Imperial College London

ProfessorDarrelFrancis

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3381d.francis Website

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

715 results found

Davies JE, Sen S, Hadjiloizou N, Francis DP, Foale RA, Mayet J, Parker KH, Hughes AD, Chukwuemeka A, Mikhail G, Malik ISet al., 2010, ACUTE CHANGES IN CORONARY HAEMODYNAMIC IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE IMPLANTATION, Annual Conference and Exhibition of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A59-A59, ISSN: 1355-6037

Conference paper

Baksi AJ, Treibel TA, Davies JE, Hadjiloizou N, Foale RA, Parker KH, Francis DP, Mayet J, Hughes ADet al., 2010, Changes in the Central Arterial Pressure Pulse With Aging Reply, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 2183-2184, ISSN: 0735-1097

Journal article

Salukhe TV, Briceno NI, Ferenczi EA, Sutton R, Francis DPet al., 2010, Is there benefit in implanting defibrillators in patients with severe heart failure?, HEART, Vol: 96, Pages: 599-603, ISSN: 1355-6037

Journal article

Dimopoulos K, Diller G-P, Petraco R, Koltsida E, Giannakoulas G, Tay EL, Best N, Piepoli MF, Francis DP, Poole-Wilson PA, Gatzoulis MAet al., 2010, Hyponatraemia: a strong predictor of mortality in adults with congenital heart disease, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 595-601, ISSN: 0195-668X

Journal article

Sharp ASP, Tapp RJ, Thom SAM, Francis DP, Hughes AD, Stanton AV, Zambanini A, O'Brien E, Chaturvedi N, Lyons S, Byrd S, Poulter NR, Sever PS, Mayet Jet al., 2010, Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 747-752, ISSN: 0195-668X

Journal article

Raphael C, Kanagaratnam P, Francis DP, 2010, Further Barriers to Conversations About Deactivation of Implantable Cardioverter-Defibrillators, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 701-702, ISSN: 0735-1097

Journal article

Yadav H, Unsworth B, Fontana M, Diller G-P, Kyriacou A, Baruah R, Mayet J, Francis DFet al., 2010, Selective right ventricular impairment following coronary artery bypass graft surgery, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 37, Pages: 393-398, ISSN: 1010-7940

Journal article

Unsworth B, Casula RP, Kyriacou AA, Yadav H, Chukwuemeka A, Cherian A, Stanbridge RDL, Athanasiou T, Mayet J, Francis DPet al., 2010, The right ventricular annular velocity reduction caused by coronary artery bypass graft surgery occurs at the moment of pericardial incision, AMERICAN HEART JOURNAL, Vol: 159, ISSN: 0002-8703

Journal article

Diller G-P, Lammers AE, Haworth SG, Dimopoulos K, Derrick G, Bonhoeffer P, Gatzoulis MA, Francis DPet al., 2010, A modelling study of atrial septostomy for pulmonary arterial hypertension, and its effect on the state of tissue oxygenation and systemic blood flow, CARDIOLOGY IN THE YOUNG, Vol: 20, Pages: 25-32, ISSN: 1047-9511

Journal article

Davies JE, Baksi J, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Foale RA, Malik IS, Tyberg JV, Parker KH, Mayet J, Hughes ADet al., 2010, The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 298, Pages: H580-H586, ISSN: 0363-6135

Journal article

Davies JE, Shanmuganathan M, Francis DP, Mayet J, Hackett DR, Hughes ADet al., 2010, Caution Using Brachial Systolic Pressure to Calibrate Radial Tonometric Pressure Waveforms: Lessons From Invasive Study, HYPERTENSION, Vol: 55, Pages: E4-E4, ISSN: 0194-911X

Journal article

Barron AJ, Medlow KI, Giannoni A, Unsworth B, Coats AJS, Mayet J, Howard LS, Francis DPet al., 2010, Reduced confounding by impaired ventilatory function with oxygen uptake efficiency slope and VE/VCO2 slope rather than peak oxygen consumption to assess exercise physiology in suspected heart failure., Congest Heart Fail, Vol: 16, Pages: 259-264

