Imperial College London

ProfessorDavidHolden

Faculty of MedicineDepartment of Medicine

Professor
 
 
 
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Contact

 

+44 (0)20 7594 3073d.holden

 
 
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Location

 

221Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

118 results found

McGourty K, Thurston TL, Matthews SA, Pinaud L, Mota LJ, Holden DWet al., 2012, Salmonella Inhibits Retrograde Trafficking of Mannose-6-Phosphate Receptors and Lysosome Function, SCIENCE, Vol: 338, Pages: 963-967, ISSN: 0036-8075

JOURNAL ARTICLE

Mesquita FS, Thomas M, Sachse M, Santos AJM, Figueira R, Holden DWet al., 2012, The Salmonella Deubiquitinase SseL Inhibits Selective Autophagy of Cytosolic Aggregates, PLOS PATHOGENS, Vol: 8, ISSN: 1553-7374

JOURNAL ARTICLE

Odendall C, Rolhion N, Foerster A, Poh J, Lamont DJ, Liu M, Freemont PS, Catling AD, Holden DWet al., 2012, The Salmonella Kinase SteC Targets the MAP Kinase MEK to Regulate the Host Actin Cytoskeleton, CELL HOST & MICROBE, Vol: 12, Pages: 657-668, ISSN: 1931-3128

JOURNAL ARTICLE

Thomas M, Mesquita FS, Holden DW, 2012, The DUB-ious lack of ALIS in Salmonella infection A Salmonella deubiquitinase regulates the autophagy of protein aggregates, AUTOPHAGY, Vol: 8, Pages: 1824-1826, ISSN: 1554-8627

JOURNAL ARTICLE

Thompson JA, Liu M, Helainet S, Holden DWet al., 2011, Contribution of the PhoP/Q regulon to survival and replication of Salmonella enterica serovar Typhimurium in macrophages, MICROBIOLOGY-SGM, Vol: 157, Pages: 2084-2093, ISSN: 1350-0872

JOURNAL ARTICLE

Yu X-J, Liu M, Matthews S, Holden DWet al., 2011, Tandem Translation Generates a Chaperone for the Salmonella Type III Secretion System Protein SsaQ, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 286, Pages: 36098-36107, ISSN: 0021-9258

JOURNAL ARTICLE

Dumont A, Boucrot E, Drevensek S, Daire V, Gorvel J-P, Poues C, Holden DW, Meresse Set al., 2010, SKIP, the Host Target of the Salmonella Virulence Factor SifA, Promotes Kinesin-1-Dependent Vacuolar Membrane Exchanges, TRAFFIC, Vol: 11, Pages: 899-911, ISSN: 1398-9219

JOURNAL ARTICLE

Groves E, Rittinger K, Amstutz M, Berry S, Holden DW, Cornelis GR, Caron Eet al., 2010, Sequestering of Rac by the Yersinia Effector YopO Blocks Fc gamma Receptor-mediated Phagocytosis, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 4087-4098, ISSN: 0021-9258

JOURNAL ARTICLE

Helaine S, Thompson JA, Watson KG, Liu M, Boyle C, Holden DWet al., 2010, Dynamics of intracellular bacterial replication at the single cell level, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 3746-3751, ISSN: 0027-8424

JOURNAL ARTICLE

Watson KG, Holden DW, 2010, Dynamics of growth and dissemination of Salmonella in vivo, CELLULAR MICROBIOLOGY, Vol: 12, Pages: 1389-1397, ISSN: 1462-5814

JOURNAL ARTICLE

Yu X-J, McGourty K, Liu M, Unsworth KE, Holden DWet al., 2010, pH Sensing by Intracellular Salmonella Induces Effector Translocation, SCIENCE, Vol: 328, Pages: 1040-1043, ISSN: 0036-8075

JOURNAL ARTICLE

Lapaque N, Hutchinson JL, Jones DC, Meresse S, Holden DW, Trowsdale J, Kelly APet al., 2009, Salmonella regulates polyubiquitination and surface expression of MHC class II antigens, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 14052-14057, ISSN: 0027-8424

JOURNAL ARTICLE

Mota LJ, Ramsden AE, Liu M, Castle JD, Holden DWet al., 2009, SCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking, CELLULAR MICROBIOLOGY, Vol: 11, Pages: 1236-1253, ISSN: 1462-5814

JOURNAL ARTICLE

Thomas M, Holden DW, 2009, Ubiquitination-A Bacterial Effector's Ticket to Ride, CELL HOST & MICROBE, Vol: 5, Pages: 309-311, ISSN: 1931-3128

JOURNAL ARTICLE

Lossi NS, Rolhion N, Magee AI, Boyle C, Holden DWet al., 2008, The Salmonella SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid: cholesterol acyltransferase activity, MICROBIOLOGY-SGM, Vol: 154, Pages: 2680-2688, ISSN: 1350-0872

