Imperial College London

ProfessorDarrelFrancis

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3381d.francis Website

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

714 results found

Torii R, Wood NB, Hughes AD, Thom SA, Aguado-Sierra J, Davies JE, Francis DP, Parker KH, Xu XYet al., 2007, A computational study on the influence of catheter-delivered intravascular probes on blood flow in a coronary artery model, JOURNAL OF BIOMECHANICS, Vol: 40, Pages: 2501-2509, ISSN: 0021-9290

Journal article

Aguado-Sierra J, Parker KH, Davies JE, Francis D, Hughes AD, Mayet Jet al., 2006, Arterial pulse wave velocity in coronary arteries., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Pages: 867-870, ISSN: 1557-170X

Pulse wave velocity is related to arterial stiffness. Pulse wave velocity changes with age and disease and is a useful indicator of cardiovascular disease. Different methods are used for evaluating pulse wave velocity in systemic vessels, but none is applicable to coronary arteries. In this study we first compare values of wave speed (c) calculated from measurements of pressure (P) and velocity (U) using different analytical methods: PU-loop, beta stiffness parameter, characteristic impedance, foot-to-foot method, and the sum of squares (Sigma(2)), a novel way of calculating the wave speed (calculated from the square root of the sum of the ratio of the dP(2) and dU(2) over a complete cardiac cycle). Results from human measurements using Doppler ultrasound on carotid arteries show good correlation between the PU-loop method, beta stiffness parameter and Sigma(2). Characteristic impedance calculations show the greatest variation of all methods. The Sigma(2) method was further assessed in vitro for use in coronary vessels. Pressure and velocity measurements were obtained from human coronary arteries following angiographic studies. The measurements were made invasively by co-locating two wires with pressure and velocity transducers. Pressure and velocity data in the left anterior descending, circumflex, left main stem and right coronary arteries were acquired simultaneously along with the ECG signal. Wave speed was calculated using Sigma(2). Wave intensity analysis was used to determine forward and backward traveling waves at different times in different locations, for which wave speed, approximate distance and timings between waves need to be known.

Journal article

Manisty CH, Willson K, Davies JE, Whinnett ZI, Oldfield WLG, Hughes A, Mayet J, Francis DPet al., 2006, Can cardiac pacemakers directly control ventilation?, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II49-II49, ISSN: 0040-6376

Conference paper

Manisty CH, Willson K, Wensel R, Whinnett ZI, Davies JE, Oldfield WLG, Mayet J, Francis DPet al., 2006, Development of respiratory control instability in heart failure: a novel approach to dissect the pathophysiological mechanisms, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 577, Pages: 387-401, ISSN: 0022-3751

Journal article

Whinnett ZI, Davies JER, Willson K, Manisty CH, Chow AW, Foale RA, Davies DW, Hughes AD, Mayet J, Francis DPet al., 2006, Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: Analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay, HEART, Vol: 92, Pages: 1628-1634, ISSN: 1355-6037

Journal article

Davies JC, Francis DP, Whinnett ZI, Hadjiloizou N, Manisty CH, Willson K, Foale RA, Malik IS, Hughes AD, Parker KH, Mayet Jet al., 2006, Coronary Microcirculation Suction Wave is Reduced in Left Ventricular Hypertrophy: A Novel Assessment Using Wave Intensity Analysis, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 368-369, ISSN: 0009-7322

Conference paper

Bathula R, Chaturvedi N, Hughes A, Coady E, Francis Det al., 2006, Ethnic differences in heart rate variability unexplained by conventional risk factors, 11th Annual Meeting of the European-Council- for Cardiovascular Reseach, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 781-781, ISSN: 0194-911X

Conference paper

Diller G-P, Uebing A, Willson K, Davies LC, Dimopoulos K, Thorne SA, Gatzoulis MA, Francis DPet al., 2006, Analytical identification of ideal pulmonary-systemic flow balance in patients with bidirectional cavopulmonary shunt and univentricular circulation - Oxygen delivery or tissue oxygenation?, CIRCULATION, Vol: 114, Pages: 1243-1250, ISSN: 0009-7322

