Imperial College London

Dr David MacIntyre

Faculty of MedicineDepartment of Surgery & Cancer

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2195d.macintyre Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

141 results found

Brown RG, Chan D, Lee Y, Smith A, Terzidou V, MacIntyre D, Bennett Pet al., 2018, Rescue Cervical Cerclage is Associated with Good Neonatal Outcomes in Asymptomatic Women Who Are Not Colonised by Gardnerella Vaginalis., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 112A-112A, ISSN: 1933-7191

CONFERENCE PAPER

Brown RG, Marchesi JR, Lee YS, Smith A, Lehne B, Kindinger LM, Terzidou V, Holmes E, Nicholson JK, Bennett PR, MacIntyre DAet al., 2018, Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin, BMC MEDICINE, Vol: 16, ISSN: 1741-7015

JOURNAL ARTICLE

Chan DCY, Lee YS, Bura S, Arianoglou M, Teoh TG, Collado MC, Bennett PR, MacIntyre DA, Sykes Let al., 2018, Recognition of Vaginal Microbiota by the Adaptive Maternal Immune System., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 116A-116A, ISSN: 1933-7191

CONFERENCE PAPER

Edey LF, Georgiou H, O'Dea KP, Mesiano S, Herbert BR, Lei K, Hua R, Markovic D, Waddington SN, MacIntyre D, Bennett P, Takata M, Johnson MRet al., 2018, Progesterone, the maternal immune system and the onset of parturition in the mouse, BIOLOGY OF REPRODUCTION, Vol: 98, Pages: 376-395, ISSN: 0006-3363

JOURNAL ARTICLE

Foo FL, Mahendru AA, Masini G, Fraser A, Cacciatore S, MacIntyre DA, McEniery CM, Wilkinson IB, Bennett PR, Lees CCet al., 2018, Association Between Prepregnancy Cardiovascular Function and Subsequent Preeclampsia or Fetal Growth Restriction, HYPERTENSION, Vol: 72, Pages: 442-450, ISSN: 0194-911X

JOURNAL ARTICLE

Hanton F, Foley J, Lee YS, Bennett PR, MacIntyre DAet al., 2018, Impact of Lactate Acidification on Inflammatory Pathway Activation in Vaginal Epithelial Cells., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 115A-116A, ISSN: 1933-7191

CONFERENCE PAPER

Kim SH, Binkhamis R, Cook JR, MacIntyre DA, Sykes L, Khanjani S, Bennett PR, Terzidou Vet al., 2018, A Pilot Study of Circulating miRNAs as Potential Biomarkers for Small-for-Gestational-Age Births., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 282A-282A, ISSN: 1933-7191

CONFERENCE PAPER

Kim SH, MacIntyre DA, Sykes L, Bennett PR, Terzidou Vet al., 2018, Comparing the Levels of miRNA Expression in Plasma from Blood Collected Using EDTA and Heparin Tubes, and Heparinase-Treated Plasma., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 315A-315A, ISSN: 1933-7191

CONFERENCE PAPER

Lewis H, Pruski P, Brown R, Bennett P, Takats Z, MacIntyre Det al., 2018, Rapid mucosal metabolome profiling by desorption electrospray ionization MS (DESI-MS) for prediction of preterm pre-labour rupture of membranes (PPROM), RCOG World Congress 2018, Publisher: Wiley, Pages: 24-24, ISSN: 1470-0328

CONFERENCE PAPER

Lewis HV, Pruski P, Brown RG, Kindinger L, Lee Y, Bennett P, Takats Z, MacIntyre Det al., 2018, Rapid Mucosal Metabolome Profiling by Desorption Electrospray Ionization MS (DESI-MS) for Prediction of Preterm Pre-Labour Rupture of Membranes (PPROM)., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 65A-65A, ISSN: 1933-7191

CONFERENCE PAPER

Pruski P, Lewis HV, Lee YS, Marchesi JR, Bennett PR, Takats Z, MacIntyre DAet al., 2018, Assessment of microbiota:host interactions at the vaginal mucosa interface., Methods

There is increasing appreciation of the role that vaginal microbiota play in health and disease throughout a woman's lifespan. This has been driven partly by molecular techniques that enable detailed identification and characterisation of microbial community structures. However, these methods do not enable assessment of the biochemical and immunological interactions between host and vaginal microbiota involved in pathophysiology. This review examines our current knowledge of the relationships that exist between vaginal microbiota and the host at the level of the vaginal mucosal interface. We also consider methodological approaches to microbiomic, immunologic and metabolic profiling that permit assessment of these interactions. Integration of information derived from these platforms brings the potential for biomarker discovery, disease risk stratification and improved understanding of the mechanisms regulating vaginal microbial community dynamics in health and disease.

JOURNAL ARTICLE

Rasheed ZBM, Rai RK, Anucha E, Lee YS, Sung KH, MacIntyre DA, Bennett PR, Sykes Let al., 2018, TLR3 Priming Increases TLR4-and TLR6-Mediated Pro-Inflammatory Cytokine Production in Amniocytes, Myocytes and Vaginal Epithelial Cells., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 258A-258A, ISSN: 1933-7191

CONFERENCE PAPER

Rasheed ZBM, Rai RK, Lee YS, Sung KH, MacIntyre DA, Bennett PR, Sykes Let al., 2018, The Effect of TLR3 Priming on TLR2, 4 and 6 Induced Activation of NF-kappa Band AP-1 in Human Myometrium, Amnion and Vaginal Epithelial Cells., 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 188A-188A, ISSN: 1933-7191

