Imperial College London

Professor Daqing Ma, MD, PhD

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Anaesthesia
 
 
 
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Contact

 

+44 (0)20 3315 8495d.ma Website

 
 
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Assistant

 

Mr Faruq Noormohamed +44 (0)20 3315 8816

 
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Location

 

G3.44Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Publication Type
Year
to

308 results found

Yu ZY, Geng J, Li ZQ, Sun YB, Wang SL, Masters J, Wang DX, Guo XY, Li M, Ma Det al., 2019, Dexmedetomidine enhances ropivacaine-induced sciatic nerve injury in diabetic rats, BRITISH JOURNAL OF ANAESTHESIA, Vol: 122, Pages: 141-149, ISSN: 0007-0912

JOURNAL ARTICLE

Li T, Chen L, Zhao H, Wu L, Masters J, Han C, Hirota K, Ma Det al., 2018, Both Bupivacaine and Levobupivacaine inhibit colon cancer cell growth but not melanoma cells in vitro., J Anesth

BACKGROUND: Retrospective studies indicate that the use of regional anaesthesia causes a reduction in cancer recurrence after oncological surgery, which could be due to anaesthetic's negating effect on immunosuppression related to the surgical stress response. Local anaesthetics may also exert direct suppressive effects on malignant cells, an area where further investigation is urgently needed. METHODS: Human colon cancer cells and human melanoma cells were cultured and then treated with 1 mM bupivacaine or levobupivacaine for up to 24 or 48 h. Their migratory ability was measured by scratch assay, proliferation determined with Ki67 immunofluorescence staining, and apoptosis accessed with annexin V and PI staining on flow cytometry. The effects of bupivacaine and levobupivacaine on cellular signaling and molecular response, specifically, on endoplasmic reticulum stress (ERS), were studied with immunostaining and western blot. RESULTS: In colon cancer cells, treatment with bupivacaine and levobupivacaine significantly inhibited cell migration (**p < 0.01, ***p < 0.001; n = 4) and proliferation (**p < 0.01; n = 4), while increasing the expression of CHOP (***p < 0.001; n = 4) and decreased the expression of Grp78 (*p < 0.05; n = 4). These effects were not mirrored by melanoma cells, such that no significant increase in apoptosis was seen in either melanoma cell lines following treatment. CONCLUSION: These in vitro data suggested that both bupivacaine and levobupivacaine suppress colorectal adenocarcinoma cell proliferation and migration, which are concurrent with increased endoplasmic reticulum stress. Conversely, melanoma cells are more resilient to these two commonly used local anaesthetics. Further in vivo studies or clinical trials are needed.

JOURNAL ARTICLE

Alam A, Hana Z, Jin Z, Suen KC, Ma Det al., 2018, Surgery, neuroinflammation and cognitive impairment, EBIOMEDICINE, Vol: 37, Pages: 547-556, ISSN: 2352-3964

JOURNAL ARTICLE

Ma J, Chen Q, Li J, Zhao H, Mi E, Chen Y, Yi B, Ning J, Ma D, Lu K, Gu Jet al., 2018, Dexmedetomidine-Mediated Prevention of Renal Ischemia-Reperfusion Injury Depends in Part on Cholinergic Anti-Inflammatory Mechanisms., Anesth Analg

BACKGROUND: Organ ischemia-reperfusion injury often induces local and systemic inflammatory responses, which in turn worsen organ injury. These inflammatory responses can be regulated by the central nervous system, particularly by the vagal nerve and nicotinic acetylcholine receptors, which are the key components of cholinergic anti-inflammatory pathway. Activation of the cholinergic anti-inflammatory pathway can suppress excessive inflammatory responses and be a potential strategy for prevention of ischemia-reperfusion injury of organs including the kidney. METHODS: Vagal nerve activity, plasma acetylcholine, catecholamine and inflammatory mediators, renal tissue injury, and cell death were measured in mice with bilateral renal ischemia/reperfusion with or without treatment with dexmedetomidine (Dex), an α2-adrenergic receptor agonist. RESULTS: Dex significantly increased the discharge frequency of the cervical vagal nerve by up to 142 Hz (mean) (P < .001), and preserved kidney gross morphology and structure and attenuated cell apoptosis after ischemia-reperfusion. Furthermore, Dex also significantly increased acetylcholine release to 135.8 pmol/L (median) when compared to that (84.7 pmol/L) in the sham group (P < .001) and reduced the levels of several inflammatory mediators induced by renal ischemia/reperfusion. All the effects were abolished by vagotomy, splenectomy, or combinative administration of atipamezole, an α2-adrenergic receptor antagonist. CONCLUSIONS: Our findings suggest that Dex provides renoprotection, at least in part, through anti-inflammatory effects of the parasympathetic nervous system activation in addition to its direct actions on α2-adrenergic receptors.

