Imperial College London

Diego A. Oyarzún

Faculty of Natural SciencesDepartment of Mathematics

Research Fellow



d.oyarzun Website




6M48Huxley BuildingSouth Kensington Campus





Diego leads the Biomolecular Control Group at Imperial College, focused on the analysis and design of biochemical circuits in living cells. He holds a Young Investigator Grant from the Human Frontier Science Program and previously held a Marie Curie Fellowship and an Imperial College Research Fellowship in Biomathematics.

In 2016 Diego was appointed Global Future Council Fellow by the World Economic Forum to serve in the Council on Biotechnologies. In 2017 he was selected as one of the 100 Young Global Changers by the Think 20 Summit and the G20 presidency.

Diego also serves in the Scientific Advisory Board for the WEF Center for the Fourth Industrial Revolution in San Francisco and the EPSRC Early Career Forum in Mathematical Sciences. He is an Associate Editor for the journals Frontiers in Synthetic Biology and Microbial Cell Factories.

More information in his research website.

News: In January 2019 Diego will relocate to the University of Edinburgh, jointly affiliated with the School of Biological Sciences and the School of Informatics. Please get in touch for PhD opportunities.

Selected Publications

Journal Articles

Chaves M, Oyarzún DA, 2019, Dynamics of complex feedback architectures in metabolic pathways, Automatica, Vol:99, ISSN:0005-1098, Pages:323-332

Chaves M, Oyarzún DA, Gouzé J-L, 2018, Analysis of a genetic-metabolic oscillator with piecewise linear models., J Theor Biol, Vol:462, Pages:259-269

O'Day E, Hosta-Rigau L, Oyarzún DA, et al., 2018, Are we there yet? How and when specific biotechnologies will improve human health, Biotechnology Journal, ISSN:1860-6768, Pages:e1800195-e1800195

de Lorenzo V, Prather KL, Chen G-Q, et al., 2018, The power of synthetic biology for bioproduction, remediation and pollution control, EMBO Reports, Vol:19, ISSN:1469-221X

Beguerisse-Díaz M, Bosque G, Oyarzún D, et al., 2018, Flux-dependent graphs for metabolic networks., Npj Syst Biol Appl, Vol:4, ISSN:2056-7189

Mannan AA, Liu D, Zhang F, et al., 2017, Fundamental Design Principles for Transcription-Factor-Based Metabolite Biosensors, Acs Synthetic Biology, Vol:6, ISSN:2161-5063, Pages:1851-1859

Sootla A, Oyarzun D, Angeli D, et al., 2016, Shaping pulses to control bistable systems: Analysis, computation and counterexamples, Automatica, Vol:63, ISSN:0005-1098, Pages:254-264

Oyarzun DA, Chaves M, 2015, Design of a bistable switch to control cellular uptake, Journal of the Royal Society Interface, Vol:12, ISSN:1742-5689

Weisse AY, Oyarzun DA, Danos V, et al., 2015, Mechanistic links between cellular trade-offs, gene expression, and growth, Proceedings of the National Academy of Sciences of the United States of America, Vol:112, ISSN:0027-8424, Pages:E1038-E1047

Oyarzun DA, Lugagne J-B, Stan G-BV, 2015, Noise Propagation in Synthetic Gene Circuits for Metabolic Control, Acs Synthetic Biology, Vol:4, ISSN:2161-5063, Pages:116-125

Waldherr S, Oyarzun DA, Bockmayr A, 2015, Dynamic optimization of metabolic networks coupled with gene expression, Journal of Theoretical Biology, Vol:365, ISSN:0022-5193, Pages:469-485

Oyarzun DA, Stan G-BV, 2013, Synthetic gene circuits for metabolic control: design trade-offs and constraints, Journal of the Royal Society Interface, Vol:10, ISSN:1742-5689

Oyarzun DA, Chaves M, Hoff-Hoffmeyer-Zlotnik M, 2012, Multistability and oscillations in genetic control of metabolism, Journal of Theoretical Biology, Vol:295, ISSN:0022-5193, Pages:139-153

Oyarzun DA, Ingalls BP, Middleton RH, et al., 2009, Sequential Activation of Metabolic Pathways: a Dynamic Optimization Approach, Bulletin of Mathematical Biology, Vol:71, ISSN:0092-8240, Pages:1851-1872

More Publications