Publications
715 results found
Tarkin J, Nijjer S, Sen S, et al., 2013, The haemodynamic response to intravenous adenosine and its impact on fractional flow reserve: results of the AFFECTS (Adenosine For the Functional assEssment of Coronary sTenosis Severity) study, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 514-514, ISSN: 0195-668X
Foin N, Sen S, Petraco R, et al., 2013, Method for Percutaneously Introducing, and Removing, Anatomical Stenosis of Predetermined Severity In Vivo: The "Stenotic Stent", JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 6, Pages: 640-648, ISSN: 1937-5387
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- Citations: 3
Malcolme-Lawes LC, Juli C, Karim R, et al., 2013, Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study, HEART RHYTHM, Vol: 10, Pages: 1184-1191, ISSN: 1547-5271
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- Citations: 104
Francis DP, 2013, How easily can omission of patients, or selection amongst poorly-reproducible measurements, create artificial correlations? Methods for detection and implications for observational research design in cardiology, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 167, Pages: 102-113, ISSN: 0167-5273
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- Citations: 13
Moraldo M, Bergamini C, Malaweera ASN, et al., 2013, A novel fully automated method for mitral regurgitant orifice area quantification, International Journal of Cardiology, Vol: 166, Pages: 688-695, ISSN: 1874-1754
Background: Effective regurgitant orifice area (EROA) in mitral regurgitation (MR) is difficult to quantify.Clinically it is measured using the proximal isovelocity surface area (PISA) method, which is intrinsicallynot automatable, because it requires the operator to manually identify the mitral valve orifice. We introducea new fully automated algorithm, (“AQURO”), which calculates EROA directly from echocardiographic colourM-mode data, without requiring operator input.Methods: Multiple PISA measurements were compared to multiple AQURO measurements in twenty patientswith MR. For PISA analysis, three mutually blinded observers measured EROA from the four stored videoloops. For AQURO analysis, the software automatically processed the colour M-mode datasets and analysedthe velocity field in the flow-convergence zone to extract EROA directly without any requirement for manualradius measurement.Results: Reproducibility, measured by intraclass correlation (ICC), for PISA was 0.80, 0.83 and 0.83 (for 3 observersrespectively). Reproducibility for AQURO was 0.97. Agreement between replicate measurements calculatedusing Bland-Altman standard deviation of difference (SDD) was 21,17 and 17mm2for the threerespective observers viewing independent video loops using PISA. Agreement between replicate measurementsfor AQURO was 6, 5 and 7mm2for automated analysis of the three pairs of datasets.Conclusions: By eliminating the need to identify the orifice location, AQURO avoids an important source ofmeasurement variability. Compared with PISA, it also reduces the analysis time allowing analysis and averagingof data from significantly more beats, improving the consistency of EROA quantification.AQURO, being fully automated, is a simple, effective enhancement for EROA quantification using standardechocardiographic equipment.
Shun-Shin MJ, Francis DP, 2013, Why even more clinical research studies may be false: effect of asymmetrical handling of clinically unexpected values., PLoS One, Vol: 8, Pages: e65323-e65323, ISSN: 1932-6203
BACKGROUND: In medical practice, clinically unexpected measurements might be quite properly handled by the remeasurement, removal, or reclassification of patients. If these habits are not prevented during clinical research, how much of each is needed to sway an entire study? METHODS AND RESULTS: Believing there is a difference between groups, a well-intentioned clinician researcher addresses unexpected values. We tested how much removal, remeasurement, or reclassification of patients would be needed in most cases to turn an otherwise-neutral study positive. Remeasurement of 19 patients out of 200 per group was required to make most studies positive. Removal was more powerful: just 9 out of 200 was enough. Reclassification was most powerful, with 5 out of 200 enough. The larger the study, the smaller the proportion of patients needing to be manipulated to make the study positive: the percentages needed to be remeasured, removed, or reclassified fell from 45%, 20%, and 10% respectively for a 20 patient-per-group study, to 4%, 2%, and 1% for an 800 patient-per-group study. Dot-plots, but not bar-charts, make the perhaps-inadvertent manipulations visible. Detection is possible using statistical methods such as the Tadpole test. CONCLUSIONS: Behaviours necessary for clinical practice are destructive to clinical research. Even small amounts of selective remeasurement, removal, or reclassification can produce false positive results. Size matters: larger studies are proportionately more vulnerable. If observational studies permit selective unblinded enrolment, malleable classification, or selective remeasurement, then results are not credible. Clinical research is very vulnerable to "remeasurement, removal, and reclassification", the 3 evil R's.
