Imperial College London

ProfessorDavidHolden

Faculty of MedicineDepartment of Medicine

Professor
 
 
 
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Contact

 

+44 (0)20 7594 3073d.holden

 
 
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Location

 

221Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

118 results found

Salcedo SP, Holden DW, 2005, Bacterial interactions with the eukaryotic secretory pathway, CURRENT OPINION IN MICROBIOLOGY, Vol: 8, Pages: 92-98, ISSN: 1369-5274

JOURNAL ARTICLE

Yuste J, Botto M, Paton JC, Holden DW, Brown JSet al., 2005, Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 1813-1819, ISSN: 0022-1767

JOURNAL ARTICLE

, 2005, Anti-bacterial methods & materials, WO99/01473

PATENT

Batchelor M, Guignot J, Patel A, Cummings N, Cleary J, Knutton S, Holden DW, Connerton I, Frankel Get al., 2004, Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection, EMBO REPORTS, Vol: 5, Pages: 104-109, ISSN: 1469-221X

JOURNAL ARTICLE

Brown JS, Gilliland SM, Basavanna S, Holden DWet al., 2004, phgABC, a three-gene operon required for growth of Streptococcus pneumoniae in hy erosmotic medium and in vivo, INFECTION AND IMMUNITY, Vol: 72, Pages: 4579-4588, ISSN: 0019-9567

JOURNAL ARTICLE

Brown JS, Gilliland SM, Ruiz-Albert J, Holden DWet al., 2004, Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter (vol 70, pg 4389, 2004), INFECTION AND IMMUNITY, Vol: 72, Pages: 6754-6754, ISSN: 0019-9567

JOURNAL ARTICLE

Brown JS, Gilliland SM, Spratt BG, Holden DWet al., 2004, A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice, INFECTION AND IMMUNITY, Vol: 72, Pages: 1587-1593, ISSN: 0019-9567

JOURNAL ARTICLE

Brown JS, Ogunniyi AD, Woodrow MC, Holden DW, Paton JCet al., 2004, Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection (vol 69, pg 6702, 2004), INFECTION AND IMMUNITY, Vol: 72, Pages: 6755-6755, ISSN: 0019-9567

JOURNAL ARTICLE

Guignot J, Caron E, Beuzon C, Bucci C, Kagan J, Roy C, Holden DWet al., 2004, Microtubule motors control membrane dynamics of Salmonella-containing vacuoles, JOURNAL OF CELL SCIENCE, Vol: 117, Pages: 1033-1045, ISSN: 0021-9533

JOURNAL ARTICLE

Petrovska L, Aspinall RJ, Barber L, Clare S, Simmons CP, Stratford R, Khan SA, Lemoine NR, Frankel G, Holden DW, Dougan Get al., 2004, Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene, CELLULAR MICROBIOLOGY, Vol: 6, Pages: 1071-1084, ISSN: 1462-5814

JOURNAL ARTICLE

Unsworth KE, Way M, McNiven M, Machesky L, Holden DWet al., 2004, Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication, CELLULAR MICROBIOLOGY, Vol: 6, Pages: 1041-1055, ISSN: 1462-5814

JOURNAL ARTICLE

Yu XJ, Liu M, Holden DW, 2004, SsaM and SpiC interact and regulate secretion of Salmonella Pathogenicity Island 2 type III secretion system effectors and translocators, MOLECULAR MICROBIOLOGY, Vol: 54, Pages: 604-619, ISSN: 0950-382X

JOURNAL ARTICLE

Boucrot E, Beuzon CR, Holden DW, Gorvel JP, Meresse Set al., 2003, Salmonella typhimurium SifA effector protein requires its membrane-anchoring C-terminal hexapeptide for its biological function, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 14196-14202, ISSN: 0021-9258

JOURNAL ARTICLE

Garmendia J, Beuzon CR, Ruiz-Albert J, Holden DWet al., 2003, The roles of SsrA-SsrB and OmpR-EnvZ in the regulation of genes encoding the Salmonella typhimurium SPI-2 type III secretion system, MICROBIOLOGY-SGM, Vol: 149, Pages: 2385-2396, ISSN: 1350-0872

JOURNAL ARTICLE

Linehan SA, Holden DW, 2003, The interplay between Salmonella typhimurium and its macrophage host - what can it teach us about innate immunity?, IMMUNOLOGY LETTERS, Vol: 85, Pages: 183-192, ISSN: 0165-2478

