Publications
117 results found
Nonoo RH, Armstrong A, Mann DJ, 2012, Kinetic Template-Guided Tethering of Fragments, CHEMMEDCHEM, Vol: 7, Pages: 2082-2086, ISSN: 1860-7179
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- Citations: 42
Suntharalingam K, Hunt DJ, Duarte AA, et al., 2012, A Tri-copper(II) Complex Displaying DNA-Cleaving Properties and Antiproliferative Activity against Cancer Cells, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 15133-15141, ISSN: 0947-6539
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- Citations: 70
Thinon E, Mann D, Tate EW, 2012, Targeting N-myristoyl transferase-1 in cancer using peptide microarrays, Journal of Peptide Science, Vol: 18, Pages: S75-S75, ISSN: 1099-1387
Mak LH, Knott J, Scott KA, et al., 2012, Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases, BIOORGANIC & MEDICINAL CHEMISTRY, Vol: 20, Pages: 4371-4376, ISSN: 0968-0896
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- Citations: 11
Ohtani N, Takahashi A, Mann DJ, et al., 2012, Cellular senescence: a double-edged sword in the fight against cancer, EXPERIMENTAL DERMATOLOGY, Vol: 21, Pages: 1-4, ISSN: 0906-6705
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- Citations: 45
Child ES, Georgiades SN, Rose KN, et al., 2011, Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes., J Chem Biol, Vol: 4, Pages: 159-165
UNLABELLED: Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify potent-albeit not always selective-kinase inhibitors. Herein, in an effort to investigate the potential biological utility of metal-based compounds as inhibitors against the cancer-relevant targets mitogen-activated protein kinase and cyclin-dependent kinase 2, we explore various parameters in planar platinum(II) complexes with substituted phenanthroline ligands and aliphatic diamine chelate co-ligands, to identify combinations that yield promising inhibitory activity. The individual ligands' steric requirements as well as their pattern of hydrogen bond donors/acceptors appear to alter inhibitory potency when modulated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12154-011-0059-5) contains supplementary material, which is available to authorized users.
Lee SE, Elphick LM, Kramer HB, et al., 2011, The Chemoselective One-Step Alkylation and Isolation of Thiophosphorylated Cdk2 Substrates in the Presence of Native Cysteine, CHEMBIOCHEM, Vol: 12, Pages: 633-640, ISSN: 1439-4227
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- Citations: 6
Brooke GN, Culley RL, Dart DA, et al., 2011, FUS/TLS Is a Novel Mediator of Androgen-Dependent Cell-Cycle Progression and Prostate Cancer Growth, CANCER RESEARCH, Vol: 71, Pages: 914-924, ISSN: 0008-5472
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- Citations: 52
Anderson AA, Child ES, Prasad A, et al., 2010, Cyclin D1 and Cyclin D3 Show Divergent Responses to Distinct Mitogenic Stimulation, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 225, Pages: 638-645, ISSN: 0021-9541
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- Citations: 7
Marais A, Ji Z, Child ES, et al., 2010, Cell Cycle-dependent Regulation of the Forkhead Transcription Factor FOXK2 by CDK.Cyclin Complexes, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 35728-35739
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- Citations: 55
Child ES, Hendrychova T, McCague K, et al., 2010, A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Vol: 1803, Pages: 858-864, ISSN: 0167-4889
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- Citations: 15
Suwaki N, Child ES, Elphick LM, et al., 2010, Dose-dependent changes in cyclin D1 in response to 4-nitroquinoline 1-oxide-induced DNA damage, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol: 497, Pages: 55-61, ISSN: 0003-9861
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- Citations: 4
Bonnac L, Lee SE, Giuffredi GT, et al., 2010, Synthesis and O-Phosphorylation of 3,3,4,4-Tetrafluoro-Aryl-C-Nucleoside Analogues, Org Biomol Chem, Vol: 8, Pages: 1445-1454
Nonoo R, Mann DJ, Armstrong A, 2010, Fragment Tethering To Identify Inhibitors of Cdc25 Phosphatases, CBC-MOAC-White Rose Joint DTC Conference
