Publications
1392 results found
GLEITER CH, THIAGARAJAN AB, NUTT DJ, 1988, AN ANIMAL-MODEL FOR THE CNS ACTIONS OF ELECTRO-CONVULSIVE SHOCK (ECS), CLINICAL PHARMACOLOGY & THERAPEUTICS, Vol: 43, Pages: 177-177, ISSN: 0009-9236
LISTER RG, NUTT DJ, 1988, INTERACTIONS OF THE IMIDAZODIAZEPINE RO-15-4513 WITH CHEMICAL CONVULSANTS, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 93, Pages: 210-214, ISSN: 0007-1188
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- Citations: 41
GLEITER CH, NUTT DJ, 1988, REPEATED ELECTROCONVULSIVE SHOCK DOES NOT CHANGE [H-3] PAROXETINE BINDING TO THE 5-HT UPTAKE SITE IN RAT CORTICAL MEMBRANES, PSYCHOPHARMACOLOGY, Vol: 95, Pages: 68-70, ISSN: 0033-3158
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- Citations: 18
NUTT DJ, TAYLOR SC, LITTLE HJ, et al., 1988, CHANGES IN BENZODIAZEPINE GABA RECEPTOR COMPLEX FUNCTION IN BENZODIAZEPINE-TOLERANT MICE, PSYCHOPHARMACOLOGY, Vol: 95, Pages: 407-412, ISSN: 0033-3158
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- Citations: 19
GLEITER CH, NUTT DJ, 1988, REPEATED ELECTROCONVULSIVE SHOCK INCREASES THE NUMBER OF [H-3] DESIPRAMINE BINDING-SITES IN RAT CEREBRAL-CORTEX, PSYCHOPHARMACOLOGY, Vol: 96, Pages: 426-427, ISSN: 0033-3158
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- Citations: 6
Lister RG, Nutt DJ, 1988, RO 15-4513 and its interaction with ethanol., Adv Alcohol Subst Abuse, Vol: 7, Pages: 119-123, ISSN: 0270-3106
It has recently been claimed that RO 15-4513 selectively opposes some of the behavioral actions of ethanol. Our studies on the intrinsic effects of this compound have shown it to be proconvulsant and to reduce exploratory behavior in mice. In these respects RO 15-4513 resembles a benzodiazepine receptor partial inverse agonist. Such intrinsic actions may well explain its alcohol-antagonizing properties, and argue against its potential in humans. In addition to partially reversing the effects of ethanol, RO 15-4513 also partially reverses the behavioral effect of a barbiturate and completely reverses the effects of a benzodiazepine.
NUTT DJ, LISTER RG, 1988, STRAIN DIFFERENCES IN RESPONSE TO A BENZODIAZEPINE RECEPTOR INVERSE AGONIST (FG 7142) IN MICE, PSYCHOPHARMACOLOGY, Vol: 94, Pages: 435-436, ISSN: 0033-3158
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- Citations: 37
LISTER RG, DURCAN MJ, NUTT DJ, et al., 1988, PHARMACOLOGICAL ANTAGONISM OF ETHANOLS BEHAVIORAL-EFFECTS - A COMPARISON BETWEEN BENZODIAZEPINE RECEPTOR INVERSE AGONISTS AND ALPHA-2 RECEPTOR ANTAGONISTS, PSYCHOPHARMACOLOGY, Vol: 96, Pages: S35-S35, ISSN: 0033-3158
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- Citations: 2
THIAGARAJAN AB, GLEITER CH, NUTT DJ, 1988, ELECTROCONVULSIVE SHOCK DOES NOT INCREASE PLASMA-INSULIN IN RATS, CONVULSIVE THERAPY, Vol: 4, Pages: 292-296, ISSN: 0749-8055
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- Citations: 7
GLEITER CH, NUTT DJ, 1988, A SINGLE ELECTROCONVULSIVE SHOCK SUBSTANTIALLY LOWERS BLOOD-GLUCOSE LEVELS IN OBESE MICE (C57BL/6J OB/OB), PSYCHOPHARMACOLOGY, Vol: 95, Pages: 287-288, ISSN: 0033-3158
Nutt DJ, Lister RG, 1988, Strain differences in response to a benzodiazepine receptor inverse agonist (FG 7142) in mice., Psychopharmacology (Berl), Vol: 94, Pages: 335-336, ISSN: 0033-3158
NUTT DJ, COSTELLO MJ, 1988, RAPID INDUCTION OF LORAZEPAM DEPENDENCE AND REVERSAL WITH FLUMAZENIL, LIFE SCIENCES, Vol: 43, Pages: 1045-1053, ISSN: 0024-3205
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- Citations: 57
Risher-Flowers D, Adinoff B, Ravitz B, et al., 1988, Circadian rhythms of cortisol during alcohol withdrawal., Adv Alcohol Subst Abuse, Vol: 7, Pages: 37-41, ISSN: 0270-3106
The authors have investigated the function of the hypothalamic-pituitary-adrenocortical (HPA) axis during and after withdrawal from alcohol. 24 hour rhythms of cortisol were abnormal in that elevated levels were seen throughout the day in patients with moderate to severe, but not mild, withdrawal. This abnormality of circadian secretion of cortisol, which is similar to that seen in Cushing's syndrome and post-operative trauma, returned to normal after a period of one week of abstinence on their in-patient ward. Such excessive secretion of cortisol may explain some of the complications of chronic alcoholism.
