Publications
714 results found
Cook C, Cole G, Asaris P, et al., 2014, THE ANNUAL GLOBAL ECONOMIC BURDEN OF HEART FAILURE, HEART, Vol: 100, Pages: A28-A29, ISSN: 1355-6037
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- Citations: 2
Jabbour R, Shun-Shin M, Finegold J, et al., 2014, META-ANALYSIS IDENTIFYING THE SOURCE OF CONFLICT BETWEEN DIFFERENT TRIAL REPORTS ON THE EFFECT OF CRT IN HEART FAILURE WITH NARROW QRS COMPLEXES, HEART, Vol: 100, Pages: A23-A23, ISSN: 1355-6037
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- Citations: 1
Finegold J, Cazeau S, Sohaib SMA, et al., 2014, THE EFFECT OF ALTERING AV DELAY ON THE PRE-EJECTION PERIOD IN PATIENTS WITH BIVENTRICULAR PACEMAKERS, HEART, Vol: 100, Pages: A22-A22, ISSN: 1355-6037
Keene D, Shun-Shin M, Price C, et al., 2014, 108 The Observational HDL Hypothesis: A Useful Therapeutic Target? a Meta Analysis of 117,411 Patients in Randomised Controlled Trials., Heart, Vol: 100 Suppl 3, Pages: A62-A63
Epidemiological studies have shown HDL to be a prognostic marker. We undertook a meta-analysis to assess the benefit on cardiovascular outcomes for those patients on pharmacological interventions aimed at increasing HDL. Niacin, fibrates and cholesteryl ester transfer protein inhibitors (CETP-I) were identified as agents that raise HDL levels.
Kidher E, Harling L, Ashrafian H, et al., 2014, Pulse wave velocity and neutrophil gelatinase-associated lipocalin as predictors of acute kidney injury following aortic valve replacement, Journal of Cardiothoracic Surgery, Vol: 9, ISSN: 1749-8090
BackgroundAccurate prediction, early detection and treatment of acute kidney injury (AKI) are essential for improving post-operative outcomes. This study aimed to examine the role of aortic stiffness and neutrophil gelatinase-associated lipocalin (NGAL) as predictors of AKI or need for early medical renal intervention following aortic valve replacement (AVR).MethodsAortic pulse wave velocity and plasma NGAL were measured pre-operatively in recruited patients undergoing AVR for aortic stenosis (AS). Plasma NGAL was also measured at 3 and 18–24 hours after cardiopulmonary bypass (CPB). AKI was defined using RIFLE criteria. Early medical renal intervention included diuretics or dopamine infusion exclusively for renal causes.ResultsFifty-three patients aged 71 ± 9 years were included. Sixteen (30%) developed AKI (AKI-Yes) and 24 patients (45%) received early medical intervention (Intervention-Yes). There was no significant difference in the demographic, clinical or operative characteristics between the two groups for either outcome. PWV did not significantly correlate with AKI (r = 0.12, P = 0.13) or early intervention (r = 0.18, P = 0.18). At 3 h post-CPB, plasma NGAL was a much stronger predictor of both AKI and the need for early medical intervention than conventional markers such as creatinine (AKI: AUC 83%, 95% CI 0.70–0.95 vs. AUC 65%, 95% CI 0.47- 0.82; Medical intervention: AUC 84%, 95% CI 0.72–0.96 vs. AUC 56%, 95% CI 0.38–0.73). Post-CPB (3 hr) plasma NGAL was also significantly associated with AKI (r = 0.68, P < 0.001) at levels above 150 ng/ml; and significantly associated with early intervention (r = 0.64, P < 0.001) above 136 ng/ml. Simple linear regression showed no relationship between PWV and NGAL levels.ConclusionAortic PWV does not correlate significantly with pos
Ingle L, Rigby AS, Sloan R, et al., 2014, Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure, HEART, Vol: 100, Pages: 781-786, ISSN: 1355-6037
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- Citations: 17
Wensel R, Francis DP, 2014, Prognosis in patients with chronic heart failure: it's the way they breathe that matters, HEART, Vol: 100, Pages: 754-755, ISSN: 1355-6037
Cook CM, Cole G, Asaria P, et al., 2014, The annual global economic burden of heart failure, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 16, Pages: 184-184, ISSN: 1388-9842
Zolgharni M, Dhutia NM, Cole GD, et al., 2014, Automated Aortic Doppler Flow Tracing for Reproducible Research and Clinical Measurements, IEEE TRANSACTIONS ON MEDICAL IMAGING, Vol: 33, Pages: 1071-1082, ISSN: 0278-0062
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- Citations: 19
Park CM, Tillin T, March K, et al., 2014, Hyperglycemia Has a Greater Impact on Left Ventricle Function in South Asians Than in Europeans, Diabetes Care, Vol: 37, Pages: 1124-1131, ISSN: 1935-5548
