Imperial College London
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Professor David MacIntyre

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor in Reproduction Systems Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2195d.macintyre Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pruski:2018:10.1016/j.ymeth.2018.04.022,
author = {Pruski, P and Lewis, H and Lee, Y and Marchesi, JR and Bennett, P and Takats, Z and MacIntyre, DA},
doi = {10.1016/j.ymeth.2018.04.022},
journal = {Methods},
pages = {74--84},
title = {Assessment of microbiota:host interactions at the vaginal mucosa interface},
url = {http://dx.doi.org/10.1016/j.ymeth.2018.04.022},
volume = {149},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is increasing appreciation of the role that vaginal microbiota play in health and disease throughout a woman’s lifespan. This has been driven partly by molecular techniques that enable detailed identification and characterisation of microbial community structures. However, these methods do not enable assessment of the biochemical and immunological interactions between host and vaginal microbiota involved in pathophysiology. This review examines our current knowledge of the relationships that exist between vaginal microbiota and the host at the level of the vaginal mucosal interface. We also consider methodological approaches to microbiomic, immunologic and metabolic profiling that permit assessment of these interactions. Integration of information derived from these platforms brings the potential for biomarker discovery, disease risk stratification and improved understanding of the mechanisms regulating vaginal microbial community dynamics in health and disease.
AU  - Pruski,P
AU  - Lewis,H
AU  - Lee,Y
AU  - Marchesi,JR
AU  - Bennett,P
AU  - Takats,Z
AU  - MacIntyre,DA
DO  - 10.1016/j.ymeth.2018.04.022
EP  - 84
PY  - 2018///
SN  - 1046-2023
SP  - 74
TI  - Assessment of microbiota:host interactions at the vaginal mucosa interface
T2  - Methods
UR  - http://dx.doi.org/10.1016/j.ymeth.2018.04.022
UR  - http://hdl.handle.net/10044/1/59257
VL  - 149
ER  -
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