Imperial College London

Diego A. OyarzĂșn

Faculty of Natural SciencesDepartment of Mathematics

Research Fellow



d.oyarzun Website




6M48Huxley BuildingSouth Kensington Campus





Diego leads the Biomolecular Control Group at Imperial College, focused on the analysis and design of biochemical circuits in living cells. He holds a Young Investigator Grant from the Human Frontier Science Program and previously held a Marie Curie Fellowship and an Imperial College Research Fellowship in Biomathematics.

In 2016 Diego was appointed as Global Future Council Fellow by the World Economic Forum to serve in the Council on Future of Biotechnologies. In 2017 he was selected as one of the 100 Young Global Changers by the Think 20 Summit, mandated by the G20 presidency.

Diego also serves in the Scientific Advisory Board for the WEF Center for the Fourth Industrial Revolution in San Francisco and the EPSRC Early Career Forum in Mathematical Sciences. He is an Associate Editor for the journals Frontiers in Synthetic Biology and Microbial Cell Factories.

More information in his research website.

Selected Publications

Journal Articles

Liu D, Mannan AA, Han Y, et al., 2018, Dynamic metabolic control: towards precision engineering of metabolism., J Ind Microbiol Biotechnol

Mannan AA, Liu D, Zhang F, et al., 2017, Fundamental Design Principles for Transcription-Factor-Based Metabolite Biosensors, Acs Synthetic Biology, Vol:6, ISSN:2161-5063, Pages:1851-1859

Weisse AY, Mannan AA, Oyarzun DA, 2016, Signaling Tug-of-War Delivers the Whole Message, Cell Systems, Vol:3, ISSN:2405-4712, Pages:414-416

Oyarzun DA, Chaves M, 2015, Design of a bistable switch to control cellular uptake, Journal of the Royal Society Interface, Vol:12, ISSN:1742-5689

Sootla A, Oyarzun D, Angeli D, et al., 2016, Shaping pulses to control bistable systems: Analysis, computation and counterexamples, Automatica, Vol:63, ISSN:0005-1098, Pages:254-264

Weisse AY, Oyarzun DA, Danos V, et al., 2015, Mechanistic links between cellular trade-offs, gene expression, and growth, Proceedings of the National Academy of Sciences of the United States of America, Vol:112, ISSN:0027-8424, Pages:E1038-E1047

Waldherr S, Oyarzun DA, Bockmayr A, 2015, Dynamic optimization of metabolic networks coupled with gene expression, Journal of Theoretical Biology, Vol:365, ISSN:0022-5193, Pages:469-485

Oyarzun DA, Bramhall JL, Lopez-Caamal F, et al., 2014, The EGFR demonstrates linear signal transmission, Integrative Biology, Vol:6, ISSN:1757-9694, Pages:736-742

Oyarzun DA, Lugagne J-B, Stan G-BV, 2015, Noise Propagation in Synthetic Gene Circuits for Metabolic Control, Acs Synthetic Biology, Vol:4, ISSN:2161-5063, Pages:116-125

Oyarzun DA, Ingalls BP, Middleton RH, et al., 2009, Sequential Activation of Metabolic Pathways: a Dynamic Optimization Approach, Bulletin of Mathematical Biology, Vol:71, ISSN:0092-8240, Pages:1851-1872

Oyarzun DA, Stan G-BV, 2013, Synthetic gene circuits for metabolic control: design trade-offs and constraints, Journal of the Royal Society Interface, Vol:10, ISSN:1742-5689

Oyarzun DA, Chaves M, Hoff-Hoffmeyer-Zlotnik M, 2012, Multistability and oscillations in genetic control of metabolism, Journal of Theoretical Biology, Vol:295, ISSN:0022-5193, Pages:139-153

More Publications