OBJECTIVE Diabetes is associated with left ventricular (LV) diastolic and systolic dysfunction. South Asians may be at particular risk of developing LV dysfunction owing to a high prevalence of diabetes. We investigated the role of diabetes and hyperglycemia in LV dysfunction in a community-based cohort of older South Asians and white Europeans.RESEARCH DESIGN AND METHODS Conventional and Doppler echocardiography was performed in 999 participants (542 Europeans and 457 South Asians aged 58–86 years) in a population-based study. Anthropometry, fasting bloods, coronary artery calcification scoring, blood pressure, and renal function were measured.RESULTS Diabetes and hyperglycemia across the spectrum of HbA1c had a greater adverse effect on LV function in South Asians than Europeans (N-terminal-probrain natriuretic peptide β ± SE 0.09 ± 0.04, P = 0.01, vs. −0.04 ± 0.05, P = 0.4, P for HbA1c/ethnicity interaction 0.02), diastolic function (E/e′ 0.69 ± 0.12, P < 0.0001, vs. 0.09 ± 0.2, P = 0.6, P for interaction 0.005), and systolic function (s′ −0.11 ± 0.06, P = 0.04, vs. 0.14 ± 0.09, P = 0.1, P for interaction 0.2). Multivariable adjustment for hypertension, microvascular disease, LV mass, coronary disease, and dyslipidemia only partially accounted for the ethnic differences. Adverse LV function in diabetic South Asians could not be accounted for by poorer glycemic control or longer diabetes duration.CONCLUSIONS Diabetes and hyperglycemia have a greater adverse effect on LV function in South Asians than Europeans, incompletely explained by adverse risk factors. South Asians may require earlier and more aggressive treatment of their cardiometabolic risk factors to reduce risks of LV dysfunction.
Nowbar AN, Mielewczik M, Karavassilis M, et al., 2014, Discrepancies in autologous bone marrow stem cell trials and enhancement of ejection fraction (DAMASCENE): weighted regression and meta-analysis, British Medical Journal, Vol: 348, Pages: 1-9, ISSN: 1468-5833
Objective To investigate whether discrepancies in trials of use of bone marrow stem cells in patients with heart disease account for the variation in reported effect size in improvement of left ventricular function.Design Identification and counting of factual discrepancies in trial reports, and sample size weighted regression against therapeutic effect size. Meta-analysis of trials that provided sufficient information.Data sources PubMed and Embase from inception to April 2013.Eligibility for selecting studies Randomised controlled trials evaluating the effect of autologous bone marrow stem cells for heart disease on mean left ventricular ejection fraction.Results There were over 600 discrepancies in 133 reports from 49 trials. There was a significant association between the number of discrepancies and the reported increment in EF with bone marrow stem cell therapy (Spearman’s r=0.4, P=0.005). Trials with no discrepancies were a small minority (five trials) and showed a mean EF effect size of −0.4%. The 24 trials with 1-10 discrepancies showed a mean effect size of 2.1%. The 12 with 11-20 discrepancies showed a mean effect of size 3.0%. The three with 21-30 discrepancies showed a mean effect size of 5.7%. The high discrepancy group, comprising five trials with over 30 discrepancies each, showed a mean effect size of 7.7%.Conclusions Avoiding discrepancies is difficult but is important because discrepancy count is related to effect size. The mechanism is unknown but should be explored in the design of future trials because in the five trials without discrepancies the effect of bone marrow stem cell therapy on ejection fraction is zero.
Whinnett ZI, Sohaib SMA, Jones S, et al., 2014, British randomised controlled trial of AV and VV optimization ("BRAVO") study: rationale, design, and endpoints, BMC CARDIOVASCULAR DISORDERS, Vol: 14, ISSN: 1471-2261
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- Citations: 4
da Cunha RP, van de Hoef T, Nijjer S, et al., 2014, PROGNOSTIC INSIGHTS INTO THE UTILISATION OF INSTANTANEOUS WAVE-FREE RATIO (IFR) TO GUIDE CORONARY REVASCULARISATION: RESULTS OF THE JUSTIFY-CFR STUDY, A COMPARISON OF PRESSURE-ONLY INDICES AGAINST CORONARY FLOW RESERVE, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: A1507-A1507, ISSN: 0735-1097
Nijjer SS, van de Hoef T, da Cunha RP, et al., 2014, RESTING CORONARY BLOOD FLOW VELOCITY IS CONSTANT ACROSS ALL STENOSIS SEVERITIES: IMPLICATIONS FOR TANDEM LESION AND PULLBACK ASSESSMENT, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: A1610-A1610, ISSN: 0735-1097
Jarman JWE, Wong T, Kojodjojo P, et al., 2014, Organizational Index Mapping to Identify Focal Sources During Persistent Atrial Fibrillation, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 25, Pages: 355-363, ISSN: 1045-3873
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- Citations: 26
Barron A, Dhutia N, Mayet J, et al., 2014, Test-retest repeatability of cardiopulmonary exercise test variables in patients with cardiac or respiratory disease, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 21, Pages: 445-453, ISSN: 2047-4873
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- Citations: 34
Jones S, Shun-Shin MJ, Cole GD, et al., 2014, Applicability of the iterative technique for cardiac resynchronization therapy optimization: full-disclosure, 50-sequential-patient dataset of transmitral Doppler traces, with implications for future research design and guidelines, EUROPACE, Vol: 16, Pages: 541-550, ISSN: 1099-5129
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- Citations: 12
Finegold JA, Manisty CH, Goldacre B, et al., 2014, What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 21, Pages: 464-474, ISSN: 2047-4873
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- Citations: 151
