Publications
398 results found
Sanders RD, Sun P, Patel S, et al., 2010, Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brain, ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol: 54, Pages: 710-716, ISSN: 0001-5172
- Author Web Link
- Cite
- Citations: 205
Sanders RD, Manning HJ, Robertson NJ, et al., 2010, Preconditioning and Postinsult Therapies for Perinatal Hypoxic-Ischemic Injury at Term, ANESTHESIOLOGY, Vol: 113, Pages: 233-249, ISSN: 0003-3022
- Author Web Link
- Cite
- Citations: 44
Yang T, Benzonana L, Maze M, et al., 2010, A novel model of perinatal hypoxia/ischemia brain damage in rats, European Anaesthesiology Congress (Euroanaesthesia), Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 161-161, ISSN: 0265-0215
Grover S, Vizcaychipi MP, Zhuang L, et al., 2010, Xenon preconditioning increases expression of HSP 72 and attenuates cognitive impairment after orthopaedic surgery in mice, Euroanaesthesia 2010
Terrando N, Fidalgo AR, Vizcaychipi MP, et al., 2010, The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction, Critical Care (UK), Vol: 14, Pages: 1-9, ISSN: 1364-8535
IntroductionThe impact of pro-inflammatory cytokines on neuroinflammation and cognitive function after lipopolysaccharide (LPS) challenge remains elusive. Herein we provide evidence that there is a temporal correlation between high-mobility group box 1 (HMGB-1), microglial activation, and cognitive dysfunction. Disabling the interleukin (IL)-1 signaling pathway is sufficient to reduce inflammation and ameliorate the disability.MethodsEndotoxemia was induced in wild-type and IL-1R-/- mice by intra peritoneal injection of E. Coli LPS (1 mg/kg). Markers of inflammation were assessed both peripherally and centrally, and correlated to behavioral outcome using trace fear conditioning.ResultsIncrease in plasma tumor necrosis factor-α (TNFα) peaked at 30 minutes after LPS challenge. Up-regulation of IL-1β, IL-6 and HMGB-1 was more persistent, with detectable levels up to day three. A 15-fold increase in IL-6 and a 6.5-fold increase in IL-1β mRNA at 6 hours post intervention (P < 0.001 respectively) was found in the hippocampus. Reactive microgliosis was observed both at days one and three, and was associated with elevated HMGB-1 and impaired memory retention (P < 0.005). Preemptive administration of IL-1 receptor antagonist (IL-1Ra) significantly reduced plasma cytokines and hippocampal microgliosis and ameliorated cognitive dysfunction without affecting HMGB-1 levels. Similar results were observed in LPS-challenged mice lacking the IL-1 receptor to those seen in LPS-challenged wild type mice treated with IL-1Ra.ConclusionsThese data suggest that by blocking IL-1 signaling, the inflammatory cascade to LPS is attenuated, thereby reducing microglial activation and preventing the behavioral abnormality.
Rizvi M, Jawad N, Li Y, et al., 2010, Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells., Exp Biol Med
Limatola V, Ward P, Cattano D, et al., 2010, XENON PRECONDITIONING CONFERS NEUROPROTECTION REGARDLESS OF GENDER IN A MOUSE MODEL OF TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION, NEUROSCIENCE, Vol: 165, Pages: 874-881, ISSN: 0306-4522
- Author Web Link
- Cite
- Citations: 48
Yang J, Ma DQ, 2010, Imaging diagnosis of A H1N1 influenza with pneumonia, Chinese Journal of Radiology, Vol: 44, Pages: 219-220, ISSN: 1005-1201
- Cite
- Citations: 2
Ma DQ, 2010, Actively sum up experience of imaging diagnosis of A H1N1 influenza with pneumonia, Chinese Journal of Radiology, Vol: 44, Pages: 117-118, ISSN: 1005-1201
- Cite
- Citations: 1
Terrando N, Monaco C, Ma D, et al., 2010, Tumor necrosis factor-α triggers a cytokine cascadeyielding postoperative cognitive decline, Proc Natl Acad Sci U S A
Sanders RD, Ma D, Maze M, 2010, Argon neuroprotection, CRITICAL CARE, Vol: 14, ISSN: 1466-609X
- Author Web Link
- Cite
- Citations: 16
Cibelli M, Fidalgo AR, Terrando N, et al., 2010, Role of Interleukin-1β in Postoperative Cognitive Dysfunction, Ann Neurol, Vol: 68, Pages: 360-368