Heart failure and ventilatory disease often coexist; both create abnormalities in cardiopulmonary exercise test measurements. The authors evaluated the relative dependency of a well-recognized index of heart failure, peak oxygen consumption (VO(2)), and 2 newer indices, the minute ventilation (VE)/carbon dioxide production (VCO(2)) slope and oxygen uptake efficiency slope (OUES), on standard markers of impaired cardiac and ventilatory function. One hundred twenty-four patients (median age, 65.8; range, 22.6-84.9), with functional limitation from clinical heart failure were exercised. Peak VO(2) was 17.14 ± 7.58 mL/kg/min, VE/VCO(2) slope 50.1 ± 20.1, OUES 1.46 ± 0.68 L/min, and forced expiratory volume in 1 second (FEV(1) ) 1.88 ± 0.75 L. Peak VO(2) is substantially more sensitive to FEV(1) than ejection fraction (4.0 mL/kg/min difference between above- and below-median FEV(1) and 1.5 mL/kg/min between above- and below-median ejection fraction). OUES does not share this peculiar excess sensitivity to FEV(1) (0.12 L/min difference between above- and below-median FEV(1) and 0.01 L/min between above- and below-median ejection fraction). VE/VCO(2) slope has a borderline effect by FEV(1) (7.07 difference between above- and below-median FEV(1) and 2.07 between above- and below-median ejection fraction). Although widely used as a marker of heart failure severity, peak VO(2) is very sensitive to spirometry status and is indeed more affected by FEV(1) than by ejection fraction. OUES in contrast does not show this preferential sensitivity to impaired FEV(1).

Journal article

Davies JE, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Malik IS, Parker KH, Hughes AD, Mayet Jet al., 2010, Augmentation of Coronary Blood Flow in Systole by Reflected Waves in the Proximal Aorta, 11th International Congress of the IUPESM/World Congress on Medical Physics and Biomedical Engineering, Publisher: SPRINGER, Pages: 61-64, ISSN: 1680-0737

Conference paper

Linton NWF, Koa-Wing M, Francis DP, Kojodjojo P, Lim PB, Salukhe TV, Whinnett Z, Davies DW, Peters NS, O'Neill MD, Kanagaratnam Pet al., 2009, Cardiac ripple mapping: A novel three-dimensional visualization method for use with electroanatomic mapping of cardiac arrhythmias, HEART RHYTHM, Vol: 6, Pages: 1754-1762, ISSN: 1547-5271

Journal article

Ponikowska B, Jankowska EA, Reczuch K, Wegrzynowska-Teodorczyk K, Witkowski T, Rydlewska A, Borodulin-Nadzieja L, Banasiak W, Francis D, Ponikowski Pet al., 2009, Abnormal indices of autonomic function are no longer predictors of poor outcome in diabetic patients without neuropathy but with coexisting coronary artery disease who receive optimal pharmacological therapy, KARDIOLOGIA POLSKA, Vol: 67, Pages: 1325-1334, ISSN: 0022-9032

Journal article

Dimopoulos K, Diller G-P, Giannakoulas G, Petraco R, Chamaidi A, Karaoli E, Mullen M, Swan L, Piepoli MF, Poole-Wilson PA, Francis DP, Gatzoulis MAet al., 2009, Anemia in Adults With Congenital Heart Disease Relates to Adverse Outcome, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 54, Pages: 2093-2100, ISSN: 0735-1097

Journal article

Baksi AJ, Treibel TA, Davies JE, Hadjiloizou N, Foale RA, Parker KH, Francis DP, Mayet J, Hughes ADet al., 2009, A Meta-Analysis of the Mechanism of Blood Pressure Change With Aging, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 54, Pages: 2087-2092, ISSN: 0735-1097

Journal article

Jarman JW, Wong T, Francis DP, Davies DW, Kanagaratnam P, Markides V, Peters NSet al., 2009, Spatiotemporal Behaviour of High Dominant Frequency During Paroxysmal and Persistent Atrial Fibrillation in the Human Left Atrium, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S639-S639, ISSN: 0009-7322

Conference paper

Al-Hussaini A, Baksi AJ, Hadjiloizou N, Davies JE, Manisty C, Kyriacou A, Foale RA, Tillin T, Parker KH, Francis DP, Mayet J, Hughes ADet al., 2009, HOW DOES WAVE INTENSITY CHANGE WITH HEART RATE? INSIGHT FROM CAROTID STUDY DURING PACING, 14th Annual Meeting of the European-Council-for-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 1171-1171, ISSN: 0194-911X

