Imperial College London

Professor David W. McComb

Faculty of EngineeringDepartment of Materials

Adjunct Professor
 
 
 
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Contact

 

+44 (0)20 7594 6750d.mccomb Website

 
 
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Location

 

Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Luo:2018:10.1007/s12274-018-2082-0,
author = {Luo, X and Zhao, W and Li, B and Zhang, X and Zhang, C and Bratasz, A and Deng, B and McComb, DW and Dong, Y},
doi = {10.1007/s12274-018-2082-0},
journal = {Nano Research},
pages = {5596--5603},
title = {Co-delivery of mRNA and SPIONs through amino-ester nanomaterials},
url = {http://dx.doi.org/10.1007/s12274-018-2082-0},
volume = {11},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - © 2018, Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature. Nanoparticles have been widely explored for combined therapeutic and diagnostic applications. For example, lipid-based nanoparticles have been used to encapsulate multiple types of agents and achieve multi-functions. Herein, we enabled a co-delivery of mRNA molecules and superparamagnetic iron oxide nanoparticles (SPIONs) by using an amino-ester lipid-like nanomaterial. An orthogonal experimental design was used to identify the optimal formulation. The optimal formulation, MPA-Ab-8 LLNs, not only showed high encapsulation of both mRNA and SPIONs, but also increased the r2 relaxivity of SPIONs by more than 1.5-fold in vitro. MPA-Ab-8 LLNs effectively delivered mRNA and SPIONs into cells, and consequently induced high protein expression as well as strong MRI contrast. Consistent herewith, we observed both mRNA-mediated protein expression and an evident negative contrast enhancement of MRI signal in mice. In conclusion, amino-ester nanomaterials demonstrate great potential as delivery vehicles for theranostic applications.
AU - Luo,X
AU - Zhao,W
AU - Li,B
AU - Zhang,X
AU - Zhang,C
AU - Bratasz,A
AU - Deng,B
AU - McComb,DW
AU - Dong,Y
DO - 10.1007/s12274-018-2082-0
EP - 5603
PY - 2018///
SN - 1998-0124
SP - 5596
TI - Co-delivery of mRNA and SPIONs through amino-ester nanomaterials
T2 - Nano Research
UR - http://dx.doi.org/10.1007/s12274-018-2082-0
VL - 11
ER -