Imperial College London

Dr David MacIntyre

Faculty of MedicineDepartment of Surgery & Cancer

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2195d.macintyre Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

120 results found

Anucha E, Rasheed ZBM, Yun LS, MacIntyre DA, Bennett PR, Sykes Let al., 2017, The Effect of TLR3 Receptor Priming on TLR 2,4 and 6 Agonist-Induced Inflammation in Placental Explants., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 109A-109A, ISSN: 1933-7191

CONFERENCE PAPER

Bray R, Cacciatore S, Jiménez B, Cartwright R, Digesu A, Fernando R, Holmes E, Nicholson JK, Bennett PR, MacIntyre DA, Khullar Vet al., 2017, Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms., J Proteome Res

Lower urinary tract symptoms (LUTS), including urinary incontinence, urgency and nocturia, affect approximately half of women worldwide. Current diagnostic methods for LUTS are invasive and costly, while available treatments are limited by side effects leading to poor patient compliance. In this study, we aimed to identify urine metabolic signatures associated with LUTS using proton nuclear magnetic resonance ((1)H NMR) spectroscopy. A total of 214 urine samples were collected from women attending tertiary urogynecology clinics (cases; n = 176) and healthy control women attending general gynecology clinics (n = 36). Despite high variation in the urine metabolome across the cohort, associations between urine metabolic profiles and BMI, parity, overactive bladder syndrome, frequency, straining, and bladder storage were identified using KODAMA (knowledge discovery by accuracy maximization). Four distinct urinary metabotypes were identified, one of which was associated with increased urinary frequency and low BMI. Urine from these patients was characterized by increased levels of isoleucine and decreased levels of hippurate. Our study suggests that metabolic profiling of urine samples from LUTS patients offers the potential to identify differences in underlying etiology, which may permit stratification of patient populations and the design of more personalized treatment strategies.

JOURNAL ARTICLE

Brown RG, Lee YS, Smith A, Kindinger L, Marchesi JR, Bennett PR, MacIntyre DAet al., 2017, Vaginal Dysbiosis Increases Risk of Preterm Membrane Rupture, Funisitis and Neonatal Sepsis., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 64A-64A, ISSN: 1933-7191

CONFERENCE PAPER

Cacciatore S, Tenori L, Luchinat C, Bennett PR, MacIntyre DAet al., 2017, KODAMA: an R package for knowledge discovery and data mining, BIOINFORMATICS, Vol: 33, Pages: 621-623, ISSN: 1367-4803

JOURNAL ARTICLE

Chan DCY, Lee YS, Teoh TG, Bennett PR, MacIntyre DA, Sykes Let al., 2017, A Comparison of Toll-Like Receptor 1-9 Induced Cytokine Responses in Whole Blood Collected in the First Trimester and at Term, and Matched Cord Blood., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 239A-239A, ISSN: 1933-7191

CONFERENCE PAPER

Kindinger LM, Bennett PR, Lee YS, Marchesi JR, Smith A, Cacciatore S, Holmes E, Nicholson JK, Teoh TG, Maclntyre DAet al., 2017, The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk, MICROBIOME, Vol: 5, ISSN: 2049-2618

JOURNAL ARTICLE

Lee YS, Marianoglou M, Hanton F, Brown RG, Bennett PR, MacIntyre DAet al., 2017, D-Lactic Acid Inhibits Basal Inflammatory Pathways in Human Vaginal Epithelial Cells., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 241A-241A, ISSN: 1933-7191

CONFERENCE PAPER

Lewis H, Pruski P, Kindinger L, Lee Y, Bennett P, Takats Z, MacIntyre DAet al., 2017, Relationship Between Yeast, Vaginal Microbiota Composition and Pregnancy Outcomes., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 65A-65A, ISSN: 1933-7191

CONFERENCE PAPER

Mitra A, MacIntyre D, Lai J, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, The Impact of Excisional Treatment for Cervical Intraepithelial Neoplasia on the Vaginal Microbiota., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 89A-89A, ISSN: 1933-7191