Conference paper

Manisty CH, Zambanini A, Parker KH, Davies JE, Francis DP, Mayet J, Thom SAM, Hughes ADet al., 2009, Differences in the Magnitude of Wave Reflection Account for Differential Effects of Amlodipine- Versus Atenolol-Based Regimens on Central Blood Pressure An Anglo-Scandinavian Cardiac Outcome Trial Substudy, HYPERTENSION, Vol: 54, Pages: 724-U73, ISSN: 0194-911X

Journal article

Wensel R, Jilek C, Doerr M, Francis DP, Stadler H, Lange T, Blumberg F, Opitz C, Pfeifer M, Ewert Ret al., 2009, Impaired cardiac autonomic control relates to disease severity in pulmonary hypertension, EUROPEAN RESPIRATORY JOURNAL, Vol: 34, Pages: 895-901, ISSN: 0903-1936

Journal article

Dimopoulos K, Giannakoulas G, Petraco R, Bendayan I, Diller GP, Swan L, Mullen MJ, Francis DP, Rubens M, Gatzoulis MAet al., 2009, The cardiothoracic ratio: a simple, strong and reproducible marker of disease severity and outcome in adults with congenital heart disease, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 800-800, ISSN: 0195-668X

Journal article

Dimopoulos K, Diller GP, Giannakoulas G, Petraco R, Karaoli E, Swan L, Mullen MJ, Piepoli MF, Francis DP, Gatzoulis MAet al., 2009, Anemia in adults with congenital heart disease relates to adverse outcome, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 800-800, ISSN: 0195-668X

Journal article

Raphael CE, Stain N, Wright I, Koa-Wing M, Kanagaratnam P, Francis DPet al., 2009, Implantable cardioverter defibrillators at the end of life: How much do patients want to know?, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 418-419, ISSN: 0195-668X

Journal article

Mebrate Y, Willson K, Manisty CH, Baruah R, Mayet J, Hughes AD, Parker KH, Francis DPet al., 2009, Dynamic CO<sub>2</sub> therapy in periodic breathing: a modeling study to determine optimal timing and dosage regimes, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 107, Pages: 696-706, ISSN: 8750-7587

Journal article

Davos CH, Moutafi AC, Alexandridi A, Petropoulou E, Varela E, Chamakou AC, Francis DP, Kilner PJ, Piepoli MF, Gatzoulis MAet al., 2009, Heart rate turbulence in adults with repaired tetralogy of Fallot, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 135, Pages: 308-314, ISSN: 0167-5273

Journal article

Davies JE, Parker KH, Francis DP, Hughes AD, Mayet Jet al., 2009, The authors' reply, Heart, Vol: 95, Pages: 937-938, ISSN: 1355-6037

Journal article

Davies J, Parker KH, Francis DP, Hughes AD, Mayet Jet al., 2009, What is the role of the aorta in directing coronary blood flow? Reply, HEART, Vol: 95, Pages: 937-938, ISSN: 1355-6037

Journal article

Lim PB, Stuber T, Koa-Wing M, Salukhe TV, Linton NWF, Kojodjojo P, Whinnett ZI, Francis DP, Davies DW, Peters NS, O'Neill MD, Kanagaratnam Pet al., 2009, ACTIVATION OF THE INTRINSIC CARDIAC AUTONOMIC NERVOUS SYSTEM INDUCES ECTOPY, INITIATING ATRIAL FIBRILLATION AND RESULTS IN A GRADIENT OF SHORTENING IN ATRIAL FIBRILLATION CYCLE LENGTHS IN THE PULMONARY VEINS AND ATRIA, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A1-A3, ISSN: 1355-6037

Conference paper

Giannoni A, Emdin M, Bramanti F, Iudice G, Francis DP, Barsotti A, Piepoli M, Passino Cet al., 2009, Combined Increased Chemosensitivity to Hypoxia and Hypercapnia as a Prognosticator in Heart Failure, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 53, Pages: 1975-1980, ISSN: 0735-1097

Journal article

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