Imperial College London

Dr David MacIntyre

Faculty of MedicineDepartment of Surgery & Cancer

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2195d.macintyre Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

128 results found

Al-Memar M, Bobdiwala S, Lee Y, Fourie H, Smith A, Marchesi J, Timmerman D, Bennett PR, Bourne T, MacIntyre DAet al., 2017, Association between vaginal microbiome dysbiosis and miscarriage, Publisher: WILEY, Pages: 65-65, ISSN: 1470-0328

CONFERENCE PAPER

Anucha E, Rasheed ZBM, Yun LS, MacIntyre DA, Bennett PR, Sykes Let al., 2017, The Effect of TLR3 Receptor Priming on TLR 2,4 and 6 Agonist-Induced Inflammation in Placental Explants., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 109A-109A, ISSN: 1933-7191

CONFERENCE PAPER

Bobdiwala S, Al-Memar M, Lee Y, Smith A, Marchesi J, Bennett P, Bourne T, MacIntyre Det al., 2017, Ectopic pregnancy is associated with increased vaginal bacterial diversity and reduced Lactobacillus species dominance, Publisher: WILEY, Pages: 63-64, ISSN: 1470-0328

CONFERENCE PAPER

Bray R, Cacciatore S, Jimenez B, Cartwright R, Digesu A, Fernando R, Holines E, Nicholson JK, Bennett PR, MacIntyre DA, Khullar Vet al., 2017, Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms, JOURNAL OF PROTEOME RESEARCH, Vol: 16, Pages: 4208-4216, ISSN: 1535-3893

JOURNAL ARTICLE

Brown R, Lee Y, Kindinger L, Smith A, Marchesi J, Bennett P, MacIntyre Det al., 2017, Vaginal dysbiosis following preterm prelabour rupture of the fetal membranes is associated with funisitis and the emergence of specific pathobionts, Publisher: WILEY, Pages: 31-31, ISSN: 1470-0328

CONFERENCE PAPER

Brown RG, Lee YS, Smith A, Kindinger L, Marchesi JR, Bennett PR, MacIntyre DAet al., 2017, Vaginal Dysbiosis Increases Risk of Preterm Membrane Rupture, Funisitis and Neonatal Sepsis., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 64A-64A, ISSN: 1933-7191

CONFERENCE PAPER

Cacciatore S, Tenori L, Luchinat C, Bennett PR, MacIntyre DAet al., 2017, KODAMA: an R package for knowledge discovery and data mining, BIOINFORMATICS, Vol: 33, Pages: 621-623, ISSN: 1367-4803

JOURNAL ARTICLE

Chan DCY, Lee YS, Teoh TG, Bennett PR, MacIntyre DA, Sykes Let al., 2017, A Comparison of Toll-Like Receptor 1-9 Induced Cytokine Responses in Whole Blood Collected in the First Trimester and at Term, and Matched Cord Blood., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 239A-239A, ISSN: 1933-7191

CONFERENCE PAPER

Edey LF, Georgiou H, O'Dea KP, Mesiano S, Herbert BR, Lei K, Hua R, Markovic D, Waddington SN, MacIntyre D, Bennett P, Takata M, Johnson MRet al., 2017, Progesterone, the maternal immune system and the onset of parturition in the mouse., Biol Reprod

The role of progesterone (P4) in the regulation of the local (uterine) and systemic innate immune system, myometrial expression of connexin 43 (Cx-43) and cyclooxygenase 2 (COX-2) and the onset of parturition was examined in: 1) naïve mice delivering at term; 2) E16 mice treated with RU486 (P4-antagonist) to induce preterm parturition; and 3) in mice treated with P4 to prevent term parturition.In naïve mice, myometrial neutrophil and monocyte numbers peaked at E18 and declined with the onset of parturition. In contrast, circulating monocytes did not change and although neutrophils were increased with pregnancy, they did not change across gestation. The myometrial mRNA and protein levels of most chemokines/cytokines, Cx-43 and COX-2 increased with, but not before, parturition.With RU486-induced parturition, myometrial and systemic neutrophil numbers increased before and myometrial monocyte numbers increased with parturition only. Myometrial chemokine/cytokine mRNA abundance increased with parturition, but protein levels peaked earlier at between 4.5 and 9h post RU486. Cx-43, but not COX-2, mRNA expression and protein levels increased prior to the onset of parturition.In mice treated with P4, the gestation-linked increase in myometrial monocyte, but not neutrophil, numbers was prevented and expression of Cx-43 and COX-2 was reduced. On E20 of P4 supplementation, myometrial chemokine/cytokine and leukocyte numbers, but not Cx-43 and COX-2 expression, increased.These data show that during pregnancy P4 controls myometrial monocyte infiltration, cytokine and prolabour factor synthesis via mRNA dependent and independent mechanisms and, with prolonged P4 supplementation, P4 action is repressed resulting in increased myometrial inflammation.