CONFERENCE PAPER

Mitra A, MacIntyre DA, Mahajan V, Lee YS, Smith A, Marchesi JR, Lyons D, Bennett PR, Kyrgiou Met al., 2017, Comparison of vaginal microbiota sampling techniques: cytobrush versus swab, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Pruski P, MacIntyre DA, Lewis HV, Inglese P, Correia GDS, Hansel TT, Bennett PR, Holmes E, Takats Zet al., 2017, Medical Swab Analysis Using Desorption Electrospray Ionization Mass Spectrometry: A Noninvasive Approach for Mucosal Diagnostics, ANALYTICAL CHEMISTRY, Vol: 89, Pages: 1540-1550, ISSN: 0003-2700

JOURNAL ARTICLE

Rasheed ZBM, Lee YS, MacIntyre DA, Bennett PR, Lynne Set al., 2017, Activation of the TLR3 Receptor: A Possible Mechanism for Virally Induced Preterm Labour., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 110A-110A, ISSN: 1933-7191

CONFERENCE PAPER

Al-Memar M, Cacciatore S, Bobdiwala S, Saso S, Farren J, Bennett P, MacIntyre D, Bourne Tet al., 2016, Urine metabolomic changes by gestational age in early pregnancy and differences in the metabolome in viable pregnancies that miscarry compared to those that remain viable, Publisher: WILEY-BLACKWELL, Pages: 76-76, ISSN: 1470-0328

CONFERENCE PAPER

Al-Memar M, Caccitore S, Bobdiwala S, Saso S, Farren J, Bennett P, MacIntyre D, Bourne Tet al., 2016, Urine metabolomic changes by gestational age in early pregnancy and differences in the metabolome in viable pregnancies that miscarry compared to those that remain viable, Publisher: WILEY-BLACKWELL, Pages: E1-E1, ISSN: 1470-0328

CONFERENCE PAPER

Brown R, Kindinger L, Lee Y, Marchesi J, Bennett P, MacIntyre Det al., 2016, Characterisation of the vaginal microbiome in patients subsequently experiencing preterm prelabour rupture of membranes, Publisher: WILEY-BLACKWELL, Pages: E2-E3, ISSN: 1470-0328

CONFERENCE PAPER

Brown R, Kindinger L, Lee Y, Marchesi J, MacIntyre D, Bennett Pet al., 2016, Characterisation of the Vaginal Microbiome in Patients Subsequently Experiencing Preterm Prelabour Rupture of Membranes., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 291A-291A, ISSN: 1933-7191

CONFERENCE PAPER

Brown R, Kindinger L, Lee YS, Marchesi JR, Bennett P, MacIntyre Det al., 2016, Role of the vaginal microbiome in preterm prelabour rupture of the membranes: an observational study, Spring Meeting on Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 22-22, ISSN: 0140-6736

CONFERENCE PAPER

Brown R, Lee Y, Bains S, Bennett P, Macintyre Det al., 2016, Activator Protein 1 Is a Key Modulator of NOD1 and NOD2 Inflammatory Activation in Vaginal Epithelial Cells, 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 125A-126A, ISSN: 1933-7191

CONFERENCE PAPER

Cacciatore S, Georgakopoulou N, Jimenez B, Sykes L, Nicholson JK, Holmes E, Bennet P, MacIntyre DAet al., 2016, Urine Metabolic Phenotype Diversity in Pregnancy and Its Association with Preterm Delivery and Cervical Length., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 191A-191A, ISSN: 1933-7191

CONFERENCE PAPER

Cacciatore S, Tenori L, Luchinat C, Bennett PR, MacIntyre DAet al., 2016, KODAMA: an R package for knowledge discovery and data mining, Bioinformatics, ISSN: 1367-4803

KODAMA, a novel learning algorithm for unsupervised feature extraction, is specifically designed for analysing noisy and high-dimensional datasets. Here we present an R package of the algorithm with additional functions that allow improved interpretation of high-dimensional data. The package requires no additional software and runs on all major platforms.

