Imperial College London
Alternate

Dr David R Owen MD PhD

Faculty of Medicine, Department of Brain Sciences

Reader in Molecular Pharmacology and Experimental Medicine
 
 
 
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Contact

 

+44 (0)20 3313 6195d.owen Website

 
 
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Location

 

G20AICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fujita:2017:10.1186/s13550-017-0334-8,
author = {Fujita, M and Kobayashi, M and Ikawa, M and Gunn, RN and Rabiner, EA and Owen, DR and Zoghbi, SS and Haskali, MB and Telu, S and Pike, VW and Innis, RB},
doi = {10.1186/s13550-017-0334-8},
journal = {EJNMMI Research},
title = {Comparison of four (11)C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios.},
url = {http://dx.doi.org/10.1186/s13550-017-0334-8},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. (11)C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four (11)C-labeled ligands-(R)-PK11195, PBR28, DPA-713, and ER176-to quantify TSPO in healthy humans. For all of these ligands, BP ND (specific-to-non-displaceable ratio of distribution volumes) was measured by partially blocking specific binding with XNBD173 administration. In high-affinity binders, DPA-713 showed the highest BP ND of 7.3 followed by ER176 (4.2), PBR28 (1.2), and PK11195 (0.8). Only ER176 allows the inclusion of low-affinity binders because of little influence of radiometabolites and high BP ND. If inclusion of all three genotypes is important for study logistics, ER176 is the best of these four radioligands for studying neuroinflammation.
AU  - Fujita,M
AU  - Kobayashi,M
AU  - Ikawa,M
AU  - Gunn,RN
AU  - Rabiner,EA
AU  - Owen,DR
AU  - Zoghbi,SS
AU  - Haskali,MB
AU  - Telu,S
AU  - Pike,VW
AU  - Innis,RB
DO  - 10.1186/s13550-017-0334-8
PY  - 2017///
SN  - 2191-219X
TI  - Comparison of four (11)C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios.
T2  - EJNMMI Research
UR  - http://dx.doi.org/10.1186/s13550-017-0334-8
UR  - http://hdl.handle.net/10044/1/52003
VL  - 7
ER  -
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