Barthel P, Wensel R, Bauer A, et al., 2013, Respiratory rate predicts outcome after acute myocardial infarction: a prospective cohort study, EUROPEAN HEART JOURNAL, Vol: 34, Pages: 1644-1650, ISSN: 0195-668X
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- Citations: 58
Malcolme-Lawes LC, Lim PB, Wright I, et al., 2013, Characterization of the Left Atrial Neural Network and its Impact on Autonomic Modification Procedures, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 6, Pages: 632-640, ISSN: 1941-3149
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- Citations: 40
Park CM, March K, Ghosh AK, et al., 2013, Left-Ventricular Structure in the Southall And Brent REvisited (SABRE) Study Explaining Ethnic Differences, HYPERTENSION, Vol: 61, Pages: 1014-+, ISSN: 0194-911X
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- Citations: 26
Petraco R, Escaned J, Francis DP, et al., 2013, Challenging the need for hyperaemia REPLY, EUROINTERVENTION, Vol: 9, Pages: 167-168, ISSN: 1774-024X
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- Citations: 1
Barron AJ, Dhutia N, Hughes AD, et al., 2013, Test-retest repeatability of cardiopulmonary exercise test parameters in patients with cardiac or respiratory disease, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 12, Pages: S297-S297, ISSN: 1388-9842
Petraco R, Sen S, Nijjer SS, et al., 2013, FFR-GUIDED CORONARY REVASCULARISATION: IMPLICATIONS OF ITS BIOLOGICAL VARIABILITY ON CLINICAL DECISIONS, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, ISSN: 1355-6037
Nijjer SSS, Sen S, Petraco R, et al., 2013, INSTANTANEOUS WAVE-FREE RATIO (IFR) CAN DETECT IMPROVEMENT IN CORONARY STENOSIS SEVERITY AFTER PERCUTANEOUS INTERVENTION, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, Pages: A37-A37, ISSN: 1355-6037
Unsworth B, Casula RP, Yadav H, et al., 2013, Contrasting effect of different cardiothoracic operations on echocardiographic right ventricular long axis velocities, and implications for interpretation of post-operative values, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 165, Pages: 151-160, ISSN: 0167-5273
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- Citations: 41
Dehbi H-M, Francis DP, 2013, A 64,489-patient full-disclosure database of cardiovascular risk factors and events status analysed in a Bayesian framework: A unique contribution to predictive science, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 165, Pages: 3-6, ISSN: 0167-5273
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- Citations: 1
Sen S, Nijjer S, Petraco R, et al., 2013, The Effect of Adenosine on Coronary Microvascular Resistance Is More Consistent During the Diastolic Wave-free Period: Should We Continue to Use the Complete Cardiac Cycle for Stenosis Assessment?, 18th Angioplasty Summit Transcatheter Cardiovascular Therapeutics Asia Pacific (TCTAP), Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 100B-101B, ISSN: 0002-9149
Petraco R, Park JJ, Sen S, et al., 2013, Hybrid Ifr-FFR Decision-Making Strategy: Implications for Enhancing Universal Adoption of Physiology-Guided Coronary Revascularization., 18th Angioplasty Summit Transcatheter Cardiovascular Therapeutics Asia Pacific (TCTAP), Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 54B-54B, ISSN: 0002-9149
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- Citations: 4
Petraco R, Sen S, Nijjer S, et al., 2013, Implications of The Biological Variability of Fractional Flow Reserve on Coronary Revascularization Decisions., 18th Angioplasty Summit Transcatheter Cardiovascular Therapeutics Asia Pacific (TCTAP), Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 51B-51B, ISSN: 0002-9149
Foin N, Di Mario C, Francis DP, et al., 2013, Stent flexibility versus concertina effect: Mechanism of an unpleasant trade-off in stent design and its implications for stent selection in the cath-lab, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 164, Pages: 259-261, ISSN: 0167-5273
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- Citations: 15
Hughes AD, Park C, Davies J, et al., 2013, Limitations of augmentation index in the assessment of wave reflection in normotensive healthy individuals, PLOS One, Vol: 8, ISSN: 1932-6203
