Imperial College London
Alternate

ProfessorDavidHolden

Faculty of Medicine, Department of Infectious Disease

Professor
 
 
 
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Contact

 

+44 (0)20 7594 3073d.holden

 
 
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Location

 

221Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

128 results found

Rytkoenen A, Holden DW, 2007, Bacterial interference of ubiquitination and deubiquitination, CELL HOST & MICROBE, Vol: 1, Pages: 13-22, ISSN: 1931-3128

Journal article

Rytkonen A, Poh J, Garmendia J, Boyle C, Thompson A, Liu M, Freemont P, Hinton JCD, Holden DWet al., 2007, SseL, a <i>Salmonella</i> deubiquitinase required for macrophage killing and virulence, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 3502-3507, ISSN: 0027-8424

Journal article

Unsworth KE, Mazurkiewicz P, Senf F, Zettl M, McNiven M, Way M, Holden DWet al., 2007, Dynamin is required for F-actin assembly and pedestal formation by enteropathogenic <i>Escherichia coli</i> (EPEC), CELLULAR MICROBIOLOGY, Vol: 9, Pages: 438-449, ISSN: 1462-5814

Journal article

Deiwick J, Salcedo SP, Boucrot E, Gilliland SM, Henry T, Petermann N, Waterman SR, Gorvel J-P, Holden DW, Meresse Set al., 2006, The translocated <i>Salmonella</i> effector proteins SseF and SseG interact and are required to establish an intracellular replication niche, INFECTION AND IMMUNITY, Vol: 74, Pages: 6965-6972, ISSN: 0019-9567

Journal article

Mazurkiewicz P, Tang CM, Boone C, Holden DWet al., 2006, Signature-tagged mutagenesis: barcoding mutants for genome-wide screens, NATURE REVIEWS GENETICS, Vol: 7, Pages: 929-939, ISSN: 1471-0056

Journal article

Barocchi MA, Rie J, Zogaj X, Hemsley C, Albiger B, Kanth A, Dahlberg S, Fernebro J, Moschioni M, Masignani V, Hultenby K, Taddei AR, Beiter K, Wartha F, von Euler A, Covacci A, Holden DW, Normark S, Rappuoli R, Henriques-Normark Bet al., 2006, A pneumococcal pilus influences virulence and host inflammatory responses, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 2857-2862, ISSN: 0027-8424

Journal article

Ygberg SE, Clements MO, Rytkönen A, Thompson A, Holden DW, Hinton JCD, Rhen Met al., 2006, Polynucleotide phosphorylase negatively controls <i>spv</i> virulence gene expression in <i>Salmonella enterica</i>, INFECTION AND IMMUNITY, Vol: 74, Pages: 1243-1254, ISSN: 0019-9567

Journal article

Mota LJ, Holden DW, 2005, FlAsHlights on bacterial virulence proteins, NATURE METHODS, Vol: 2, Pages: 898-899, ISSN: 1548-7091

Journal article

Yuste J, Botto M, Paton JC, Holden DW, Brown JSet al., 2005, Additive inhibition of complement deposition by pneumolysin and PspA facilitates <i>Streptococcus pneumoniae</i> septicemia, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 1813-1819, ISSN: 0022-1767

Journal article

Linehan SA, Rytkönen A, Yu XJ, Liu M, Holden DWet al., 2005, SlyA regulates function of <i>Salmonella</i> pathogenicity island 2 (SPI-2) and expression of SPI-2-associated genes, INFECTION AND IMMUNITY, Vol: 73, Pages: 4354-4362, ISSN: 0019-9567

Journal article

Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang ZY, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan Cet al., 2005, A glutamate-alanine-leucine (EAL) domain protein of <i>Salmonella</i> controls bacterial survival in mice, antioxidant defence and killing of macrophages:: role of cyclic diGMP, MOLECULAR MICROBIOLOGY, Vol: 56, Pages: 1234-1245, ISSN: 0950-382X

Journal article

Salcedo SP, Holden DW, 2005, Bacterial interactions with the eukaryotic secretory pathway, CURRENT OPINION IN MICROBIOLOGY, Vol: 8, Pages: 92-98, ISSN: 1369-5274

Journal article

Brown JS, Gilliland SM, Ruiz-Albert J, Holden DWet al., 2004, Characterization of pit, a <i>Streptococcus pneumoniae</i> iron uptake ABC transporter (vol 70, pg 4389, 2004), INFECTION AND IMMUNITY, Vol: 72, Pages: 6754-6754, ISSN: 0019-9567

Journal article

Petrovska L, Aspinall RJ, Barber L, Clare S, Simmons CP, Stratford R, Khan SA, Lemoine NR, Frankel G, Holden DW, Dougan Get al., 2004, <i>Salmonella enterica</i> serovar Typhimurium interaction with dendritic cells:: impact of the <i>sifA</i> gene, CELLULAR MICROBIOLOGY, Vol: 6, Pages: 1071-1084, ISSN: 1462-5814