JOURNAL ARTICLE

Cook J, MacIntyre D, Kim SH, Jones B, Bennett P, Terzidou Vet al., 2016, Hsa-miR-146b-3p is functionally modulated by nuclear factor-kappa B in human myometrial cells, Publisher: WILEY-BLACKWELL, Pages: 102-102, ISSN: 1470-0328

CONFERENCE PAPER

Cook J, MacIntyre D, Sykes L, Bennett P, Terzidou Vet al., 2016, Expression of specific cell-free plasma microRNAs is associated with cervical shortening in women at risk of preterm birth, Publisher: WILEY-BLACKWELL, Pages: 103-103, ISSN: 1470-0328

CONFERENCE PAPER

Cook J, MacIntyre D, Sykes L, Terzidou V, Bennett Pet al., 2016, Prediction of cervical shortening and preterm delivery using specific cell free plasma microRNAs, Publisher: WILEY-BLACKWELL, Pages: 59-60, ISSN: 1470-0328

CONFERENCE PAPER

Cook JR, MacIntyre DA, Kim SH, Jones B, Bennett PR, Terzidou Vet al., 2016, Nuclear Factor Kappa-B Functionally Modulates Hsa-miR-146b-3p in Human Myometrial Cells., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 133A-133A, ISSN: 1933-7191

CONFERENCE PAPER

Cook JR, MacIntyre DA, Sykes L, Terzidou V, Bennett PRet al., 2016, Prediction of Cervical Shortening and Preterm Delivery Using Specific Cell Free Plasma MicroRNAs., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 191A-192A, ISSN: 1933-7191

CONFERENCE PAPER

Edey LF, O'Dea KP, Herbert BR, Hua R, Waddington SN, MacIntyre DA, Bennett PR, Takata M, Johnson MRet al., 2016, The Local and Systemic Immune Response to Intrauterine LPS in the Prepartum Mouse, BIOLOGY OF REPRODUCTION, Vol: 95, ISSN: 0006-3363

JOURNAL ARTICLE

Georgakopoulou N, MacIntyre DA, Cacciatore S, Jimenez B, Sykes L, Nicholson J, Holmes E, Bennett Pet al., 2016, Early Second Trimester Plasma Metabolome Signatures of Cervical Shortening and Preterm Delivery., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 208A-208A, ISSN: 1933-7191

CONFERENCE PAPER

Holmes E, MacIntyre D, Modi N, Marchesi JRet al., 2016, Handing on health to the next generation: Early life exposures, Metabolic Phenotyping in Personalized and Public Healthcare, Pages: 213-264, ISBN: 9780128003442

© 2016 Elsevier Inc. All rights reserved. In this chapter, the role of metabolic phenotyping is described in relation to the improved understanding of the complex biochemical processes that occur in the fetus and in early life. The reasons for the importance of this type of medical supervision are discussed, and the factors that operate both in utero and in the first stages of a baby's life are given. The development of the metabolic phenotype as life begins and continues is explained, including the importance of symbiotic bacteria (the microbiome). The changing metabolic phenotyping in various conditions such as premature birth, maternal obesity, gestational diabetes, pre-eclampsia, and others is discussed in detail. Postnatal factors that influence ongoing health are then discussed in relation to metabolic processes. Finally, a strategy is proposed for monitoring infant and maternal health using metabolic phenotyping.

BOOK CHAPTER

Holmes E, Nicholson JK, Darzi AW, Lindon JCet al., 2016, Metabolic Phenotyping in Personalized and Public Healthcare, ISBN: 9780128003442

© 2016 Elsevier Inc. All rights reserved. Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream.

BOOK

Kim SH, MacIntyre DA, Hanyaloglu AC, Blanks AM, Thornton S, Bennett PR, Terzidou Vet al., 2016, The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G(alpha i) signalling, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 420, Pages: 11-23, ISSN: 0303-7207

JOURNAL ARTICLE

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