Imperial College London

ProfessorDavidHolden

Faculty of MedicineDepartment of Medicine

Professor
 
 
 
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Contact

 

+44 (0)20 7594 3073d.holden

 
 
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Location

 

221Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

118 results found

, 2002, Identification of Genes

PATENT

Beuzon CR, Holden DW, 2001, Use of mixed infections with Salmonella strains to study virulence genes and their interactions in vivo, MICROBES AND INFECTION, Vol: 3, Pages: 1345-1352, ISSN: 1286-4579

JOURNAL ARTICLE

Beuzon CR, Unsworth KE, Holden DW, 2001, In vivo genetic analysis indicates that PhoP-PhoQ and the Salmonella pathogenicity island 2 type III secretion system contribute independently to Salmonella enterica serovar typhimurium virulence, INFECTION AND IMMUNITY, Vol: 69, Pages: 7254-7261, ISSN: 0019-9567

JOURNAL ARTICLE

Brown JS, Gilliland SM, Holden DW, 2001, A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence, MOLECULAR MICROBIOLOGY, Vol: 40, Pages: 572-585, ISSN: 0950-382X

JOURNAL ARTICLE

Brown JS, Ogunniyi AD, Gilliland SN, Woodrow MC, Holden DW, Paton JCet al., 2001, Immunisation with ABC transporter proteins protects against Streptococcus pneumoniae infection, THORAX, Vol: 56, Pages: 26-26, ISSN: 0040-6376

JOURNAL ARTICLE

Brown JS, Ogunniyi AD, Woodrow MC, Holden DW, Paton JCet al., 2001, Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection, INFECTION AND IMMUNITY, Vol: 69, Pages: 6702-6706, ISSN: 0019-9567

JOURNAL ARTICLE

Garvis SG, Beuzon CR, Holden DW, 2001, A role for the PhoP/Q regulon in inhibition of fusion between lysosomes and Salmonella-containing vacuoles in macrophages, CELLULAR MICROBIOLOGY, Vol: 3, Pages: 731-744, ISSN: 1462-5814

JOURNAL ARTICLE

Lau GW, Haataja S, Lonetto M, Kensit SE, Marra A, Bryant AP, McDevitt D, Morrison DA, Holden DWet al., 2001, A functional genomic analysis of type 3 Streptococcus pneumoniae virulence, MOLECULAR MICROBIOLOGY, Vol: 40, Pages: 555-571, ISSN: 0950-382X

JOURNAL ARTICLE

Meresse S, Unsworth KE, Habermann A, Griffiths G, Fang F, Martinez-Lorenzo MJ, Waterman SR, Gorvel JP, Holden DWet al., 2001, Remodelling of the actin cytoskeleton is essential for replication of intravacuolar Salmonella, CELLULAR MICROBIOLOGY, Vol: 3, Pages: 567-577, ISSN: 1462-5814

JOURNAL ARTICLE

Salcedo SP, Noursadeghi M, Cohen J, Holden DWet al., 2001, Intracellular replication of Salmonella typhimurium strains in specific subsets of splenic macrophages in vivo, CELLULAR MICROBIOLOGY, Vol: 3, Pages: 587-597, ISSN: 1462-5814

JOURNAL ARTICLE

Webb JL, Harvey MW, Holden DW, Evans TJet al., 2001, Macrophage nitric oxide synthase associates with cortical actin but is not recruited to phagosomes, INFECTION AND IMMUNITY, Vol: 69, Pages: 6391-6400, ISSN: 0019-9567

JOURNAL ARTICLE

Yu J, Bryant AP, Marra A, Lonetto MA, Ingraham KA, Chalker AF, Holmes DJ, Holden D, Rosenberg M, McDevitt Det al., 2001, Characterization of the Streptococcus pneumoniae NADH oxidase that is required for infection, MICROBIOLOGY-UK, Vol: 147, Pages: 431-438, ISSN: 1350-0872

JOURNAL ARTICLE

, 2001, Identification of Genes

PATENT

, 2001, Identification of Genes

PATENT

Beuzon CR, Meresse S, Unsworth KE, Ruiz-Albert J, Garvis S, Waterman SR, Ryder TA, Boucrot E, Holden DWet al., 2000, Salmonella maintains the integrity of its intracellular vacuole through the action of SifA, EMBO JOURNAL, Vol: 19, Pages: 3235-3249, ISSN: 0261-4189

JOURNAL ARTICLE

Brown JS, Aufauvre-Brown A, Brown J, Jennings JM, Arst H, Holden DWet al., 2000, Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity, MOLECULAR MICROBIOLOGY, Vol: 36, Pages: 1371-1380, ISSN: 0950-382X

JOURNAL ARTICLE

Dorman CJ, Dougan G, Holden DW, Williams P, Smith Het al., 2000, The activities of bacterial pathogens in vivo - Preface, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, Vol: 355, Pages: 549-550, ISSN: 0962-8436

JOURNAL ARTICLE

Shea JE, Holden DW, 2000, Signature-tagged mutagenesis helps identify virulence genes, ASM NEWS, Vol: 66, Pages: 15-20, ISSN: 0044-7897

JOURNAL ARTICLE

Unsworth KE, Holden DW, 2000, Identification and analysis of bacterial virulence genes in vivo, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, Vol: 355, Pages: 613-622, ISSN: 0962-8436

JOURNAL ARTICLE

Vazquez-Torres A, Xu YS, Jones-Carson J, Holden DW, Lucia SM, Dinauer MC, Mastroeni P, Fang FCet al., 2000, Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase, SCIENCE, Vol: 287, Pages: 1655-1658, ISSN: 0036-8075

JOURNAL ARTICLE

, 2000, Identification of Genes

PATENT

, 2000, Identification of Genes

PATENT

Chiang SL, Mekalanos JJ, Holden DW, 1999, In vivo genetic analysis of bacterial virulence, ANNUAL REVIEW OF MICROBIOLOGY, Vol: 53, Pages: 129-154, ISSN: 0066-4227

JOURNAL ARTICLE

Hensel M, Shea JE, Waterman SR, Mundy R, Nikolaus T, Banks G, Vazquez-Torres A, Gleeson C, Fang FC, Holden DWet al., 1998, Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages, MOLECULAR MICROBIOLOGY, Vol: 30, Pages: 163-174, ISSN: 0950-382X

JOURNAL ARTICLE

Hensel M, Shea JE, Raupach B, Monack D, Falkow S, Gleeson C, Kubo T, Holden DWet al., 1997, Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella Pathogenicity Island 2, MOLECULAR MICROBIOLOGY, Vol: 24, Pages: 155-167, ISSN: 0950-382X

JOURNAL ARTICLE

Mei JM, Nourbakhsh F, Ford CW, Holden DWet al., 1997, Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis, MOLECULAR MICROBIOLOGY, Vol: 26, Pages: 399-407, ISSN: 0950-382X

JOURNAL ARTICLE

HENSEL M, SHEA JE, GLEESON C, JONES MD, DALTON E, HOLDEN DWet al., 1995, SIMULTANEOUS IDENTIFICATION OF BACTERIAL VIRULENCE GENES BY NEGATIVE SELECTION, SCIENCE, Vol: 269, Pages: 400-403, ISSN: 0036-8075

JOURNAL ARTICLE

Hensel M, Tang CM, Arst HN, Holden DWet al., 1995, Regulation of fungal extracellular proteases and their role in pathogenesis, Canadian Journal of Botany, Vol: 73

JOURNAL ARTICLE

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