JOURNAL ARTICLE

Mazurkiewicz P, Thomas J, Thompson JA, Liu M, Arbibe L, Sansonetti P, Holden DWet al., 2008, SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases, MOLECULAR MICROBIOLOGY, Vol: 67, Pages: 1371-1383, ISSN: 0950-382X

JOURNAL ARTICLE

Poh J, Odendall C, Spanos A, Boyle C, Liu M, Freemont P, Holden DWet al., 2008, SteC is a Salmonella kinase required for SPI-2-dependent F-actin remodelling, CELLULAR MICROBIOLOGY, Vol: 10, Pages: 20-30, ISSN: 1462-5814

JOURNAL ARTICLE

Nelson AL, Ries J, Bagnoli F, Dahlberg S, Falker S, Rounioja S, Tschop J, Morfeldt E, Ferlenghi I, Hilleringmann M, Holden DW, Rappuoli R, Normark S, Barocchi MA, Henriques-Normark Bet al., 2007, RrgA is a pilus-associated adhesin in Streptococcus pneumoniae, MOLECULAR MICROBIOLOGY, Vol: 66, Pages: 329-340, ISSN: 0950-382X

JOURNAL ARTICLE

Ramsden AE, Holden DW, Mota LJ, 2007, Membrane dynamics and spatial distribution of Salmonella-containing vacuoles, TRENDS IN MICROBIOLOGY, Vol: 15, Pages: 516-524, ISSN: 0966-842X

JOURNAL ARTICLE

Ramsden AE, Mota LJ, Muenter S, Shorte SL, Holden DWet al., 2007, The SPI-2 type III secretion system restricts motility of Salmonella-containing vacuoles, CELLULAR MICROBIOLOGY, Vol: 9, Pages: 2517-2529, ISSN: 1462-5814

JOURNAL ARTICLE

Rytkoenen A, Holden DW, 2007, Bacterial interference of ubiquitination and deubiquitination, CELL HOST & MICROBE, Vol: 1, Pages: 13-22, ISSN: 1931-3128

JOURNAL ARTICLE

Rytkonen A, Poh J, Garmendia J, Boyle C, Thompson A, Liu M, Freemont P, Hinton JCD, Holden DWet al., 2007, SseL, a Salmonella deubiquitinase required for macrophage killing and virulence, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 3502-3507, ISSN: 0027-8424

JOURNAL ARTICLE

Unsworth KE, Mazurkiewicz P, Senf F, Zettl M, McNiven M, Way M, Holden DWet al., 2007, Dynamin is required for F-actin assembly and pedestal formation by enteropathogenic Escherichia coli (EPEC), CELLULAR MICROBIOLOGY, Vol: 9, Pages: 438-449, ISSN: 1462-5814

JOURNAL ARTICLE

Barocchi MA, Rie J, Zogaj X, Hemsley C, Albiger B, Kanth A, Dahlberg S, Fernebro J, Moschioni M, Masignani V, Hultenby K, Taddei AR, Beiter K, Wartha F, von Euler A, Covacci A, Holden DW, Normark S, Rappuoli R, Henriques-Normark Bet al., 2006, A pneumococcal pilus influences virulence and host inflammatory responses, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 2857-2862, ISSN: 0027-8424

JOURNAL ARTICLE

Deiwick J, Salcedo SP, Boucrot E, Gilliland SM, Henry T, Petermann N, Waterman SR, Gorvel J-P, Holden DW, Meresse Set al., 2006, The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche, INFECTION AND IMMUNITY, Vol: 74, Pages: 6965-6972, ISSN: 0019-9567

JOURNAL ARTICLE

Mazurkiewicz P, Tang CM, Boone C, Holden DWet al., 2006, Signature-tagged mutagenesis: barcoding mutants for genome-wide screens, NATURE REVIEWS GENETICS, Vol: 7, Pages: 929-939, ISSN: 1471-0056

JOURNAL ARTICLE

Ygberg SE, Clements MO, Rytkonen A, Thompson A, Holden DW, Hinton JCD, Rhen Met al., 2006, Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica, INFECTION AND IMMUNITY, Vol: 74, Pages: 1243-1254, ISSN: 0019-9567

JOURNAL ARTICLE

Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang ZY, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan Cet al., 2005, A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP, MOLECULAR MICROBIOLOGY, Vol: 56, Pages: 1234-1245, ISSN: 0950-382X

JOURNAL ARTICLE

Linehan SA, Rytkonen A, Yu XJ, Liu M, Holden DWet al., 2005, SlyA regulates function of Salmonella pathogenicity island 2 (SPI-2) and expression of SPI-2-associated genes, INFECTION AND IMMUNITY, Vol: 73, Pages: 4354-4362, ISSN: 0019-9567

JOURNAL ARTICLE

Mota LJ, Holden DW, 2005, FlAsHlights on bacterial virulence proteins, NATURE METHODS, Vol: 2, Pages: 898-899, ISSN: 1548-7091

JOURNAL ARTICLE

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