Imperial College London

ProfessorDarrelFrancis

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3381d.francis Website

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

712 results found

Francis D, 2006, The 2005 Scientific Sessions of the American Heart Association (AHA)., Heart Fail Monit, Vol: 5, Pages: 34-36, ISSN: 1470-8590

Journal article

Schmidt H, Mueller-Werdan U, Hoffmann T, Francis DP, Piepoli MF, Rauchhaus M, Prondzinsky R, Loppnow H, Buerke M, Hoyer D, Werdan Ket al., 2006, Attenuated autonomic function in multiple organ dysfunction syndrome across three age groups, BIOMEDIZINISCHE TECHNIK, Vol: 51, Pages: 264-267, ISSN: 0013-5585

Journal article

Aguado-Sierra J, Parker KH, Davies JE, Francis D, Hughes AD, Mayet Jet al., 2006, Arterial pulse wave velocity in coronary arteries., Conf Proc IEEE Eng Med Biol Soc, Vol: 2006, Pages: 867-870, ISSN: 1557-170X

Pulse wave velocity is related to arterial stiffness. Pulse wave velocity changes with age and disease and is a useful indicator of cardiovascular disease. Different methods are used for evaluating pulse wave velocity in systemic vessels, but none is applicable to coronary arteries. In this study we first compare values of wave speed (c) calculated from measurements of pressure (P) and velocity (U) using different analytical methods: PU-loop, beta stiffness parameter, characteristic impedance, foot-to-foot method, and the sum of squares (Sigma(2)), a novel way of calculating the wave speed (calculated from the square root of the sum of the ratio of the dP(2) and dU(2) over a complete cardiac cycle). Results from human measurements using Doppler ultrasound on carotid arteries show good correlation between the PU-loop method, beta stiffness parameter and Sigma(2). Characteristic impedance calculations show the greatest variation of all methods. The Sigma(2) method was further assessed in vitro for use in coronary vessels. Pressure and velocity measurements were obtained from human coronary arteries following angiographic studies. The measurements were made invasively by co-locating two wires with pressure and velocity transducers. Pressure and velocity data in the left anterior descending, circumflex, left main stem and right coronary arteries were acquired simultaneously along with the ECG signal. Wave speed was calculated using Sigma(2). Wave intensity analysis was used to determine forward and backward traveling waves at different times in different locations, for which wave speed, approximate distance and timings between waves need to be known.

Journal article

Wensel R, Francis DP, Georgiadou P, Scott A, Genth-Zotz S, Anker SD, Coats AJS, Piepoli MFet al., 2005, Exercise hyperventilation in chronic heart failure is not caused by systemic lactic acidosis, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 7, Pages: 1105-1111, ISSN: 1388-9842

Journal article

Piepoli MF, Kaczmarek A, Francis DP, Rauchhaus M, Banasiak W, Capucci A, Anker S, Ponikowski PPet al., 2005, Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure, 27th Congress of the European-Society-of-Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 186-187, ISSN: 0195-668X

Conference paper

Schmidt H, Mueller-Werdan U, Hoffmann T, Francis DP, Piepoli MF, Rauchhaus M, Prondzinsky R, Loppnow H, Buerke M, Hoyer D, Werdan Ket al., 2005, Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups, CRITICAL CARE MEDICINE, Vol: 33, Pages: 1994-2002, ISSN: 0090-3493

Journal article

Piepoli MF, Francis DP, 2005, ExTraMATCH: Exercise training meta analysis of trails in chronic heart failure patients: effect of concomitant drug therapy, 27th Congress of the European-Society-of-Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 629-630, ISSN: 0195-668X

Conference paper

Salukhe TV, Francis DP, Morgan M, Clague JR, Sutton R, Poole-Wilson P, Henein MYet al., 2005, Reduction in total isovolumic time under pharmacological stress: a final common pathway for cardiac output gain from cardiac resynchronisation therapy, 27th Congress of the European-Society-of-Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 54-54, ISSN: 0195-668X