Journal article

Unsworth KE, Way M, McNiven M, Machesky L, Holden DWet al., 2004, Analysis of the mechanisms of <i>Salmonella</i>-induced actin assembly during invasion of host cells and intracellular replication, CELLULAR MICROBIOLOGY, Vol: 6, Pages: 1041-1055, ISSN: 1462-5814

Journal article

Yu XJ, Liu M, Holden DW, 2004, SsaM and SpiC interact and regulate secretion of <i>Salmonella</i> Pathogenicity Island 2 type III secretion system effectors and translocators, MOLECULAR MICROBIOLOGY, Vol: 54, Pages: 604-619, ISSN: 0950-382X

Journal article

Brown JS, Ogunniyi AD, Woodrow MC, Holden DW, Paton JCet al., 2004, Immunization with components of two iron uptake ABC transporters protects mice against systemic <i>Streptococcus pneumoniae</i> infection (vol 69, pg 6702, 2004), INFECTION AND IMMUNITY, Vol: 72, Pages: 6755-6755, ISSN: 0019-9567

Journal article

Brown JS, Gilliland SM, Basavanna S, Holden DWet al., 2004, <i>phgABC</i>, a three-gene operon required for growth of <i>Streptococcus pneumoniae</i> in hy erosmotic medium and in vivo, INFECTION AND IMMUNITY, Vol: 72, Pages: 4579-4588, ISSN: 0019-9567

Journal article

Guignot J, Caron E, Beuzón C, Bucci C, Kagan J, Roy C, Holden DWet al., 2004, Microtubule motors control membrane dynamics of <i>Salmonella</i>-containing vacuoles, JOURNAL OF CELL SCIENCE, Vol: 117, Pages: 1033-1045, ISSN: 0021-9533

Journal article

Brown JS, Gilliland SM, Spratt BG, Holden DWet al., 2004, A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice, INFECTION AND IMMUNITY, Vol: 72, Pages: 1587-1593, ISSN: 0019-9567

Journal article

Batchelor M, Guignot J, Patel A, Cummings N, Cleary J, Knutton S, Holden DW, Connerton I, Frankel Get al., 2004, Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection, EMBO REPORTS, Vol: 5, Pages: 104-109, ISSN: 1469-221X

Journal article

Salcedo SP, Holden DW, 2003, SseG, a virulence protein that targets <i>Salmonella</i> to the Golgi network, EMBO JOURNAL, Vol: 22, Pages: 5003-5014, ISSN: 0261-4189

Journal article

Garmendia J, Beuzón CR, Ruiz-Albert J, Holden DWet al., 2003, The roles of SsrA-SsrB and OmpR-EnvZ in the regulation of genes encoding the <i>Salmonella typhimurium</i> SPI-2 type III secretion system, MICROBIOLOGY-SGM, Vol: 149, Pages: 2385-2396, ISSN: 1350-0872

Journal article

Ramos-Morales F, Prieto AI, Beuzón CR, Holden DW, Casadesús Jet al., 2003, Role for <i>Salmonella enterica</i> enterobacterial common antigen in bile resistance and virulence, JOURNAL OF BACTERIOLOGY, Vol: 185, Pages: 5328-5332, ISSN: 0021-9193

Journal article

Waterman SR, Holden DW, 2003, Functions and effectors of the <i>Salmonella</i> pathogenicity island 2 type III secretion system, CELLULAR MICROBIOLOGY, Vol: 5, Pages: 501-511, ISSN: 1462-5814

Journal article

Ruiz-Albert J, Mundy R, Yu XJ, Beuzón CR, Holden DWet al., 2003, SseA is a chaperone for the SseB and SseD translocon components of the <i>Salmonella</i> pathogenicity-island-2-encoded type III secretion system, MICROBIOLOGY-SGM, Vol: 149, Pages: 1103-1111, ISSN: 1350-0872

Journal article

Boucrot E, Beuzón CR, Holden DW, Gorvel JP, Méresse Set al., 2003, <i>Salmonella typhimurium</i> SifA effector protein requires its membrane-anchoring C-terminal hexapeptide for its biological function, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 14196-14202, ISSN: 0021-9258

Journal article

Mellado E, Dubreucq G, Mol P, Sarfati J, Paris S, Diaquin M, Holden DW, Rodriguez-Tudela JL, Latgé JPet al., 2003, Cell wall biogenesis in a double chitin synthase mutant (<i>chs</i>G<SUP>-</SUP>/<i>chs</i>E<SUP>-</SUP>) of <i>Aspergillus fumigatus</i>, FUNGAL GENETICS AND BIOLOGY, Vol: 38, Pages: 98-109, ISSN: 1087-1845

Journal article

Linehan SA, Holden DW, 2003, The interplay between <i>Salmonella typhimurium</i> and its macrophage host -: what can it teach us about innate immunity?, IMMUNOLOGY LETTERS, Vol: 85, Pages: 183-192, ISSN: 0165-2478

Journal article

Brown JS, Hussell T, Gilliland SM, Holden DW, Paton JC, Ehrenstein MR, Walport MJ, Botto Met al., 2002, The classical pathway is the dominant complement pathway required for innate immunity to <i>Streptococcus pneumoniae</i> infection in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 16969-16974, ISSN: 0027-8424

Journal article

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