JOURNAL ARTICLE

Kindinger LM, Bennett PR, Lee YS, Marchesi JR, Smith A, Cacciatore S, Holmes E, Nicholson JK, Teoh TG, Maclntyre DAet al., 2017, The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk, MICROBIOME, Vol: 5, ISSN: 2049-2618

JOURNAL ARTICLE

Lee YS, Marianoglou M, Hanton F, Brown RG, Bennett PR, MacIntyre DAet al., 2017, D-Lactic Acid Inhibits Basal Inflammatory Pathways in Human Vaginal Epithelial Cells., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 241A-241A, ISSN: 1933-7191

CONFERENCE PAPER

Lewis H, Pruski P, Kindinger L, Brown R, Lee Y, Inglese P, Bennett P, Takats Z, MacIntyre DAet al., 2017, Desorption electrospray ionisation mass spectrometry permits identification of vaginal mucosal metabolome signatures associated with preterm birth risk, Publisher: WILEY, Pages: 135-135, ISSN: 1470-0328

CONFERENCE PAPER

Lewis H, Pruski P, Kindinger L, Lee Y, Bennett P, Takats Z, MacIntyre DAet al., 2017, Relationship Between Yeast, Vaginal Microbiota Composition and Pregnancy Outcomes., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 65A-65A, ISSN: 1933-7191

CONFERENCE PAPER

MacIntyre DA, Sykes L, Bennett P, 2017, The human female urogenital microbiome: complexity in normality, Emerging Topics in Life Sciences, Vol: 1, Pages: 363-372, ISSN: 2397-8554

Microbial communities of the urogenital tract have long been recognised to play an important role in disease states. A revolution in methodological approaches is permitting the assessment of complex urogenital tract microbiota–host interactions and the metabolic and protein milieu of the mucosal interface. There is now great potential for significant advances in biomarker discovery and disease risk stratification, and for the elucidation of mechanisms underpinning the microbial community dynamics involved in urogenital tract pathology. Microbiota–host interactions in the female genital tract have a particular significance, because unlike in the male, there is direct communication between the external genitalia, the uterus and the peritoneal cavity. This review examines the microbial community composition at differing sites of the female urogenital tract and its relationship with health and disease. Key factors involved in the modulation of vaginal microbiome stability and structure, such as endocrine, immune and inflammatory pathways, are considered in the context of a woman's life cycle and disease pathogenesis.

JOURNAL ARTICLE

Mitra A, MacIntyre D, Lai J, Lee Y, Smith A, Marchesi J, Lyons D, Bennett P, Kyrgiou Met al., 2017, The Impact of Excisional Treatment for Cervical Intraepithelial Neoplasia on the Vaginal Microbiota., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 89A-89A, ISSN: 1933-7191

CONFERENCE PAPER

Mitra A, MacIntyre DA, Mahajan V, Lee YS, Smith A, Marchesi JR, Lyons D, Bennett PR, Kyrgiou Met al., 2017, Comparison of vaginal microbiota sampling techniques: cytobrush versus swab, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Pruski P, MacIntyre DA, Lewis HV, Inglese P, Correia GDS, Hansel TT, Bennett PR, Holmes E, Takats Zet al., 2017, Medical Swab Analysis Using Desorption Electrospray Ionization Mass Spectrometry: A Noninvasive Approach for Mucosal Diagnostics, ANALYTICAL CHEMISTRY, Vol: 89, Pages: 1540-1550, ISSN: 0003-2700

JOURNAL ARTICLE

Rasheed ZBM, Lee YS, MacIntyre DA, Bennett PR, Lynne Set al., 2017, Activation of the TLR3 Receptor: A Possible Mechanism for Virally Induced Preterm Labour., 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 110A-110A, ISSN: 1933-7191