Conference paper

Piepoli F, Kaczmarek A, Francis DP, Dimopoulos K, Davies LC, Capucci A, Banasiak W, Ponikowski PPet al., 2005, Systemic activation of skeletal muscle ergoreceptors is associated with the progression of the syndrome of chronic heart failure, 27th Congress of the European-Society-of-Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 635-635, ISSN: 0195-668X

Conference paper

Salukhe TV, Francis DP, 2005, Meta analysis does not show that cardiac resynchronisation reduces all cause mortality. A reply, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 103, Pages: 232-233, ISSN: 0167-5273

Journal article

Ghosh J, Freemantle N, Cleland J, 2005, Meta-analysis does not show that cardiac resynchronisation reduces all-cause mortality, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 103, Pages: 230-231, ISSN: 0167-5273

Journal article

Diller GP, Dimopoulos K, Okonko D, Li W, Babu-Narayan SV, Broberg CS, Johansson B, Bouzas B, Mullen MJ, Poole-Wilson PA, Francis DP, Gatzoulis MAet al., 2005, Exercise intolerance in adult congenital heart disease - Comparative severity, correlates, and prognostic implication, CIRCULATION, Vol: 112, Pages: 828-835, ISSN: 0009-7322

Journal article

Whinnett ZI, Davies JER, Lane RE, Francis DP, Mayet Jet al., 2005, Echocardiographic methods for selecting patients suitable for biventricular pacing therapy., Minerva Cardioangiol, Vol: 53, Pages: 211-220, ISSN: 0026-4725

The large outcome studies of biventricular pacing to date have selected patients using electrocardiogram criteria (prolonged QRS and left bundle branch block morphology). However, 20-30% of patients do not appear to respond clinically, and as a result there has been much interest in developing more specific methods of detecting mechanical dyssynchrony. A number of different echocardiographic techniques have been developed which appear to offer greater sensitivity and specificity than ECG in selecting these patients. This paper reviews the most promising of the echocardiographic techniques and gives guidance for the clinical use of echocardiography in selecting patients for biventricular pacing.

Journal article

Arshad W, Duncan AM, Francis DP, O'Sullivan CA, Gibson DG, Henein MYet al., 2005, Opposite effects of coronary artery disease and hypertrophic cardiomyopathy on left ventricular long axis function during dobutamine stress, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 101, Pages: 123-128, ISSN: 0167-5273

Journal article

Mathony U, Schmidt H, Gröger C, Francis DP, Konzag I, Müller-Werdan U, Werdan K, Syska Jet al., 2005, Optimal maximum tracking rate of dual-chamber pacemakers required by children and young adults for a maximal cardiorespiratory performance, PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 28, Pages: 378-383, ISSN: 0147-8389

Journal article

Davies J, Whinnett Z, Francis D, Willson K, Foale R, Malik I, Thom S, Hughes A, Parker K, Mayet Jet al., 2005, Effect of nitrate administration on wave speed propagation in the human coronary artery, Annual Conference of G-MEX/MICC, Publisher: B M J PUBLISHING GROUP, Pages: A66-A67, ISSN: 1355-6037

Conference paper

Salukhe TV, Francis DP, Clague JR, Sutton R, Poole-Wilson P, Henein MYet al., 2005, Chronic heart failure patients with restrictive LV filling pattern have significantly less benefit from cardiac resynchronization therapy than patients with late LV filling pattern, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 100, Pages: 5-12, ISSN: 0167-5273

Journal article

Schmidt H, Francis DP, Rauchhaus M, Werdan K, Piepoli MFet al., 2005, Chemo- and ergoreflexes in health, disease and ageing, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 98, Pages: 369-378, ISSN: 0167-5273