Wright MH, Williams K, Jovanovic B, et al., 2010, Chemical tools for probing post-translational modification, nstitute for Chemical Biology Technology Showcase
Collins J, Mann DJ, Armstrong A, 2010, Discovery of a novel class of phosphatase inhibitor by virtual screening, SACS1 Challenges in Organic Chemistry and Chemical Biology
McCague K, Mann DJ, Armstrong A, et al., 2010, Towards a New Technique for Identifying Substrates of Protein Kinases, RSC Heterocyclic and Synthesis Group Postgraduate Symposium
McCague K, Armstrong A, Mann DJ, et al., 2010, Towards a New Technique for Identifying Substrates of Protein Kinases, RSC ISACS1: Challenges in Organic Chemistry and Chemical Biology
Patel C, Elphick LM, Mann DJ, et al., 2010, Selective Molecular Networks to Unravel Cell Signalling, 43rd IUPAC World Polymer Congress
Wright MH, Heal WP, Mann DJ, et al., 2010, Protein myristoylation in health and disease., J Chem Biol, Vol: 3, Pages: 19-35, ISSN: 1864-6166
N-myristoylation is the attachment of a 14-carbon fatty acid, myristate, onto the N-terminal glycine residue of target proteins, catalysed by N-myristoyltransferase (NMT), a ubiquitous and essential enzyme in eukaryotes. Many of the target proteins of NMT are crucial components of signalling pathways, and myristoylation typically promotes membrane binding that is essential for proper protein localisation or biological function. NMT is a validated therapeutic target in opportunistic infections of humans by fungi or parasitic protozoa. Additionally, NMT is implicated in carcinogenesis, particularly colon cancer, where there is evidence for its upregulation in the early stages of tumour formation. However, the study of myristoylation in all organisms has until recently been hindered by a lack of techniques for detection and identification of myristoylated proteins. Here we introduce the chemistry and biology of N-myristoylation and NMT, and discuss new developments in chemical proteomic technologies that are meeting the challenge of studying this important co-translational modification in living systems.
Elphick LM, Lee SE, Anderson AA, et al., 2009, Exploring the Roles of Protein Kinases Using Chemical Genetics., Future Medicinal Chemistry, Vol: 1, Pages: 1233-1241
Yamakoshi K, Takahashi A, Hirota F, et al., 2009, Real-time in vivo imaging of p16<SUP>Ink4a</SUP> reveals cross talk with p53, JOURNAL OF CELL BIOLOGY, Vol: 186, Pages: 393-407, ISSN: 0021-9525
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- Citations: 109
Lee SE, Elphick LM, Anderson AA, et al., 2009, Synthesis and reactivity of novel γ-phosphate modified ATP analogues, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 19, Pages: 3804-3807, ISSN: 0960-894X
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- Citations: 28
Elphick LM, Lee SE, Child ES, et al., 2009, A Quantitative Comparison of Wild-Type and Gatekeeper Mutant Cdk2 for Chemical Genetic Studies with ATP Analogues, CHEMBIOCHEM, Vol: 10, Pages: 1519-1526, ISSN: 1439-4227
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- Citations: 16
Ohtani N, Mann DJ, Hara E, 2009, Cellular senescence: Its role in tumor suppression and aging, CANCER SCIENCE, Vol: 100, Pages: 792-797, ISSN: 1347-9032
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- Citations: 84
Collins J, Mann DJ, 2009, Discovery of a novel class of phosphatase inhibitor, RSC Chemical Biology for Drug Discovery Conference
Karim NA, Suntharalingam K, Child ES, et al., 2009, Stabilization of G-quadruplex DNA by metal complexes: a new approach for the development of anticancer drugs., Inorganic Chemical Biology
Wright MH, Heal WP, Haslam SM, et al., 2009, Chemical tools for probing N-myristoylation, RSC-SGC Chemical Biology for Drug Discovery
Patel C, Mann DJ, Steinke J, et al., 2009, Smart Molecular Networks to Unravel Cell Signalling, London Chemical Biology Conference
Collins J, Mann DJ, Armstrong A, 2009, Discovery of a novel class of phosphatase inhibitor by virtual screening, RSC Biological and Medicinal Chemistry Symposium
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