Jawad N, Rizvi M, Gua J, et al., 2009, Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an <i>in vitro</i> model of neuronal injury, NEUROSCIENCE LETTERS, Vol: 460, Pages: 232-236, ISSN: 0304-3940
- Author Web Link
- Cite
- Citations: 91
Nagy B, Fedonidis C, Photiou A, et al., 2009, CAPSAICIN-SENSITIVE PRIMARY SENSORY NEURONS IN THE MOUSE EXPRESS <i>N</i>-Acyl PHOSPHATIDYLETHANOLAMINE PHOSPHOLIPASE D, NEUROSCIENCE, Vol: 161, Pages: 572-577, ISSN: 0306-4522
- Author Web Link
- Cite
- Citations: 12
Sanders RD, Xu J, Shu Y, et al., 2009, Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats, ANESTHESIOLOGY, Vol: 110, Pages: 1077-1085, ISSN: 0003-3022
- Author Web Link
- Cite
- Citations: 331
Ma D, Lim T, Xu J, et al., 2009, Xenon Preconditioning Protects against Renal Ischemic-Reperfusion Injury <i>via</i> HIF-1α Activation, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 20, Pages: 713-720, ISSN: 1046-6673
- Author Web Link
- Open Access Link
- Cite
- Citations: 176
Qiao H, Sanders RD, Ma D, et al., 2009, Sedation improves early outcome in severely septic Sprague Dawley rats, CRITICAL CARE, Vol: 13, ISSN: 1364-8535
- Author Web Link
- Cite
- Citations: 77
Gu J, Lu K, Xia P, et al., 2009, Pharmacokinetics of Propofol and Extrahepatic UGT1A6 Gene Expression in Anhepatic Rats, PHARMACOLOGY, Vol: 84, Pages: 219-226, ISSN: 0031-7012
- Author Web Link
- Cite
- Citations: 5
Luo Y, Ma D, leong E, et al., 2008, Xenon and Sevoflurane Protect against Brain Injury in a Neonatal Asphyxia Model, ANESTHESIOLOGY, Vol: 109, Pages: 782-789, ISSN: 0003-3022
- Author Web Link
- Cite
- Citations: 83
Sanders RD, Ma D, Brooks P, et al., 2008, Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity, BRITISH JOURNAL OF ANAESTHESIA, Vol: 101, Pages: 597-609, ISSN: 0007-0912
- Author Web Link
- Cite
- Citations: 40
Sanders RD, Xu J, Shu Y, et al., 2008, General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord, ANESTHESIA AND ANALGESIA, Vol: 106, Pages: 1708-1711, ISSN: 0003-2999
- Author Web Link
- Cite
- Citations: 55
Ma D, Wan Y, Cibelli M, et al., 2007, Cognitive impairment due to surgery or postoperative complications?: <i>In Reply</i>, ANESTHESIOLOGY, Vol: 107, Pages: 849-849, ISSN: 0003-3022
- Author Web Link
- Cite
- Citations: 3
Ma DQ, Williamson P, Januszewski A, et al., 2007, Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain, Anesthesiology, Vol: 106, Pages: 746-753, ISSN: 0003-3022
Wan YJ, Xu J, Ma DQ, et al., 2007, Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus, Anesthesiology, Vol: 106, Pages: 436-443, ISSN: 0003-3022
Nogaro MC, Ma D, Maze M, 2007, Isoflurane-induced apoptotic neurodegeneration and the apoptotic pathway, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 295P-296P, ISSN: 0007-0912
Martin JL, Ma D, Hossain M, et al., 2007, Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat, BRITISH JOURNAL OF ANAESTHESIA, Vol: 98, Pages: 236-240, ISSN: 0007-0912
- Author Web Link
- Cite
- Citations: 52
Januszewski A, Ma D, Halder S, et al., 2007, Xenon protects against the apoptotic effect of isoflurane during synaptogenesis <i>in vitro</i>, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 295P-295P, ISSN: 0007-0912
- Author Web Link
- Cite
- Citations: 1
Sarvananthan T, Ma D, Maze M, et al., 2007, Xenon preconditioning attenuates cerebral infarction induced by transient middle cerebral artery occlusion (tMCAO) in adult mice, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 296P-297P, ISSN: 0007-0912
Rajakumaraswamy N, Ma D, Hossain M, et al., 2006, Neuroprotective interaction produced by xenon and dexmedetomidine on <i>in vitro</i> and <i>in vivo</i> neuronal injury models, NEUROSCIENCE LETTERS, Vol: 409, Pages: 128-133, ISSN: 0304-3940
- Author Web Link
- Cite
- Citations: 55
Ma DQ, Hossain M, Pettet GKJ, et al., 2006, Xenon preconditioning reduces brain damage from neonatal asphyxia in rats, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 26, Pages: 199-208, ISSN: 0271-678X
- Author Web Link
- Cite
- Citations: 145
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.