Journal article

Whinnett ZI, Davies JER, Willson K, Chow AW, Foale RA, Davies DW, Hughes AD, Francis DP, Mayet Jet al., 2005, Continuous non-invasive hemodynamic monitoring to optimize atrioventricular delay in cardiac resychronization therapy, 54th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: 99A-99A, ISSN: 0735-1097

Conference paper

Davies JE, Whinnett ZI, Francis DP, Willson K, Foale RA, Malik L, Hughes AD, Parker KH, Mayet Jet al., 2005, Effect of left ventricular hypertrophy on human coronary artery haemodynamics., 54th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: 431A-431A, ISSN: 0735-1097

Conference paper

Francis DP, 2005, Optimization of pacemakers using non-invasive haemodynamics

Patent

Chen QM, Li W, O'Sullivan C, Francis DP, Gibson D, Henein MYet al., 2004, Clinical in vivo calibration of pulse wave tissue Doppler velocities the assessment of ventricular wall motion. A comparison study with M-mode echocardiography, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 97, Pages: 289-295, ISSN: 0167-5273

Journal article

Arshad W, Duncan AM, Francis DP, O'Sullivan CA, Gibson DG, Henein MYet al., 2004, Systole-diastole mismatch in hypertrophic cardiomyopathy is caused by stress induced left ventricular outflow tract obstruction, AMERICAN HEART JOURNAL, Vol: 148, Pages: 903-909, ISSN: 0002-8703

Journal article

Scott AC, Wensel R, Davos CH, Georgiadou P, Davies LC, Coats AJS, Francis DP, Piepoli MFet al., 2004, Putative contribution of prostaglandin and bradykinin to muscle reflex hyperactivity in patients on ace-inhibitor therapy for chronic heart failure, EUROPEAN HEART JOURNAL, Vol: 25, Pages: 1806-1813, ISSN: 0195-668X

Journal article

Cicoira M, Davos CH, Francis DP, Doehner W, Zanolla L, Franceschini L, Piepoli MF, Coats AJS, Zardini P, Poole-Wilson PA, Anker SDet al., 2004, Prediction of mortality in chronic, heart failure from peak oxygen consumption adjusted for either body weight or lean tissue, JOURNAL OF CARDIAC FAILURE, Vol: 10, Pages: 421-426, ISSN: 1071-9164

Journal article

Li W, Hornung TS, Francis DP, O'Sullivan C, Duncan A, Gatzoulis M, Henein Met al., 2004, Relation of biventricular function quantified by stress echocardiography to cardiopulmonary exercise capacity in adults with mustard (atrial switch) procedure for transposition of the great arteries, CIRCULATION, Vol: 110, Pages: 1380-1386, ISSN: 0009-7322

Journal article

Piepoli MF, Davos C, Francis DP, Massie Bet al., 2004, Review: Exercise training delays death and hospital admission in chronic heart failure, Evidence-Based Medicine, Vol: 9, ISSN: 1356-5524

Journal article

Georgiadou P, Babu-Narayan SV, Francis DP, Kremastinos DT, Gatzoulis MAet al., 2004, Periodic breathing as a feature of right heart failure in congenital heart disease, HEART, Vol: 90, Pages: 1075-1076, ISSN: 1355-6037

Journal article

Piepoli MF, Scott A, Wensel R, Francis DP, Davos CH, Georgiadou P, Davies LC, Coats AJSet al., 2004, Contribution of prostaglandins and bradykinin to muscle reflex hyperactivity in patients with chronic heart failure, ESC Congress 2004, Publisher: W B SAUNDERS CO LTD, Pages: 283-283, ISSN: 0195-668X

Conference paper

Sharma R, Francis DP, Pitt B, Poole-Wilson PA, Coats AJS, Anker SDet al., 2004, Haemoglobin predicts survival in patients with chronic heart failure: a substudy of the ELITE II trial, EUROPEAN HEART JOURNAL, Vol: 25, Pages: 1021-1028, ISSN: 0195-668X

Journal article

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