JOURNAL ARTICLE

Mellado E, Dubreucq G, Mol P, Sarfati J, Paris S, Diaquin M, Holden DW, Rodriguez-Tudela JL, Latge JPet al., 2003, Cell wall biogenesis in a double chitin synthase mutant (chsG(-)/chsE(-)) of Aspergillus fumigatus, FUNGAL GENETICS AND BIOLOGY, Vol: 38, Pages: 98-109, ISSN: 1087-1845

JOURNAL ARTICLE

Ramos-Morales F, Prieto AI, Beuzon CR, Holden DW, Casadesus Jet al., 2003, Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence, JOURNAL OF BACTERIOLOGY, Vol: 185, Pages: 5328-5332, ISSN: 0021-9193

JOURNAL ARTICLE

Ruiz-Albert J, Mundy R, Yu XJ, Beuzon CR, Holden DWet al., 2003, SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2-encoded type III secretion system, MICROBIOLOGY-SGM, Vol: 149, Pages: 1103-1111, ISSN: 1350-0872

JOURNAL ARTICLE

Salcedo SP, Holden DW, 2003, SseG, a virulence protein that targets Salmonella to the Golgi network, EMBO JOURNAL, Vol: 22, Pages: 5003-5014, ISSN: 0261-4189

JOURNAL ARTICLE

Waterman SR, Holden DW, 2003, Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system, CELLULAR MICROBIOLOGY, Vol: 5, Pages: 501-511, ISSN: 1462-5814

JOURNAL ARTICLE

Beuzon CR, Salcedo SP, Holden DW, 2002, Growth and killing of a Salmonella enterica serovar Typhimurium sifA mutant strain in the cytosol of different host cell lines, MICROBIOLOGY-SGM, Vol: 148, Pages: 2705-2715, ISSN: 1350-0872

JOURNAL ARTICLE

Brown JS, Gilliland SM, Ruiz-Albert J, Holden DWet al., 2002, Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter, INFECTION AND IMMUNITY, Vol: 70, Pages: 4389-4398, ISSN: 0019-9567

JOURNAL ARTICLE

Brown JS, Holden DW, 2002, Iron acquisition by Gram-positive bacterial pathogens, MICROBES AND INFECTION, Vol: 4, Pages: 1149-1156, ISSN: 1286-4579

JOURNAL ARTICLE

Brown JS, Hussell T, Gilliland SM, Holden DW, Paton JC, Ehrenstein MR, Walport MJ, Botto Met al., 2002, The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 16969-16974, ISSN: 0027-8424

JOURNAL ARTICLE

Garvis S, Mei JM, Ruiz-Albert J, Holden DWet al., 2002, Staphylococcus aureus svrA: a gene required for virulence and expression of the agr locus, MICROBIOLOGY-SGM, Vol: 148, Pages: 3235-3243, ISSN: 1350-0872

JOURNAL ARTICLE

Hindle Z, Chatfield SN, Phillimore J, Bentley M, Johnson J, Cosgrove CA, Ghaem-Maghami M, Sexton A, Khan M, Brennan FR, Everest P, Wu T, Pickard D, Holden DW, Dougan G, Griffin GE, House D, Santangelo JD, Khan SA, Shea JE, Feldman RG, Lewis DJAet al., 2002, Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers, INFECTION AND IMMUNITY, Vol: 70, Pages: 3457-3467, ISSN: 0019-9567

JOURNAL ARTICLE

Holden DW, 2002, Trafficking of the Salmonella vacuole in macrophages, TRAFFIC, Vol: 3, Pages: 161-169, ISSN: 1398-9219

JOURNAL ARTICLE

Pawelek JM, Sodi S, Chakraborty AK, Platt JT, Miller S, Holden DW, Hensel M, Low KBet al., 2002, Salmonella pathogenicity island-2 and anticancer activity in mice, CANCER GENE THERAPY, Vol: 9, Pages: 813-818, ISSN: 0929-1903

JOURNAL ARTICLE

Ruiz-Albert J, Yu XJ, Beuzon CR, Blakey AN, Galyov EE, Holden DWet al., 2002, Complementary activities of SseJ and SifA regulate dynamics of the Salmonella typhimurium vacuolar membrane, MOLECULAR MICROBIOLOGY, Vol: 44, Pages: 645-661, ISSN: 0950-382X

JOURNAL ARTICLE

Yu XJ, Ruiz-Albert J, Unsworth KE, Garvis S, Liu M, Holden DWet al., 2002, SpiC is required for secretion of Salmonella Pathogenicity Island 2 type III secretion system proteins, CELLULAR MICROBIOLOGY, Vol: 4, Pages: 531-540, ISSN: 1462-5814

JOURNAL ARTICLE

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