Journal article

Diller G-P, Dimopoulos K, Okonko D, Uebing A, Broberg CS, Babu-Narayan S, Bayne S, Poole-Wilson PA, Sutton R, Francis DP, Gatzoulis MAet al., 2006, Heart rate response during exercise predicts survival in adults with congenital heart disease, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 48, Pages: 1250-1256, ISSN: 0735-1097

Journal article

Davies JE, Hadjiloizou N, Whinnett ZI, Francis DP, Manisty CH, Hughes AD, Parker KH, Mayet Jet al., 2006, Evidence to support the augmentation of coronary blood flow in systole, by wave reflection from the aorta, 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 512-512, ISSN: 0195-668X

Conference paper

Whinnett ZI, Davies JER, Briscoe KA, Willson K, Manisty CH, Hughes AD, Mayet J, Francis DPet al., 2006, Optimisation of the atrioventricular delay of cardiac resynchronisation determined during exercise can be predicted by a resting pacing model, 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 193-193, ISSN: 0195-668X

Conference paper

Piepoli MF, Kaczmarek A, Francis DP, Davies LC, Rauchhaus M, Jankowska EA, Anker SD, Capucci A, Banasiak W, Ponikowski Pet al., 2006, Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure, CIRCULATION, Vol: 114, Pages: 126-134, ISSN: 0009-7322

Journal article

Dimopoulos K, Okonko DO, Diller G-P, Broberg CS, Salukhe TV, Babu-Narayan SV, Li W, Uebing A, Bayne S, Wensel R, Piepoli MF, Poole-Wilson PA, Francis DP, Gatzoulis MAet al., 2006, Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival, CIRCULATION, Vol: 113, Pages: 2796-2802, ISSN: 0009-7322

Journal article

Piepoli MF, Fattirolli F, Chieffo C, Griffo R, Pirelli S, Temporelli PL, Tramarin R, Urbinati S, Vigorito C, Vona M, Bjornstad H, Adamopoulos S, Dugmore L, Fioretti P, Gaita D, Mendes M, Bjarnason-Wehrens B, Helleman I, McGee H, Perk J, Corra U, Agostoni PG, Belardinelli R, Cohen-Solal A, Hambrecht R, Vanhees L, Coats AJS, Francis DP, Giannuzzi P, Guazzi M, Metra M, Mezzani A, Ponikowski P, Saner Het al., 2006, Statement on cardiopulmonary exercise testing in chronic heart failure due to left ventricular dysfunction: Recommendations for performance and interpretation Part II: How to perform cardiopulmonary exercise testing in chronic heart failure, European Journal of Preventive Cardiology, Vol: 13, Pages: 300-311, ISSN: 2047-4873

Basic and practical information related to equipment, methodology, exercise protocols, conduct of the test and quality control issues for cardiopulmonary exercise testing (CPET) will be addressed in this II part of the statement. CPET users have the responsibility for assuring that measurements remain accurate. CPT, especially when it features breath-by-breath gas exchange analysis, requires meticulous attention to calibration procedures to assure accurate and reproducible measurements. Skills and knowledge of personnel for supervision and test interpretation, as well as patient preparation and information are key features for a correct CPET conduction: all these issues will be faced. Finally, after the test, the investigator needs to format the results in a manner that optimises the ability to discriminate essential response features; that is, to establish ‘interpretive clusters— of the variables of interest. An example of a cardiopulmonary summary exercise test data report will be provided, defining the most important information that should be incorporated in a final report. © 2004, European Society of Cardiology. All rights reserved.

Journal article

Salukhe TV, Francis DP, Morgan M, Clague JR, Sutton R, Poole-Wilson P, Henein MYet al., 2006, Mechanism of cardiac output gain from cardiac resynchronization therapy in patients with coronary artery disease or idiopathic dilated cardiomyopathy, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 97, Pages: 1358-1364, ISSN: 0002-9149

Journal article

Whinnett ZI, Davies JER, Willson K, Chow AW, Foale RA, Davies DW, Hughes AD, Francis DP, Mayet Jet al., 2006, Determination of optimal atrioventricular delay for cardiac resynchronization therapy using acute non-invasive blood pressure, EUROPACE, Vol: 8, Pages: 358-366, ISSN: 1099-5129