GLEITER CH, DECKERT J, NUTT DJ, 1988, CHANGES IN CAFFEINE SEIZURE THRESHOLD AFTER ELECTROCONVULSIVE SHOCK, PSYCHOPHARMACOLOGY, Vol: 95, Pages: 544-545, ISSN: 0033-3158
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- Citations: 3
Linnoila M, Mefford I, Nutt D, et al., 1987, NIH conference. Alcohol withdrawal and noradrenergic function., Ann Intern Med, Vol: 107, Pages: 875-889, ISSN: 0003-4819
Alcohol withdrawal syndrome is characterized by signs of overactivity of the sympathetic nervous system. Biochemical studies indicate that increased release of norepinephrine is associated with certain symptoms of alcohol withdrawal, and the severity of the withdrawal symptoms correlates positively with the amount of norepinephrine released. In the rat, the brain epinephrine concentration is reduced by alcohol, a phenomenon probably associated with both the intoxicating and rewarding effects of alcohol intake. Furthermore, intoxicating effects of alcohol can be reversed by inhibiting epinephrine synthesis in the rat brain. In this species, alcohol withdrawal is associated with profound depletion of epinephrine in the hypothalamus. When clonidine, a norepinephrine alpha-2-receptor agonist, was infused in alcoholics, these receptors were found to be subsensitive during alcohol withdrawal, and this subsensitivity may contribute to the syndrome. Repeated withdrawals may lead to "kindling" and thus further enhancement of noradrenergic overactivity. Pituitary responsiveness to corticotropin-releasing hormone, which is a central regulator of stress responses and increases the firing rate of brain noradrenergic neurons, is altered during alcohol withdrawal.
LINNOILA M, MEFFORD I, NUTT D, et al., 1987, ALCOHOL-WITHDRAWAL AND NORADRENERGIC FUNCTION, ANNALS OF INTERNAL MEDICINE, Vol: 107, Pages: 875-889, ISSN: 0003-4819
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- Citations: 143
NUTT D, GLUE P, STEWART A, 1987, PLATELET MONAMINE RECEPTOR-BINDING IN ALCOHOLICS DURING WITHDRAWAL, BRITISH JOURNAL OF ADDICTION, Vol: 82, Pages: 1253-1255, ISSN: 0952-0481
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- Citations: 1
LITTLE HJ, NUTT DJ, TAYLOR SC, 1987, BIDIRECTIONAL EFFECTS OF CHRONIC TREATMENT WITH AGONISTS AND INVERSE AGONISTS AT THE BENZODIAZEPINE RECEPTOR, BRAIN RESEARCH BULLETIN, Vol: 19, Pages: 371-378, ISSN: 0361-9230
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- Citations: 65
GLEITER CH, NUTT DJ, COSTELLO M, et al., 1987, ANTIDIABETIC EFFECT OF ELECTROSHOCK (ECS) IN OB/OB MICE, JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 27, Pages: 716-716, ISSN: 0091-2700
NUTT D, COSTELLO M, 1987, FLUMAZENIL AND BENZODIAZEPINE WITHDRAWAL, LANCET, Vol: 2, Pages: 463-463, ISSN: 0140-6736
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- Citations: 4
, 1987, Flumazenil and benzodiazepine withdrawal., Lancet, Vol: 2, ISSN: 0140-6736
NUTT DJ, COWEN PJ, 1987, DIAZEPAM ALTERS BRAIN 5-HT FUNCTION IN MAN - IMPLICATIONS FOR THE ACUTE AND CHRONIC EFFECTS OF BENZODIAZEPINES, PSYCHOLOGICAL MEDICINE, Vol: 17, Pages: 601-607, ISSN: 0033-2917
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- Citations: 48
GEORGE DT, LADENHEIM JA, NUTT DJ, 1987, EFFECT OF PREGNANCY ON PANIC ATTACKS, AMERICAN JOURNAL OF PSYCHIATRY, Vol: 144, Pages: 1078-1079, ISSN: 0002-953X
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- Citations: 67
NUTT DJ, 1987, PLATELET ALPHA2-ADRENOCEPTOR BINDING DOES NOT PREDICT BRAIN ALPHA2-ADRENOCEPTOR FUNCTION, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 24, Pages: 122-122, ISSN: 0306-5251
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- Citations: 10
NUTT DJ, LISTER RG, 1987, THE EFFECT OF THE IMIDAZODIAZEPINE RO-15-4513 ON THE ANTICONVULSANT EFFECTS OF DIAZEPAM, SODIUM PENTOBARBITAL AND ETHANOL, BRAIN RESEARCH, Vol: 413, Pages: 193-196, ISSN: 0006-8993
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- Citations: 64
LISTER RG, NUTT DJ, 1987, IS RO-15-4513 A SPECIFIC ALCOHOL ANTAGONIST, TRENDS IN NEUROSCIENCES, Vol: 10, Pages: 223-225, ISSN: 0166-2236
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- Citations: 120
NUTT DJ, 1987, ABNORMAL ALPHA-2-ADRENOCEPTOR-MEDICATED ENDOCRINE RESPONSE IN PANIC DISORDER, NEUROENDOCRINOLOGY LETTERS, Vol: 9, Pages: 210-210, ISSN: 0172-780X
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- Citations: 1
RAVITZ B, TOWLE M, NUTT D, et al., 1987, PSYCHOLOGICAL EFFECTS OF ETHANOL IN NORMAL-MALE VOLUNTEERS, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Vol: 11, Pages: 219-219, ISSN: 0145-6008
NUTT DJ, LISTER R, 1987, STUDIES ON THE PUTATIVE ALCOHOL ANTAGONIST RO15-4513, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Vol: 11, Pages: 218-218, ISSN: 0145-6008
GEORGE DT, NUTT DJ, LINNOILA M, 1987, ARE ALCOHOLICS SUBSENSITIVE TO LACTATE, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Vol: 11, Pages: 215-215, ISSN: 0145-6008
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