ObjectivesAugmentation index (AIx) is widely used as a measure of wave reflection. We compared the relationship between AIx and age, height and sex with ‘gold standard’ measures of wave reflection derived from measurements of pressure and flow to establish how well AIx measures wave reflection.Materials and MethodsMeasurements of carotid pressure and flow velocity were made in the carotid artery of 65 healthy normotensive individuals (age 21–78 yr; 43 male) and pulse wave analysis, wave intensity analysis and wave separation was performed; waveforms were classified into type A, B or C. AIx, the time of the first shoulder (Ts), wave reflection index (WRI) and the ratio of backward to forward pressure (Pb/Pf) were calculated.ResultsAIx did not correlate with log WRI or Pb/Pf. When AIx was restricted to positive values AIx and log WRI were positively correlated (r = 0.33; p = 0.04). In contrast log WRI and Pb/Pf were closely correlated (r = 0.66; p<0.001). There was no correlation between the Ts and the timing of Pb or the reflected wave identified by wave intensity analysis. Wave intensity analysis showed that the morphology of type C waveforms (negative AIx) was principally due to a forward travelling (re-reflected) decompression wave in mid-systole. AIx correlated positively with age, inversely with height and was higher in women. In contrast log WRI and Pb/Pf showed negative associations with age, were unrelated to height and did not differ significantly by gender.ConclusionsAIx has serious limitations as a measure of wave reflection. Negative AIx values derived from Type C waves should not be used as estimates of wave reflection magnitude.
Barakat MF, Chehab O, Hayat S, et al., 2013, ATTENUATIONS IN TISSUE DOPPLER-DERIVED LEFT VENTRICULAR SYSTOLIC VELOCITY PREDICT AN AMPLIFIED RISK OF LETHAL ARRHYTHMIAS IN ICD RECIPIENTS INDEPENDENTLY OF EJECTION FRACTION, 62nd Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: E818-E818, ISSN: 0735-1097
Turner HK, Norrington K, Barakat MF, et al., 2013, EVOLUTION OF ERYTHROCYTE INDICES TOWARD AN IRON DEFICIENT PICTURE PREDICTS EARLY MORTALITY IN ACUTE DECOMPENSATED HEART FAILURE, 62nd Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: E625-E625, ISSN: 0735-1097
Francis DP, 2013, How to reliably deliver narrow individual-patient error bars for optimization of pacemaker AV or VV delay using a "pick-the-highest" strategy with haemodynamic measurements, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 163, Pages: 221-225, ISSN: 0167-5273
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- Citations: 13
Whinnett ZI, Francis DP, Denis A, et al., 2013, Comparison of different invasive hemodynamic methods for AV delay optimization in patients with cardiac resynchronization therapy: Implications for clinical trial design and clinical practice, International Journal of Cardiology, Vol: 168, Pages: 2228-2237, ISSN: 1874-1754
Blessing E, Esler MD, Francis DP, et al., 2013, Cardiac ablation and renal denervation systems have distinct purposes and different technical requirements., JACC Cardiovasc Interv, Vol: 6
Kyriacou A, Whinnett ZI, Davies JE, et al., 2013, First-in-man evidence of the mechanistic effects of biventricular pacing on coronary physiology, Spring Meeting for Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 62-62, ISSN: 0140-6736
Davies JE, Manisty CH, Petraco R, et al., 2013, First-in-man safety evaluation of renal denervation for chronic systolic heart failure: Primary outcome from REACH-Pilot study, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 162, Pages: 189-192, ISSN: 0167-5273
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- Citations: 206
Malcolme-Lawes LC, Lim PB, Koa-Wing M, et al., 2013, Robotic assistance and general anaesthesia improve catheter stability and increase signal attenuation during atrial fibrillation ablation, EUROPACE, Vol: 15, Pages: 41-47, ISSN: 1099-5129
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- Citations: 18
Sen S, Nijjer S, Petraco R, et al., 2013, Instantaneous Wave-Free Ratio, Journal of the American College of Cardiology, Vol: 62, ISSN: 0735-1097
Foin N, Alegria E, Sen S, et al., 2013, Importance of knowing stent design threshold diameters and post-dilatation capacities to optimise stent selection and prevent stent overexpansion/incomplete apposition during PCI, International journal of cardiology, Vol: 166, Pages: 755-758, ISSN: 1874-1754
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