Journal article

Davies J, Whinnett Z, Francis D, Manisty C, Willson K, Foale R, Malik I, Hughes A, Parker K, Mayet Jet al., 2006, Coronary blood flow is not augmented by aortic wave reflection: An invasive assessment using wave intensity analysis, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A35-A35, ISSN: 1355-6037

Conference paper

Whinnett Z, Davies J, Willson K, Manisty C, Chow A, Foale R, Davies D, Hughes A, Mayet J, Francis Det al., 2006, Changes in atrioventricular delay of cardiac resynchronisation therapy have a significantly larger haemodynamic effect compared with altering interventricular delay, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A114-A115, ISSN: 1355-6037

Conference paper

Whinnett Z, Davies J, Briscoe C, Willson K, Foale R, Davies D, Hughes A, Mayet J, Francis Det al., 2006, By pacing at increased rates at rest it is possible to predict the haemodynamic optimal atrioventricular delay of biventricular pacing determined during exercise, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A113-A114, ISSN: 1355-6037

Conference paper

Davies J, Whinnett Z, Francis D, Manisty C, Willson K, Foale R, Malik I, Hughes A, Parker K, Mayet Jet al., 2006, Evidence of a dominant backward-propagating "suction" wave, responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A2-A3, ISSN: 1355-6037

Conference paper

Manisty C, Davies J, Willson K, Whinnett Z, Hughes A, Mayet J, Francis Det al., 2006, Harnessing physiological cardiorespiratory interaction to modulate ventilation by dynamic changes in cardiac output, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A39-A40, ISSN: 1355-6037

Conference paper

Sharp A, Thom S, Francis D, Hughes A, Stanton A, Zombanini A, O'Brien E, Lyons S, Lang C, Byrd S, Poulter N, Sever P, Mayet Jet al., 2006, The ability of tissue Doppler echocardiography to predict future cardiovascular events in a hypertensive population: An ASCOT substudy, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: BMJ PUBLISHING GROUP, Pages: A34-A35, ISSN: 1355-6037

Conference paper

Davies JE, Whinnett ZI, Francis DP, Manisty CH, Aguado-Sierra J, Willson K, Foale RA, Malik IS, Hughes AD, Parker KH, Mayet Jet al., 2006, Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy, CIRCULATION, Vol: 113, Pages: 1768-1778, ISSN: 0009-7322

Journal article

Francis DP, 2006, Measurement of arterial wave speed

Patent

Rao A, Georgiadou P, Francis DP, Johnson A, Kremastinos DT, Simonds AK, Coats AJS, Cowley A, Morrell MJet al., 2006, Sleep-disordered breathing in a general heart failure population: relationships to neurohumoral activation and subjective symptoms, JOURNAL OF SLEEP RESEARCH, Vol: 15, Pages: 81-88, ISSN: 0962-1105

Journal article

Davies LC, Wensel R, Georgiadou P, Cicoira M, Coats AJS, Piepoli MF, Francis DPet al., 2006, Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope, EUROPEAN HEART JOURNAL, Vol: 27, Pages: 684-690, ISSN: 0195-668X

Journal article

Whinnett ZI, Davies JER, Willson K, Manisty CH, Chow AW, Foale RA, Davies DW, Hughes AD, Mayet J, Francis DPet al., 2006, The haemodynamic response to changes in atrioventricular and interventricular delay of cardiac resynchronization therapy closely fits a parabola, which may allow more efficient optimization, 55th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: 22A-22A, ISSN: 0735-1097

Conference paper

Piepoli MF, Corra U, Agostoni P, Belardinelli R, Giannuzzi P, Guazzi M, Metra M, Mezzani A, Cohen-Solal A, Hambrecht R, Vanhees L, Bjornstad H, Coats AJS, Francis DP, Ponikowski P, Saner Het al., 2006, Statement on cardiopulmonary exercise testing in chronic heart failure due to left ventricular dysfunction. Recommendations for performance and interpretation, European Journal of Preventive Cardiology, Vol: 13, Pages: 10-12, ISSN: 2047-4873

Journal article

Davies JE, Whinnett ZI, Francis DP, Willson K, Foale RA, Malik IS, Hughes AD, Parker KH, Mayet Jet al., 2006, Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 290, Pages: H878-H885, ISSN: 0363-6135

Journal article

Francis DP, 2006, Optimization of pacemakers for exercise

Patent

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