Imperial College London
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ProfessorDesmondJohnston

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Clinical Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2430d.johnston

 
 
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Assistant

 

Mrs Heather Bones +44 (0)20 7594 2429

 
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Location

 

G2Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bhattarai:2019:10.1016/j.jdiacomp.2019.05.026,
author = {Bhattarai, S and Godsland, IF and Misra, S and Johnston, DG and Oliver, N},
doi = {10.1016/j.jdiacomp.2019.05.026},
journal = {Journal of Diabetes and its Complications},
pages = {634--640},
title = {Metabolic health and vascular complications in type 1 diabetes},
url = {http://dx.doi.org/10.1016/j.jdiacomp.2019.05.026},
volume = {33},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIMS: Optimal glycaemic control benefits risk of microvascular and macrovascular complications in type 1 diabetes (T1DM) but the importance of other components of metabolic health is less certain, particularly in the context of routine clinical practice. METHODS: Data for this cross-sectional analysis derived from a database covering inner North West London adult diabetes clinics. People with T1DM and with complete information for height, weight, blood pressure and serum high and low-density lipoprotein cholesterol (HDL-c and LDL-c) and triglyceride concentration measurements were included. RESULTS: Among the 920 participants, those with complications were older and had longer duration of diabetes but had similar HbA1c to people without complications. Systolic hypertension and low HDL-c were independently associated with complications. From having 0 risk factors, the prevalence of micro and macrovascular disease increased with increasing number of risk factors. Relative to those with ≥1 risk factor, those with 0 risk factors (n=179) were at lower risk of retinopathy (OR 0.6 (0.4-0.9), p=0.01) and nephropathy [OR 0.1 (0.04-0.3), p=0.002], independent of individual characteristics. CONCLUSIONS: In routine clinical management of T1DM, associations between lipid and blood pressure risk factors and prevalent micro and macrovascular disease remain, implying that more intensive risk factor management may be beneficial.
AU  - Bhattarai,S
AU  - Godsland,IF
AU  - Misra,S
AU  - Johnston,DG
AU  - Oliver,N
DO  - 10.1016/j.jdiacomp.2019.05.026
EP  - 640
PY  - 2019///
SN  - 1056-8727
SP  - 634
TI  - Metabolic health and vascular complications in type 1 diabetes
T2  - Journal of Diabetes and its Complications
UR  - http://dx.doi.org/10.1016/j.jdiacomp.2019.05.026
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31248795
UR  - http://hdl.handle.net/10044/1/71492
VL  - 33
ER  -
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