Imperial College London

ProfessorDarrelFrancis

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3381d.francis Website

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moraldo:2012,
author = {Moraldo, M and Cecaro, F and Shun-Shin, M and Pabari, P and Davies, JE and Xu, XY and Hughes, AD and Manisty, C and Francis, DP},
journal = {Iinternational Journal of Cardiology},
title = {Evidence-based recommendations for PISA measurements in mitral regurgitation: systematic review, clinical and in-vitro study},
url = {http://www.internationaljournalofcardiology.com/article/S0167-5273(12)01542-2/abstract},
year = {2012}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BackgroundGuidelines for quantifying mitral regurgitation (MR) using “proximal isovelocity surface area” (PISA) instruct operators to measure the PISA radius from valve orifice to Doppler flow convergence “hemisphere”. Using clinical data and a physically-constructed MR model we (A) analyse the actually-observed colour Doppler PISA shape and (B) test whether instructions to measure a “hemisphere” are helpful.Methods and resultsIn part A, the true shape of PISA shells was investigated using three separate approaches. First, a systematic review of published examples consistently showed non-hemispherical, “urchinoid” shapes. Second, our clinical data confirmed that the Doppler-visualized surface is non-hemispherical. Third, in-vitro experiments showed that round orifices never produce a colour Doppler hemisphere.In part B, six observers were instructed to measure hemisphere radius rh and (on a second viewing) urchinoid distance (du) in 11 clinical PISA datasets; 6 established experts also measured PISA distance as the gold standard. rh measurements, generated using the hemisphere instruction significantly underestimated expert values (−28%, p<0.0005), meaning rh2 was underestimated by approximately 2-fold. du measurements, generated using the non-hemisphere instruction were less biased (+7%, p=0.03).Finally, frame-to-frame variability in PISA distance was found to have a coefficient of variation (CV) of 25% in patients and 9% in in-vitro data. Beat-to-beat variability had a CV of 15% in patients.ConclusionsDoppler-visualized PISA shells are not hemispherical: we should avoid advising observers to measure a hemispherical radius because it encourages underestimation of orifice area by approximately two-fold. If precision is needed (e.g. to detect changes reliably) multi-frame averaging is essential.
AU - Moraldo,M
AU - Cecaro,F
AU - Shun-Shin,M
AU - Pabari,P
AU - Davies,JE
AU - Xu,XY
AU - Hughes,AD
AU - Manisty,C
AU - Francis,DP
PY - 2012///
TI - Evidence-based recommendations for PISA measurements in mitral regurgitation: systematic review, clinical and in-vitro study
T2 - Iinternational Journal of Cardiology
UR - http://www.internationaljournalofcardiology.com/article/S0167-5273(12)01542-2/abstract
ER -