Dr Mann's lab is interested in cancer biology, particularly that relating to cell proliferation and signal transduction. Many cancers exhibit aberrant signal transduction and the enzymes involved can make excellent targets for therapeutic intervention. We aim to identify such targets, characterise their functions and establish techniques for regulating their activities. For more details, click the Research tab above.
Enquiries are always welcome from individuals interested in pursuing research within our group.
et al., 2019, Vinyl sulfonamide synthesis for irreversible tethering via a novel alpha-selenoether protection strategy, Medchemcomm, Vol:10, ISSN:2040-2503, Pages:158-163
et al., 2018, High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery, Angewandte Chemie-international Edition, Vol:57, ISSN:1433-7851, Pages:5257-5261
et al., 2016, N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells, Acs Chemical Biology, Vol:11, ISSN:1554-8929, Pages:2165-2176
et al., 2015, Theileria-transformed bovine leukocytes have cancer hallmarks, Trends in Parasitology, Vol:31, ISSN:1471-4922, Pages:306-314
et al., 2018, (WO2018033753) ASSAY, PCT/GB2017/052456