Imperial College London
Alternate

ProfessorDarrelFrancis

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 3381d.francis Website

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Thompson:2021:10.1002/prp2.710,
author = {Thompson, D and Al-Lamee, R and Foley, M and Dehbi, HM and Thom, S and Davies, JE and Francis, DP and Patel, P and Gupta, P and ORBITA, Investigators},
doi = {10.1002/prp2.710},
journal = {Pharmacology Research and Perspectives},
pages = {e00710--e00710},
title = {Achieving optimal adherence to medical therapy by telehealth: Findings from the ORBITA medication adherence sub-study},
url = {http://dx.doi.org/10.1002/prp2.710},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: The ORBITA trial of percutaneous coronary intervention (PCI) versus a placebo procedure for patients with stable angina was conducted across six sites in the United Kingdom via home monitoring and telephone consultations. Patients underwent detailed assessment of medication adherence which allowed us to measure the efficacy of the implementation of the optimization protocol and interpretation of the main trial endpoints. METHODS: Prescribing data were collected throughout the trial. Self-reported adherence was assessed, and urine samples collected at pre-randomization and at follow-up for direct assessment of adherence using high-performance liquid chromatography with tandem mass spectrometry (HPLC MS/MS). RESULTS: Self-reported adherence was >96% for all drugs in both treatment groups at both stages. The percentage of samples in which drug was detected at pre-randomization and at follow-up in the PCI versus placebo groups respectively was: clopidogrel, 96% versus 90% and 98% versus 94%; atorvastatin, 95% versus 92% and 92% versus 91%; perindopril, 95% versus 97% and 85% versus 100%; bisoprolol, 98% versus 99% and 96% versus 97%; amlodipine, 99% versus 99% and 94% versus 96%; nicorandil, 98% versus 96% and 94% versus 92%; ivabradine, 100% versus 100% and 100% versus 100%; and ranolazine, 100% versus 100% and 100% versus 100%. CONCLUSIONS: Adherence levels were high throughout the study when quantified by self-reporting methods and similarly high proportions of drug were detected by urinary assay. The results indicate successful implementation of the optimization protocol delivered by telephone, an approach that could serve as a model for treatment of chronic conditions, particularly as consultations are increasingly conducted online.
AU  - Thompson,D
AU  - Al-Lamee,R
AU  - Foley,M
AU  - Dehbi,HM
AU  - Thom,S
AU  - Davies,JE
AU  - Francis,DP
AU  - Patel,P
AU  - Gupta,P
AU  - ORBITA,Investigators
DO  - 10.1002/prp2.710
EP  - 00710
PY  - 2021///
SN  - 2052-1707
SP  - 00710
TI  - Achieving optimal adherence to medical therapy by telehealth: Findings from the ORBITA medication adherence sub-study
T2  - Pharmacology Research and Perspectives
UR  - http://dx.doi.org/10.1002/prp2.710
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33570248
UR  - http://hdl.handle.net/10044/1/86234
VL  - 9
ER  -
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