Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Reader in Cell Cycle Control



+44 (0)20 7594 5302d.mann




605Sir Ernst Chain BuildingSouth Kensington Campus






Dr Mann's lab is interested in cancer biology, particularly that relating to cell proliferation and signal transduction. Many cancers exhibit aberrant signal transduction and the enzymes involved can make excellent targets for therapeutic intervention.  We aim to identify such targets, characterise their functions and establish techniques for regulating their activities.  For more details, click the Research tab above.


Enquiries are always welcome from individuals interested in pursuing research within our group.



Craven GB, Affron DP, Raymond PN, et al., 2019, Vinyl sulfonamide synthesis for irreversible tethering via a novel alpha-selenoether protection strategy, Medchemcomm, Vol:10, ISSN:2040-2503, Pages:158-163

Craven GB, Affron DP, Allen CE, et al., 2018, High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery, Angewandte Chemie-international Edition, Vol:57, ISSN:1433-7851, Pages:5257-5261

Thinon E, Morales-Sanfrutos J, Mann DJ, et al., 2016, N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells, Acs Chemical Biology, Vol:11, ISSN:1554-8929, Pages:2165-2176

Tretina K, Gotia HT, Mann DJ, et al., 2015, Theileria-transformed bovine leukocytes have cancer hallmarks, Trends in Parasitology, Vol:31, ISSN:1471-4922, Pages:306-314


Mann D, Armstrong A, Craven G, et al., 2018, (WO2018033753) ASSAY, PCT/GB2017/052456

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