Imperial College London
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ProfessorDashaNicholls

Faculty of Medicine, Department of Brain Sciences

Professor of Child and Adolescent Psychiatrist
 
 
 
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Contact

 

d.nicholls

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{O'Connor:2016:10.1177/0884533615627267,
author = {O'Connor, G and Nicholls, D and Hudson, L and Singhal, A},
doi = {10.1177/0884533615627267},
journal = {Nutr Clin Pract},
pages = {681--689},
title = {Refeeding Low Weight Hospitalized Adolescents With Anorexia Nervosa: A Multicenter Randomized Controlled Trial},
url = {http://dx.doi.org/10.1177/0884533615627267},
volume = {31},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Refeeding patients with anorexia nervosa (AN) is associated with high morbidity and mortality. A lack of evidence from interventional studies has hindered refeeding practice and led to worldwide disparities in management recommendations. In the first randomized controlled trial in this area, we tested the hypothesis that refeeding adolescents with AN with a higher energy intake than what many guidelines recommend improved anthropometric outcomes without adversely affecting cardiac and biochemical markers associated with refeeding. MATERIALS AND METHODS: Participants aged 10-16 years with a body mass index (BMI) <78% of the median (mBMI) for age and sex were recruited from 6 UK hospitals and randomly allocated to start refeeding at 1200 kcal/d (n = 18, intervention) or 500 kcal/d (n = 18, control). RESULTS: Compared with controls, adolescents randomized to high energy intake had greater weight gain (mean difference between groups after 10 days of refeeding, -1.2% mBMI; 95% confidence interval, -2.4% to 0.0%; P = .05), but randomized groups did not differ statistically in QTc interval and other outcomes. The nadir in postrefeeding phosphate concentration was significantly related to percentage mBMI at the start of refeeding (baseline; P = .04) and baseline white blood cell count (P = .005) but not to baseline energy intake (P = .08). CONCLUSIONS: Refeeding adolescents with AN with a higher energy intake was associated with greater weight gain but without an increase in complications associated with refeeding when compared with a more cautious refeeding protocol-thus challenging current refeeding recommendations.
AU  - O'Connor,G
AU  - Nicholls,D
AU  - Hudson,L
AU  - Singhal,A
DO  - 10.1177/0884533615627267
EP  - 689
PY  - 2016///
SN  - 0884-5336
SP  - 681
TI  - Refeeding Low Weight Hospitalized Adolescents With Anorexia Nervosa: A Multicenter Randomized Controlled Trial
T2  - Nutr Clin Pract
UR  - http://dx.doi.org/10.1177/0884533615627267
VL  - 31
ER  -
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