CONFERENCE PAPER

Al-Memar M, Bobdiwala S, Lee Y, Fourie H, Smith A, Marchesi J, Timmerman D, Bennett PR, Bourne T, MacIntyre DAet al., 2017, Association between vaginal microbiome dysbiosis and miscarriage, Publisher: WILEY, Pages: 65-65, ISSN: 1470-0328

CONFERENCE PAPER

Anucha E, Rasheed ZBM, Yun LS, MacIntyre DA, Bennett PR, Sykes Let al., 2017, The Effect of TLR3 Receptor Priming on TLR 2,4 and 6 Agonist-Induced Inflammation in Placental Explants., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 109A-109A, ISSN: 1933-7191

CONFERENCE PAPER

Bobdiwala S, Al-Memar M, Lee Y, Smith A, Marchesi J, Bennett P, Bourne T, MacIntyre Det al., 2017, Ectopic pregnancy is associated with increased vaginal bacterial diversity and reduced Lactobacillus species dominance, Publisher: WILEY, Pages: 63-64, ISSN: 1470-0328

CONFERENCE PAPER

Bray R, Cacciatore S, Jimenez B, Cartwright R, Digesu A, Fernando R, Holines E, Nicholson JK, Bennett PR, MacIntyre DA, Khullar Vet al., 2017, Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms, JOURNAL OF PROTEOME RESEARCH, Vol: 16, Pages: 4208-4216, ISSN: 1535-3893

JOURNAL ARTICLE

Brown R, Lee Y, Kindinger L, Smith A, Marchesi J, Bennett P, MacIntyre Det al., 2017, Vaginal dysbiosis following preterm prelabour rupture of the fetal membranes is associated with funisitis and the emergence of specific pathobionts, Publisher: WILEY, Pages: 31-31, ISSN: 1470-0328

CONFERENCE PAPER

Brown RG, Lee YS, Smith A, Kindinger L, Marchesi JR, Bennett PR, MacIntyre DAet al., 2017, Vaginal Dysbiosis Increases Risk of Preterm Membrane Rupture, Funisitis and Neonatal Sepsis., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 64A-64A, ISSN: 1933-7191

CONFERENCE PAPER

Cacciatore S, Tenori L, Luchinat C, Bennett PR, MacIntyre DAet al., 2017, KODAMA: an R package for knowledge discovery and data mining, BIOINFORMATICS, Vol: 33, Pages: 621-623, ISSN: 1367-4803

JOURNAL ARTICLE

Chan DCY, Lee YS, Teoh TG, Bennett PR, MacIntyre DA, Sykes Let al., 2017, A Comparison of Toll-Like Receptor 1-9 Induced Cytokine Responses in Whole Blood Collected in the First Trimester and at Term, and Matched Cord Blood., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 239A-239A, ISSN: 1933-7191

CONFERENCE PAPER

Kindinger LM, Bennett PR, Lee YS, Marchesi JR, Smith A, Cacciatore S, Holmes E, Nicholson JK, Teoh TG, Maclntyre DAet al., 2017, The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk, MICROBIOME, Vol: 5, ISSN: 2049-2618

JOURNAL ARTICLE

Lee YS, Marianoglou M, Hanton F, Brown RG, Bennett PR, MacIntyre DAet al., 2017, D-Lactic Acid Inhibits Basal Inflammatory Pathways in Human Vaginal Epithelial Cells., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 241A-241A, ISSN: 1933-7191

CONFERENCE PAPER

Lewis H, Pruski P, Kindinger L, Brown R, Lee Y, Inglese P, Bennett P, Takats Z, MacIntyre DAet al., 2017, Desorption electrospray ionisation mass spectrometry permits identification of vaginal mucosal metabolome signatures associated with preterm birth risk, Publisher: WILEY, Pages: 135-135, ISSN: 1470-0328

CONFERENCE PAPER

Lewis H, Pruski P, Kindinger L, Lee Y, Bennett P, Takats Z, MacIntyre DAet al., 2017, Relationship Between Yeast, Vaginal Microbiota Composition and Pregnancy Outcomes., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 65A-65A, ISSN: 1933-7191

CONFERENCE PAPER

MacIntyre DA, Sykes L, Bennett PR, 2017, The human female urogenital microbiome: complexity in normality, Emerging Topics in Life Sciences, Vol: 1, Pages: 363-372, ISSN: 2397-8554

JOURNAL ARTICLE

Mitra A, MacIntyre D, Lai J, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, The Impact of Excisional Treatment for Cervical Intraepithelial Neoplasia on the Vaginal Microbiota., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 89A-89A, ISSN: 1933-7191

CONFERENCE PAPER

Mitra A, MacIntyre D, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, THE VAGINAL MICROBIOTA AFTER EXCISIONAL TREATMENT FOR CERVICAL INTRAEPITHELIAL NEOPLASIA, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 979-979, ISSN: 1048-891X

CONFERENCE PAPER

Mitra A, MacIntyre DA, Mahajan V, Lee YS, Smith A, Marchesi JR, Lyons D, Bennett PR, Kyrgiou Met al., 2017, Comparison of vaginal microbiota sampling techniques: cytobrush versus swab, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Pruski P, MacIntyre DA, Lewis HV, Inglese P, Correia GDS, Hansel TT, Bennett PR, Holmes E, Takats Zet al., 2017, Medical Swab Analysis Using Desorption Electrospray Ionization Mass Spectrometry: A Noninvasive Approach for Mucosal Diagnostics, ANALYTICAL CHEMISTRY, Vol: 89, Pages: 1540-1550, ISSN: 0003-2700

JOURNAL ARTICLE

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