MC.
AU - Seligman,H
AU - Shun-Shin,M
AU - Vasireddy,A
AU - Cook,C
AU - Ahmad,Y
AU - Howard,J
AU - Sen,S
AU - Al-Lamee,R
AU - Nijjer,S
AU - Chamie,D
AU - Davies,J
AU - Mayet,J
AU - Francis,D
AU - Petraco,R
DO - 10.1136/openhrt-2018-000971
PY - 2019///
SN - 2053-3624
TI - Fractional flow reserve derived from microcatheters versus standard pressure wires: a stenosis-level meta-analysis
T2 - Open Heart
UR -
UR -
VL - 6
ER -