Imperial College London

ProfessorDudleyPennell

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8810d.pennell

 
 
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Location

 

CMR UnitRoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

898 results found

Carpenter J-P, He T, Kirk P, Roughton M, Anderson LJ, de Noronha SV, Baksi AJ, Sheppard MN, Porter JB, Walker JM, Wood JC, Forni G, Catani G, Matta G, Fucharoen S, Fleming A, House M, Black G, Firmin DN, St Pierre TG, Pennell DJet al., 2014, Calibration of myocardial T2 and T1 against iron concentration, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 16, ISSN: 1097-6647

Journal article

Nielles-Vallespin S, Mekkaoui C, Gatehouse P, Reese TG, Keegan J, Ferreira PF, Collins S, Speier P, Feiweier T, de Silva R, Jackowski MP, Pennell DJ, Sosnovik DE, Firmin Det al., 2014, In Vivo Diffusion Tensor MRI of the Human Heart: Reproducibility of Breath-Hold and Navigator Based Approaches (vol 70, pg 454, 2013), MAGNETIC RESONANCE IN MEDICINE, Vol: 72, Pages: 599-599, ISSN: 0740-3194

Journal article

Dawson DK, McLernon DJ, Raj VJ, Maceira AM, Prasad S, Frenneaux MP, Pennell DJ, Kilner PJet al., 2014, Cardiovascular Magnetic Resonance Determinants of Left Ventricular Noncompaction, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 114, Pages: 456-462, ISSN: 0002-9149

Journal article

Ismail TF, Jabbour A, Gulati A, Mallorie A, Raza S, Cowling TE, Das B, Khwaja J, Alpendurada FD, Wage R, Roughton M, McKenna WJ, Moon JC, Varnava A, Shakespeare C, Cowie MR, Cook SA, Elliott P, O'Hanlon R, Pennell DJ, Prasad SKet al., 2014, Role of Late Gadolinium Enhancement Cardiovascular Magnetic Resonance in the Risk Stratification of Hypertrophic Cardiomyopathy, Heart

Journal article

Feng Y, He T, Feng M, Carpenter J-P, Greiser A, Xin X, Chen W, Pennell DJ, Yang G-Z, Firmin DNet al., 2014, Improved Pixel-by-Pixel MRI R2*Relaxometry by Nonlocal Means, MAGNETIC RESONANCE IN MEDICINE, Vol: 72, Pages: 260-268, ISSN: 0740-3194

Journal article

Garbowski MW, Carpenter J-P, Smith G, Roughton M, Alam MH, He T, Pennell DJ, Porter JBet al., 2014, Biopsy-based calibration of T2*magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 16, ISSN: 1097-6647

Journal article

Vassiliou V, Chin C, Perperoglou A, Tse G, Ali A, Raphael C, Jabbour A, Newby D, Pennell D, Dweck M, Prasad Set al., 2014, EJECTION FRACTION BY CARDIOVASCULAR MAGNETIC RESONANCE PREDICTS ADVERSE OUTCOMES POST AORTIC VALVE REPLACEMENT, HEART, Vol: 100, Pages: A53-A54, ISSN: 1355-6037

Journal article

Ripley DP, Saha A, Teis A, Uddin A, Bijsterveld P, Kidambi A, McDiarmid AK, Sivananthan M, Plein S, Pennell DJ, Greenwood JPet al., 2014, The distribution and prognosis of anomalous coronary arteries identified by cardiovascular magnetic resonance: 15 year experience from two tertiary centres, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 16, ISSN: 1097-6647

Journal article

Maceira AM, Ripoll C, Cosin-Sales J, Igual B, Gavilan M, Salazar J, Belloch V, Pennell DJet al., 2014, Long term effects of cocaine on the heart assessed by cardiovascular magnetic resonance at 3T, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 16, ISSN: 1097-6647

Journal article

Vera J, Rose K, Banya W, Drivas P, Keenan N, Pennell D, Winston Aet al., 2014, Evidence of premature atherosclerosis in HIV-infected individuals with low cardiovascular disease risk factors, HIV MEDICINE, Vol: 15, Pages: 73-74, ISSN: 1464-2662

Journal article

Petryka J, Quyam S, Smith B, Raphael C, Cowley B, Seale AN, Pennell D, Daubeney P, Prasad Set al., 2014, PROGNOSTIC SIGNIFICANCE OF CARDIOVASCULAR MAGNETIC RESONANCE FEATURE TRACKING DERIVED CIRCUMFERENTIAL STRAIN IN CHILDREN UNDERGOING FAMILY SCREENING AND PAEDIATRIC PATIENTS WITH SUSPECTED CARDIOMYOPATHY, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: A1038-A1038, ISSN: 0735-1097

