Imperial College London

DrDespoinaMavridou

Faculty of Natural SciencesDepartment of Life Sciences

Research Fellow (MRC CDA Fellowship)
 
 
 
//

Contact

 

d.mavridou

 
 
//

Location

 

1.45Flowers buildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Mavridou:2012:10.1016/j.febslet.2012.04.055,
author = {Mavridou, DAI and Ferguson, SJ and Stevens, JM},
doi = {10.1016/j.febslet.2012.04.055},
journal = {FEBS Lett},
pages = {1702--1707},
title = {The interplay between the disulfide bond formation pathway and cytochrome c maturation in Escherichia coli.},
url = {http://dx.doi.org/10.1016/j.febslet.2012.04.055},
volume = {586},
year = {2012}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Heme attachment to c-type cytochromes in bacteria requires cysteine thiols in the CXXCH motif of the protein. The involvement of the periplasmic disulfide generation system in this process remains unclear. We undertake a systematic evaluation of the role of DsbA and DsbD in cytochrome c biogenesis in Escherichia coli and show unequivocally that DsbA is not essential for holocytochrome production under aerobic or anaerobic conditions. We also prove that DsbD is important but not essential for maturation of c-type cytochromes. We discuss the findings in the context of a model in which heme attachment to, and oxidation of, the apocytochrome are competing processes.
AU - Mavridou,DAI
AU - Ferguson,SJ
AU - Stevens,JM
DO - 10.1016/j.febslet.2012.04.055
EP - 1707
PY - 2012///
SP - 1702
TI - The interplay between the disulfide bond formation pathway and cytochrome c maturation in Escherichia coli.
T2 - FEBS Lett
UR - http://dx.doi.org/10.1016/j.febslet.2012.04.055
UR - https://www.ncbi.nlm.nih.gov/pubmed/22569094
VL - 586
ER -