Imperial College London
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Professor David MacIntyre

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor in Reproduction Systems Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2195d.macintyre Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bray:2017:10.1021/acs.jproteome.7b00568,
author = {Bray, R and Cacciatore, S and Jimenez, B and Cartwright, R and Digesu, A and Fernando, R and Holmes, E and Nicholson, JK and Bennett, PR and MacIntyre, DA and Khullar, V},
doi = {10.1021/acs.jproteome.7b00568},
journal = {Journal of Proteome Research},
pages = {4208--4216},
title = {Urinary metabolic phenotyping of women with lower urinary tract symptoms},
url = {http://dx.doi.org/10.1021/acs.jproteome.7b00568},
volume = {16},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Lower urinary tract symptoms (LUTS), including urinary incontinence, urgency and nocturia, affect approximately half of women worldwide. Current diagnostic methods for LUTS are invasive and costly, while available treatments are limited by side effects leading to poor patient compliance. In this study, we aimed to identify urine metabolic signatures associated with LUTS using proton nuclear magnetic resonance (1H NMR) spectroscopy. A total of 214 urine samples were collected from women attending tertiary urogynecology clinics (cases; n = 176) and healthy control women attending general gynecology clinics (n = 36). Despite high variation in the urine metabolome across the cohort, associations between urine metabolic profiles and BMI, parity, overactive bladder syndrome, frequency, straining, and bladder storage were identified using KODAMA (knowledge discovery by accuracy maximization). Four distinct urinary metabotypes were identified, one of which was associated with increased urinary frequency and low BMI. Urine from these patients was characterized by increased levels of isoleucine and decreased levels of hippurate. Our study suggests that metabolic profiling of urine samples from LUTS patients offers the potential to identify differences in underlying etiology, which may permit stratification of patient populations and the design of more personalized treatment strategies.
AU  - Bray,R
AU  - Cacciatore,S
AU  - Jimenez,B
AU  - Cartwright,R
AU  - Digesu,A
AU  - Fernando,R
AU  - Holmes,E
AU  - Nicholson,JK
AU  - Bennett,PR
AU  - MacIntyre,DA
AU  - Khullar,V
DO  - 10.1021/acs.jproteome.7b00568
EP  - 4216
PY  - 2017///
SN  - 1535-3893
SP  - 4208
TI  - Urinary metabolic phenotyping of women with lower urinary tract symptoms
T2  - Journal of Proteome Research
UR  - http://dx.doi.org/10.1021/acs.jproteome.7b00568
UR  - http://hdl.handle.net/10044/1/51226
VL  - 16
ER  -
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