Journal article

Vassiliou V, Raphael C, Ali A, Perperoglou A, Chin C, Nyktari E, Alpendurada F, Jabbour A, Baksi J, Murigu T, Joshi S, Wage R, Kilner P, Mohiaddin R, Newby D, Pennell D, Dweck M, Prasad Set al., 2014, MIDWALL FIBROSIS AND LONG-TERM OUTCOME IN PATIENTS WITH AORTIC STENOSIS, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: A1199-A1199, ISSN: 0735-1097

Journal article

Petryka J, Raphael C, Quyam S, Smith B, Cowley B, Seale AN, Pennell D, Daubeney P, Prasad Set al., 2014, THE PROGNOSTIC UTILITY OF MYOCARDIAL FIBROSIS IN PEDIATRIC CARDIOMYOPATHY SERVICE, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: A1040-A1040, ISSN: 0735-1097

Journal article

Pennell DJ, Porter JB, Piga A, Lai Y, El-Beshlawy A, Belhoul KM, Elalfy M, Yesilipek A, Kilinc Y, Lawniczek T, Habr D, Weisskopf M, Zhang Y, Aydinok Yet al., 2014, A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in beta-thalassemia major (CORDELIA), BLOOD, Vol: 123, Pages: 1447-1454, ISSN: 0006-4971

Journal article

El Beshlawy A, El Tagui M, Hamdy M, El Ghamrawy M, Azim KA, Salem D, Said F, Samir A, St Pierre T, Pennell DJet al., 2014, Low prevalence of cardiac siderosis in heavily iron loaded Egyptian thalassemia major patients, ANNALS OF HEMATOLOGY, Vol: 93, Pages: 375-379, ISSN: 0939-5555

Journal article

Petryka J, Baksi AJ, Prasad SK, Pennell DJ, Kilner PJet al., 2014, Prevalence of Inferobasal Myocardial Crypts Among Patients Referred for Cardiovascular Magnetic Resonance, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 7, Pages: 259-264, ISSN: 1941-9651

Journal article

Baksi AJ, Pennell DJ, 2014, T2* imaging of the heart: methods, applications, and outcomes., Top Magn Reson Imaging, Vol: 23, Pages: 13-20

This review describes and discusses the rationale, technique, applications, and impact of cardiovascular magnetic resonance (CMR) T2* imaging, principally in the assessment of iron loading within the heart, and highlights how this robust imaging strategy has transformed disease outcome.Until recently, no simple noninvasive measurement was available to reliably indicate severe cardiac iron loading before the development of overt cardiac dysfunction or heart failure. Consequently, the majority of patients with transfusion-dependent anemias, such as β-thalassemia major, died prematurely of cardiovascular complications of severe iron overload.The magnetic properties of particulate iron disrupt magnetic field homogeneity in the CMR environment and consequently influence the CMR parameter T2*, which describes signal decay relating to both field inhomogeneity and loss of spin coherence. There is a direct relationship between T2* and myocardial iron concentration, enabling this to be used to identify and quantify myocardial iron load. Single breath-hold gradient-echo sequences in which a single midventricular short-axis myocardial slice is acquired at multiple echo times enables a myocardial T2* value to be measured from the rate of exponential decay. The application of T2* CMR to assessing cardiac iron loading is rapid, reproducible, extensively validated, and now widely performed. Data have highlighted the profound predictive power of this imaging technique and moreover its ability to inform management strategies such that, over a relatively short duration, outcome has been dramatically improved, and the disease course in β-thalassemia major transformed.

Journal article

Babu-Narayan SV, Diller G-P, Gheta RR, Bastin AJ, Karonis T, Li W, Pennell DJ, Uemura H, Sethia B, Gatzoulis MA, Shore DFet al., 2014, Clinical Outcomes of Surgical Pulmonary Valve Replacement After Repair of Tetralogy of Fallot and Potential Prognostic Value of Preoperative Cardiopulmonary Exercise Testing, CIRCULATION, Vol: 129, Pages: 18-27, ISSN: 0009-7322

Journal article

Tunnicliffe EM, Scott AD, Ferreira P, Ariga R, McGill L-A, Nielles-Vallespin S, Neubauer S, Pennell DJ, Robson MD, Firmin DNet al., 2014, Intercentre reproducibility of cardiac apparent diffusion coefficient and fractional anisotropy in healthy volunteers, Journal of Cardiovascular Magnetic Resonance, Vol: 16, Pages: 31-31