JOURNAL ARTICLE

Freeman J, Crowley PD, Foley AG, Gallagher HC, Iwasaki M, Ma D, Buggy DJet al., 2018, Effect of Perioperative Lidocaine and Cisplatin on Metastasis in a Murine Model of Breast Cancer Surgery, ANTICANCER RESEARCH, Vol: 38, Pages: 5599-5606, ISSN: 0250-7005

JOURNAL ARTICLE

Liang P, Xu Y, Lan F, Ma D, Li Ket al., 2018, Decreased Cerebral Blood Flow in Mesial Thalamus and Precuneus/PCC during Midazolam Induced Sedation Assessed with ASL, NEUROINFORMATICS, Vol: 16, Pages: 403-410, ISSN: 1539-2791

JOURNAL ARTICLE

Zhao H, Huang H, Alam A, Chen Q, Suen KC, Cui J, Sun Q, Ologunde R, Zhang W, Lian Q, Ma Det al., 2018, VEGF mitigates histone-induced pyroptosis in the remote liver injury associated with renal allograft ischemia-reperfusion injury in rats, AMERICAN JOURNAL OF TRANSPLANTATION, Vol: 18, Pages: 1890-1903, ISSN: 1600-6135

JOURNAL ARTICLE

Zhang Y, Shan G-J, Zhang Y-X, Cao S-J, Zhu S-N, Li H-J, Ma D, Wang D-Xet al., 2018, Preoperative vitamin D deficiency increases the risk of postoperative cognitive dysfunction: a predefined exploratory sub-analysis, ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol: 62, Pages: 924-935, ISSN: 0001-5172

JOURNAL ARTICLE

Chang E, Wu L, Zhang J, Meng F, Soo CP, Ma Det al., 2018, Case series report on iatrogenic subglottic tracheal stenosis, British-Journal-of-Anaesthesia (BJA) Research Forum, Publisher: ELSEVIER SCI LTD, Pages: E18-E19, ISSN: 0007-0912

CONFERENCE PAPER

Zhang D-F, Su X, Meng Z-T, Li H-L, Wang D-X, Li X-Y, Maze M, Ma Det al., 2018, Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial., Ann Surg

OBJECTIVES: The aim was to compare the long-term outcomes of low-dose dexmedetomidine versus placebo in a randomized controlled trial (ChiCTR-TRC-10000802). BACKGROUND: Low-dose dexmedetomidine infusion decreased delirium occurrence within 1 week after surgery in elderly admitted to the intensive care unit (ICU) after noncardiac surgery, but the long-term outcome of this intervention is unknown. METHODS: Patients or their family members were telephone-interviewed for a 3-year follow-up data collection of survival, cognitive function assessed with the modified Telephone Interview for Cognitive Status, and quality of life evaluated with the World Health Organization Quality of Life. RESULTS: Of the 700 patients, 23 (3.3%) were lost at 3-year follow-up. The 3-year overall survival was not statistically different between the dexmedetomidine and placebo groups [114 deaths vs 122/350; hazard ratio (HR) 0.87, 95% confidence interval (CI) 0.68-1.13, P = 0.303]. The survival rates at 6 months, 1 year, and 2 years were significantly higher in the dexmedetomidine than in the placebo group (rate difference of 5.2%, 5.3%, and 6.7% respectively; all P < 0.05). The remaining 98.4% (434/441) 3-year survivors, the dexmedetomidine group, had significantly better cognitive function (mean difference 4.7, 95% CI 3.8-5.6, P < 0.0001) and quality of life (physical domain: 13.6 [10.6-16.6]; psychological domain: 15.2 [12.5-18.0]; social relationship domain: 8.1 [5.5-10.7]; environment domain: 13.3 [10.9-15.7]; all P < 0.0001) than in the placebo group. CONCLUSIONS: For elderly admitted to ICU after noncardiac surgery, low-dose dexmedetomidine infusion did not significantly change 3-year overall survival, but increased survival up to 2 years, and improved cognitive function and quality of life in 3-year survivors.

JOURNAL ARTICLE

Sun Y, Zhao H, Wang D, Ma Det al., 2018, Dexmedetomidine alleviates LPS-induced pyroptosis in astrocytes in vitro, BJA Research Forum, Publisher: ELSEVIER SCI LTD, Pages: E8-E9, ISSN: 0007-0912

CONFERENCE PAPER

Zhao H, Chen Q, Alam A, Cui J, Suen KC, Soo AP, Eguchi S, Gu J, Ma Det al., 2018, The role of osteopontin in the progression of solid organ tumour, CELL DEATH & DISEASE, Vol: 9, ISSN: 2041-4889

JOURNAL ARTICLE

Zac H, Suha A, Azeem A, Daqing Met al., Ketamine: Old Drug but New Use for Neuropathic Pain, Translational Perioperative and Pain Medicine, Vol: 5

JOURNAL ARTICLE

Ciechanowicz S, Zhao H, Chen Q, Cui J, Mi E, Mi E, Lian Q, Ma Det al., 2018, Differential effects of sevoflurane on the metastatic potential and chemosensitivity of non-small-cell lung adenocarcinoma and renal cell carcinoma in vitro, BRITISH JOURNAL OF ANAESTHESIA, Vol: 120, Pages: 368-375, ISSN: 0007-0912

