Imperial College London


Faculty of EngineeringDepartment of Electrical and Electronic Engineering

Research Assistant







Electrical EngineeringSouth Kensington Campus






BibTex format

author = {Ramezani, R and Liu, Y and Dehkhoda, F and Soltan, A and Haci, D and Zhao, H and Hazra, A and Cunningham, M and Firfilionis, D and Jackson, A and Constandinou, TG and Degenaar, P},
doi = {10.1109/TBCAS.2018.2818818},
journal = {IEEE Transactions on Biomedical Circuits and Systems},
pages = {576--588},
title = {On-probe neural interface ASIC for combined electrical recording and optogenetic stimulation},
url = {},
volume = {12},
year = {2018}

RIS format (EndNote, RefMan)

AB - Neuromodulation technologies are progressing from pacemaking and sensory operations to full closed-loop control. In particular, optogenetics—the genetic modification of light sensitivity into neural tissue allows for simultaneous optical stimulation and electronic recording. This paper presents a neural interface application-specified integrated circuit (ASIC) for intelligent optoelectronic probes. The architecture is designed to enable simultaneous optical neural stimulation and electronic recording. It provides four low noise (2.08 μVrms) recording channels optimized for recording local field potentials (LFPs) (0.1–300 Hz bandwidth, ± 5 mV range, sampled 10-bit@4 kHz), which are more stable for chronic applications. For stimulation, it provides six independently addressable optical driver circuits, which can provide both intensity (8-bit resolution across a 1.1 mA range) and pulse-width modulation for high-radiance light emitting diodes (LEDs). The system includes a fully digital interface using a serial peripheral interface (SPI) protocol to allow for use with embedded controllers. The SPI interface is embedded within a finite state machine (FSM), which implements a command interpreter that can send out LFP data whilst receiving instructions to control LED emission. The circuit has been implemented in a commercially available 0.35 μm CMOS technology occupying a 1.95 mm × 1.10 mm footprint for mounting onto the head of a silicon probe. Measured results are given for a variety of bench-top, in vitro and in vivo experiments, quantifying system performance and also demonstrating concurrent recording and stimulation within relevant experimental models.
AU - Ramezani,R
AU - Liu,Y
AU - Dehkhoda,F
AU - Soltan,A
AU - Haci,D
AU - Zhao,H
AU - Hazra,A
AU - Cunningham,M
AU - Firfilionis,D
AU - Jackson,A
AU - Constandinou,TG
AU - Degenaar,P
DO - 10.1109/TBCAS.2018.2818818
EP - 588
PY - 2018///
SN - 1932-4545
SP - 576
TI - On-probe neural interface ASIC for combined electrical recording and optogenetic stimulation
T2 - IEEE Transactions on Biomedical Circuits and Systems
UR -
UR -
UR -
VL - 12
ER -