CONFERENCE PAPER

Al-Memar M, Cacciatore S, Bobdiwala S, Saso S, Farren J, Bennett P, MacIntyre D, Bourne Tet al., 2016, Urine metabolomic changes by gestational age in early pregnancy and differences in the metabolome in viable pregnancies that miscarry compared to those that remain viable, Publisher: WILEY-BLACKWELL, Pages: 76-76, ISSN: 1470-0328

CONFERENCE PAPER

Al-Memar M, Caccitore S, Bobdiwala S, Saso S, Farren J, Bennett P, MacIntyre D, Bourne Tet al., 2016, Urine metabolomic changes by gestational age in early pregnancy and differences in the metabolome in viable pregnancies that miscarry compared to those that remain viable, Publisher: WILEY-BLACKWELL, Pages: E1-E1, ISSN: 1470-0328

CONFERENCE PAPER

Brown R, Kindinger L, Lee Y, Marchesi J, Bennett P, MacIntyre Det al., 2016, Characterisation of the vaginal microbiome in patients subsequently experiencing preterm prelabour rupture of membranes, Publisher: WILEY-BLACKWELL, Pages: E2-E3, ISSN: 1470-0328

CONFERENCE PAPER

Brown R, Kindinger L, Lee Y, Marchesi J, MacIntyre D, Bennett Pet al., 2016, Characterisation of the Vaginal Microbiome in Patients Subsequently Experiencing Preterm Prelabour Rupture of Membranes., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 291A-291A, ISSN: 1933-7191

CONFERENCE PAPER

Brown R, Kindinger L, Lee YS, Marchesi JR, Bennett P, MacIntyre Det al., 2016, Role of the vaginal microbiome in preterm prelabour rupture of the membranes: an observational study, Spring Meeting on Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 22-22, ISSN: 0140-6736

CONFERENCE PAPER

Brown R, Lee Y, Bains S, Bennett P, Macintyre Det al., 2016, Activator Protein 1 Is a Key Modulator of NOD1 and NOD2 Inflammatory Activation in Vaginal Epithelial Cells, 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 125A-126A, ISSN: 1933-7191

CONFERENCE PAPER

Cacciatore S, Georgakopoulou N, Jimenez B, Sykes L, Nicholson JK, Holmes E, Bennet P, MacIntyre DAet al., 2016, Urine Metabolic Phenotype Diversity in Pregnancy and Its Association with Preterm Delivery and Cervical Length., 63rd Annual Scientific Meeting of the Society-for-Reproductive-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 191A-191A, ISSN: 1933-7191

CONFERENCE PAPER

Cacciatore S, Tenori L, Luchinat C, Bennett PR, MacIntyre DAet al., 2016, KODAMA: an R package for knowledge discovery and data mining, Bioinformatics, ISSN: 1367-4803

KODAMA, a novel learning algorithm for unsupervised feature extraction, is specifically designed for analysing noisy and high-dimensional datasets. Here we present an R package of the algorithm with additional functions that allow improved interpretation of high-dimensional data. The package requires no additional software and runs on all major platforms.

JOURNAL ARTICLE

Cook J, MacIntyre D, Kim SH, Jones B, Bennett P, Terzidou Vet al., 2016, Hsa-miR-146b-3p is functionally modulated by nuclear factor-kappa B in human myometrial cells, Publisher: WILEY-BLACKWELL, Pages: 102-102, ISSN: 1470-0328

CONFERENCE PAPER

Cook J, MacIntyre D, Kim SH, Jones B, Bennett P, Terzidou Vet al., 2016, Hsa-miR-146b-3p is functionally modulated by Nuclear Factor Kappa-B in human myometrial cells, Publisher: WILEY-BLACKWELL, Pages: 162-162, ISSN: 1470-0328

CONFERENCE PAPER

Cook J, MacIntyre D, Sykes L, Bennett P, Terzidou Vet al., 2016, Expression of specific cell-free plasma microRNAs is associated with cervical shortening in women at risk of preterm birth, Publisher: WILEY-BLACKWELL, Pages: 103-103, ISSN: 1470-0328

CONFERENCE PAPER

Cook J, MacIntyre D, Sykes L, Terzidou V, Bennett Pet al., 2016, Prediction of cervical shortening and preterm delivery using specific cell free plasma microRNAs, Publisher: WILEY-BLACKWELL, Pages: 59-60, ISSN: 1470-0328

CONFERENCE PAPER

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