Imperial College London

Professor David W. McComb

Faculty of EngineeringDepartment of Materials

Adjunct Professor



+44 (0)20 7594 6750d.mccomb Website




Royal School of MinesSouth Kensington Campus






BibTex format

author = {Zhang, C and Zhao, W and Bian, C and Hou, X and Deng, B and McComb, DW and Chen, X and Dong, Y},
doi = {10.1021/acsabm.8b00821},
journal = {ACS Applied Bio Materials},
pages = {1270--1277},
title = {Antibiotic-Derived Lipid Nanoparticles to Treat Intracellular Staphylococcus aureus},
url = {},
volume = {2},
year = {2019}

RIS format (EndNote, RefMan)

AB - Copyright © 2019 American Chemical Society. Intracellular survival of pathogenic bacteria leads to high chances of bacterial persistence and relapse in the bacteria-infected host. However, many antibiotics fail to clear the intracellular bacteria due to their low internalization by cells. In order to increase delivery of antibiotics in cells and eliminate intracellular bacteria, we developed antibiotic-derived lipid nanoparticles. First, we synthesized antibiotic-derived lipid conjugates using two widely used antibiotics including penicillin G (PenG) and levofloxacin (Levo). Then, we formulated them into antibiotic-derived lipid nanoparticles and evaluated their antibacterial effects. We found that PenG-derived phospholipid nanoparticles (PenG-PL NPs) were able to enhance cellular uptake of penicillin G as compared with free penicillin G and eliminate up to 99.9998% of ∼108.5 intracellular methicillin-sensitive Staphylococcus aureus (S. aureus) in infected A549 cells, a lung epithelial cell line. The PenG-PL NPs showed the potential for inhibiting intracellular S. aureus and are promising to be further studied for in vivo antibacterial applications.
AU - Zhang,C
AU - Zhao,W
AU - Bian,C
AU - Hou,X
AU - Deng,B
AU - McComb,DW
AU - Chen,X
AU - Dong,Y
DO - 10.1021/acsabm.8b00821
EP - 1277
PY - 2019///
SP - 1270
TI - Antibiotic-Derived Lipid Nanoparticles to Treat Intracellular Staphylococcus aureus
T2 - ACS Applied Bio Materials
UR -
VL - 2
ER -