Dr David MacIntyre is a Senior Lecturer in Reproductive Systems Medicine. Broadly, his research is focused on understanding the role of inflammation and infection of the reproductive tract during pregnancy. He is particularly interested in understanding how vaginal microbiota and their interactions with the maternal host can influence poor pregnancy outcomes such as miscarriage, preterm premature rupture of membranes (PPROM) and preterm birth. This is achieved through a combination of classical biochemistry methods as well as “systems” modelling approaches that involve integration and analysis of genomic, transcriptomic, microbiomic and metabolic profiling data. It is hoped that will lead to improved diagnostic and predictive tools that will assist in patient stratification and ultimately, improved pregnancy outcomes.
et al., 2016, The Local and Systemic Immune Response to Intrauterine LPS in the Prepartum Mouse, Biology of Reproduction, Vol:95, ISSN:0006-3363
et al., Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage., Sci Transl Med, Vol:8