Imperial College London

DrDavidMann

Faculty of Natural SciencesDepartment of Life Sciences

Reader in Cell Cycle Control
 
 
 
//

Contact

 

+44 (0)20 7594 5302d.mann

 
 
//

Location

 

605Sir Ernst Chain BuildingSouth Kensington Campus

//

Summary

 

Summary

Research

Dr Mann's lab is applying chemical biology techniques to cancer models, particularly those relating to cell proliferation and signal transduction. Many cancers exhibit aberrant signalling and the enzymes involved can make excellent targets for therapeutic intervention.  We aim to generate chemical probes for key oncogenes and tumour suppressors to investigate their function and to act as starting points for therapeutic intervention.  For more details, click the Research tab above.

Enquiries

Enquiries are always welcome from individuals interested in pursuing research within our group.

Publications

Journals

Jamshidiha M, Lanyon-Hogg T, Sutherell C, et al., 2021, Identification of the first structurally validated covalent ligands of the small GTPase RAB27A, Rsc Medicinal Chemistry, ISSN:2632-8682

Martini S, Davis K, Faraway R, et al., 2021, A genetically-encoded crosslinker screen identifies SERBP1 as a PKC epsilon substrate influencing translation and cell division, Nature Communications, Vol:12

Watson L, Soliman TN, Davis K, et al., 2021, Co-ordinated control of the Aurora B abscission checkpoint by PKC epsilon complex assembly, midbody recruitment and retention, Biochemical Journal, Vol:478, ISSN:0264-6021, Pages:2247-2263

Vilar Compte R, Summers P, Lewis B, et al., 2021, Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy, Nature Communications, Vol:12, ISSN:2041-1723

Craven GB, Armstrong A, Mann DJ, 2020, Quantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening, Bio-protocol, Vol:10

More Publications