Imperial College London
Alternate

Professor David Nutt DM, FRCP, FRCPsych, FSB, FMedSci

Faculty of Medicine, Department of Brain Sciences

The Edmond J Safra Chair in Neuropsychopharmacology
 
 
 
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Contact

 

d.nutt

 
 
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Location

 

Burlington Danes BuildingBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dukart:2018:10.1038/s41598-018-22444-0,
author = {Dukart, J and Holiga,  and Chatham, C and Hawkins, P and Forsyth, A and McMillan, R and Myers, J and Lingford-Hughes, AR and Nutt, DJ and Merlo-Pich, E and Risterucci, C and Boak, L and Umbricht, D and Schobel, S and Liu, T and Mehta, MA and Zelaya, FO and Williams, SC and Brown, G and Paulus, M and Honey, GD and Muthukumaraswamy, S and Hipp, J and Bertolino, A and Sambataro, F},
doi = {10.1038/s41598-018-22444-0},
journal = {Scientific Reports},
title = {Cerebral blood flow predicts differential neurotransmitter activity},
url = {http://dx.doi.org/10.1038/s41598-018-22444-0},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link of observed alterations to specific neurophysiological processes. In particular, the sensitivity of cerebral blood flow to activity changes in specific neurotransmitter systems remains unclear. We address this question by probing cerebral blood flow in healthy volunteers using seven established drugs with known dopaminergic, serotonergic, glutamatergic and GABAergic mechanisms of action. We use a novel framework aimed at disentangling the observed effects to contribution from underlying neurotransmitter systems. We find for all evaluated compounds a reliable spatial link of respective cerebral blood flow changes with underlying neurotransmitter receptor densities corresponding to their primary mechanisms of action. The strength of these associations with receptor density is mediated by respective drug affinities. These findings suggest that cerebral blood flow is a sensitive brain-wide in-vivo assay of metabolic demands across a variety of neurotransmitter systems in humans.
AU  - Dukart,J
AU  - Holiga,
AU  - Chatham,C
AU  - Hawkins,P
AU  - Forsyth,A
AU  - McMillan,R
AU  - Myers,J
AU  - Lingford-Hughes,AR
AU  - Nutt,DJ
AU  - Merlo-Pich,E
AU  - Risterucci,C
AU  - Boak,L
AU  - Umbricht,D
AU  - Schobel,S
AU  - Liu,T
AU  - Mehta,MA
AU  - Zelaya,FO
AU  - Williams,SC
AU  - Brown,G
AU  - Paulus,M
AU  - Honey,GD
AU  - Muthukumaraswamy,S
AU  - Hipp,J
AU  - Bertolino,A
AU  - Sambataro,F
DO  - 10.1038/s41598-018-22444-0
PY  - 2018///
SN  - 2045-2322
TI  - Cerebral blood flow predicts differential neurotransmitter activity
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-018-22444-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29511260
UR  - http://hdl.handle.net/10044/1/57720
VL  - 8
ER  -
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