JOURNAL ARTICLE

Zhao H, Alam A, Soo AP, George AJT, Ma Det al., 2018, Ischemia-Reperfusion Injury Reduces Long Term Renal Graft Survival: Mechanism and Beyond, EBIOMEDICINE, Vol: 28, Pages: 31-42, ISSN: 2352-3964

JOURNAL ARTICLE

Wu Y, Wang X-N, Wang N, Han Y, Ma D, Lu Yet al., 2018, Regularity changes of the retinal nerve fiber layer and macular ganglion cell complex in patients with the amnestic mild cognitive impairment, INTERNATIONAL JOURNAL OF NEUROSCIENCE, Vol: 128, Pages: 849-853, ISSN: 0020-7454

JOURNAL ARTICLE

Zhang Y, Li H-J, Wang D-X, Jia H-Q, Sun X-D, Pan L-H, Ye Q-S, Ouyang W, Jia Z, Zhang F-X, Guo Y-Q, Ai Y-Q, Zhao B-J, Yang X-D, Zhang Q-G, Yin N, Tan H-Y, Liu Z-H, Yu J-B, Ma Det al., 2017, Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial, BMJ OPEN, Vol: 7, ISSN: 2044-6055

JOURNAL ARTICLE

Li X, Yang J, Nie X-L, Zhang Y, Li X-Y, Li L-H, Wang D-X, Ma D-Qet al., 2017, Effect of epidural and combined spinal epidural labour analgesia on the occurrence of postpartum depression: amulticentre cohort study, 24th Annual Meeting of the Chinese-Society-of-Anesthesiology, Publisher: OXFORD UNIV PRESS, Pages: E48-E49, ISSN: 0007-0912

CONFERENCE PAPER

Zhao H, Rossaint R, Coburn M, Ma Det al., 2017, The renoprotective properties of xenon and argon in kidney transplantation, EUROPEAN JOURNAL OF ANAESTHESIOLOGY, Vol: 34, Pages: 637-640, ISSN: 0265-0215

JOURNAL ARTICLE

Liu D, Li Z, Zhang X, Zhao L, Jia J, Sun F, Wang Y, Ma D, Wei Wet al., 2017, Assessment of intracranial pressure with ultrasonographic retrobulbar optic nerve sheath diameter measurement, BMC NEUROLOGY, Vol: 17, ISSN: 1471-2377

JOURNAL ARTICLE

Zhao H, Ma D, Alam A, 2017, EXPOSURE TO ARGON AT EX VIVO STAGE PROTECTS RAT DCD RENAL ALLOGRAFT AGAINST ISCHEMIC-HYPOTHERMIC INJURY, Publisher: WILEY, Pages: 66-66, ISSN: 0934-0874

CONFERENCE PAPER

Sanders RD, Andropoulos D, Ma D, Maze Met al., 2017, Theseus, the Labyrinth, and the Minotaur of anaesthetic-induced developmental neurotoxicity, BRITISH JOURNAL OF ANAESTHESIA, Vol: 119, Pages: 453-455, ISSN: 0007-0912

JOURNAL ARTICLE

Zhang W, Zhu X, Lian Q, Ma Det al., 2017, Sevoflurane enhances proliferation, migration and invasion of cervical cancer cells in vitro, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E23-E24, ISSN: 0007-0912

CONFERENCE PAPER

Wang DX, Ma D, 2017, In reply, Anesthesiology, Vol: 127, Pages: 398-399, ISSN: 0003-3022

JOURNAL ARTICLE

Suen KC, Zhao H, Ma D, 2017, Histone release mediated necroptosis in remote lung injury following renal allograft ischemia-reperfusion injury in rats, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E25-E25, ISSN: 0007-0912

CONFERENCE PAPER

Jaffer T, Ma D, 2017, The effects of sevoflurane and propofol on ovarian cancer in vitro, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E24-E24, ISSN: 0007-0912

CONFERENCE PAPER

Zhao H, Chen Q, Suen K, Alam A, Cui J, Ma Det al., 2017, Osteopontin mediates necroptosis in remote lung injury after receiving ischemic renal allografts in rats, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E29-E29, ISSN: 0007-0912

CONFERENCE PAPER

Chen Q, Zhao H, Gu J, Ma Det al., 2017, Dexmedetomidine modulates lung alveolar macrophage polarization in vitro, British Journal of Anaesthesia (BJA) Research Forum, Publisher: OXFORD UNIV PRESS, Pages: E25-E26, ISSN: 0007-0912

CONFERENCE PAPER

Zhao H, Alam A, San C-Y, Eguchi S, Chen Q, Lian Q, Ma Det al., 2017, Molecular mechanisms of brain-derived neurotrophic factor in neuroprotection: Recent developments, BRAIN RESEARCH, Vol: 1665, Pages: 1-21, ISSN: 0006-8993

JOURNAL ARTICLE

Dobrovolsky A, Ichim TE, Ma D, Kesari S, Bogin Vet al., 2017, Xenon in the treatment of panic disorder: an open label study, JOURNAL OF TRANSLATIONAL MEDICINE, Vol: 15, ISSN: 1479-5876

JOURNAL ARTICLE

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