Barron A, Dhutia N, Mayet J, et al., 2014, Response to editorial 'Reproducibility of cardiopulmonary exercise test variables: getting into an additional strength of the test', EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 21, Pages: 454-455, ISSN: 2047-4873
Foin N, Gutierrez-Chico JL, Nakatani S, et al., 2014, Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance Implications for the Management of Incomplete Stent Apposition, CIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol: 7, Pages: 180-189, ISSN: 1941-7640
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- Citations: 156
Shun-Shin MJ, Howard JP, Francis DP, 2014, Removing the hype from hypertension, BMJ-BRITISH MEDICAL JOURNAL, Vol: 348, ISSN: 1756-1833
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- Citations: 11
Nowbar AN, Cole GD, Shun-Shin MJ, et al., 2014, International RCT-based guidelines for use of preoperative stress testing and perioperative beta-blockers and statins in non-cardiac surgery, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 172, Pages: 138-143, ISSN: 0167-5273
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- Citations: 10
Howard JP, Cole GD, Sievert H, et al., 2014, Unintentional overestimation of an expected antihypertensive effect in drug and device trials: Mechanisms and solutions, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 172, Pages: 29-35, ISSN: 0167-5273
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- Citations: 29
Bouri S, Shun-Shin MJ, Cole GD, et al., 2014, Meta-analysis of secure randomised controlled trials of beta-blockade to prevent perioperative death in non-cardiac surgery, Heart, Vol: 100, Pages: 456-464, ISSN: 1355-6037
Background Current European and American guidelines recommend the perioperative initiation of a course of β-blockers in those at risk of cardiac events undergoing high- or intermediate-risk surgery or vascular surgery. The Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography (DECREASE) family of trials, the bedrock of evidence for this, are no longer secure. We therefore conducted a meta-analysis of randomised controlled trials of β-blockade on perioperative mortality, non-fatal myocardial infarction, stroke and hypotension in non-cardiac surgery using the secure data.Methods The randomised controlled trials of initiation of β-blockers before non-cardiac surgery were examined. Primary outcome was all-cause mortality at 30 days or at discharge. The DECREASE trials were separately analysed.Results Nine secure trials totalling 10 529 patients, 291 of whom died, met the criteria. Initiation of a course of β-blockers before surgery caused a 27% risk increase in 30-day all-cause mortality (p=0.04). The DECREASE family of studies substantially contradict the meta-analysis of the secure trials on the effect of mortality (p=0.05 for divergence). In the secure trials, β-blockade reduced non-fatal myocardial infarction (RR 0.73, p=0.001) but increased stroke (RR 1.73, p=0.05) and hypotension (RR 1.51, p<0.00001). These results were dominated by one large trial.Conclusions Guideline bodies should retract their recommendations based on fictitious data without further delay. This should not be blocked by dispute over allocation of blame. The well-conducted trials indicate a statistically significant 27% increase in mortality from the initiation of perioperative β-blockade that guidelines currently recommend. Any remaining enthusiasts might best channel their energy into a further randomised trial which should be designed carefully and conducted honestly.
Nijjer S, Petraco R, Sen S, et al., 2014, The change in coronary flow after percutaneous coronary intervention in physiologically defined coronary stenoses, LANCET, Vol: 383, Pages: 76-76, ISSN: 0140-6736
Cook C, Cole G, Asaria P, et al., 2014, The annual global economic burden of heart failure, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 171, Pages: 368-376, ISSN: 0167-5273
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- Citations: 537
Al-Lamee R, Broyd C, Parker J, et al., 2014, Influence of Gender on Clinical Outcomes Following Transcatheter Aortic Valve Implantation,from the UK Transcatheter Aortic Valve Implantation Registry and the National Institute for Cardiovascular Outcomes Research, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 113, Pages: 522-528, ISSN: 0002-9149
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- Citations: 40
Kyriacou A, Pabari PA, Mayet J, et al., 2014, Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 171, Pages: 144-152, ISSN: 0167-5273
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- Citations: 12
Petraco R, Escaned J, Nijjer S, et al., 2014, Fractional Flow Reserve: A Good or a Gold Standard? Reply, JACC-CARDIOVASCULAR INTERVENTIONS, Vol: 7, Pages: 228-229, ISSN: 1936-8798
Sutton R, Salukhe TV, Franzen-Mcmanus A-C, et al., 2014, Ivabradine in treatment of sinus tachycardia mediated vasovagal syncope, EUROPACE, Vol: 16, Pages: 284-288, ISSN: 1099-5129
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- Citations: 23
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