Journal article

Khan TZ, Pottle A, Pennell DJ, Barbir MSet al., 2014, The expanding role of lipoprotein apheresis in the treatment of raised lipoprotein(a) in ischaemic heart disease and refractory angina., Glob Cardiol Sci Pract, Vol: 2014, Pages: 3-12, ISSN: 2305-7823

It is increasingly recognised that lipoprotein(a) [Lp(a)], an inherited, genetically-determined form of LDL-cholesterol, is an independent cardiovascular risk factor and predictor of adverse cardiovascular outcomes. Lp(a) is felt to increase cardiovascular risk via its pro-thrombotic effect and by enhancing intimal lipoprotein deposition. Lipoprotein apheresis is currently the most effective treatment for raised Lp(a). There is a growing body of evidence suggesting that aggressively lowering raised Lp(a) may improve cardiovascular and clinical outcomes, although much more research is required in this field. Angina which is refractory to conventional medical therapy and revascularisation, is extremely challenging to manage. Treatment options for such patients remain very limited. We describe the case of a patient with refractory angina and raised lipoprotein(a) in whom aggressive reduction of Lp(a) with lipoprotein apheresis successfully ameliorated the progression of coronary stenosis and provided effective and durable relief of angina symptoms. In our centre, we are currently conducting a prospective, randomised controlled cross-over study of patients with refractory angina and raised Lp(a), randomised to undergoing lipoprotein apheresis or 'sham' apheresis with assessment of myocardial perfusion, carotid atherosclerosis, endothelial vascular function, thrombogenesis, oxidised phospholipids and their antibodies, exercise capacity, angina symptoms and quality of life at the beginning and end of treatment.

Journal article

Ismail TF, Hsu L-Y, Greve AM, Gonçalves C, Jabbour A, Gulati A, Hewins B, Mistry N, Wage R, Roughton M, otherset al., 2014, Coronary microvascular ischemia in hypertrophic cardiomyopathy-a pixel-wise quantitative cardiovascular magnetic resonance perfusion study, Journal of Cardiovascular Magnetic Resonance, Vol: 16, Pages: 49-49

Journal article

Feng Y, He T, Gatehouse PD, Li X, Harith Alam M, Pennell DJ, Chen W, Firmin DNet al., 2013, Improved MRI R-2* Relaxometry of Iron-Loaded Liver with Noise Correction, MAGNETIC RESONANCE IN MEDICINE, Vol: 70, Pages: 1765-1774, ISSN: 0740-3194

Journal article

McGill L-A, Pennell DJ, 2013, Emerging roles for cardiovascular magnetic resonance., Clin Med (Lond), Vol: 13 Suppl 6, Pages: s3-s8

Cardiovascular magnetic resonance (CMR) is a noninvasive imaging tool with high spatial resolution in the absence of ionising radiation. CMR imaging is routine in the functional assessment of coronary lesions and is widely held as the gold standard in myocardial viability imaging. Its unique tissue characterisation capabilities have revolutionised the assessment of the cardiomyopathies and it is the investigation of choice for cardiovascular surveillance imaging. To date its greatest success has been in the management of thalassaemia major, where the ability to detect myocardial iron loading has significantly improved patient survival. In the near future, CMR fibrosis imaging may serve as a risk stratification tool for the cardiomyopathies; and the ability to assess interstitial fibrosis may advance this role into other disease processes. Novel methods of tissue characterisation and emerging technical advances present new avenues for this modality, securing its place as the noninvasive imaging tool of the future.

Journal article

Shiina Y, Niwa K, Li W, Rydman R, Uemura H, Pennell D, Kilner P, Gatzoulis MA, Babu-Narayan Set al., 2013, Non-invasive Predictors of Cardiac Outcomes in Adults With Ebstein Anomaly, Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322

Conference paper

Baksi AJ, Pennell DJ, 2013, T1 Mapping in Heart Failure From Technique to Prognosis, Toward Altering Outcome, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 6, Pages: E58-E60, ISSN: 1941-9651

Journal article

Bonello B, Kempny A, Uebing A, Li W, Kilner PJ, Diller G-P, Pennell DJ, Shore DF, Ernst S, Gatzoulis MA, Babu-Narayan SVet al., 2013, Right atrial area and right ventricular outflow tract akinetic length predict sustained tachyarrhythmia in repaired tetralogy of Fallot, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 3280-3286, ISSN: 0167-5273

Journal article

Deac M, Alpendurada F, Fanaie F, Vimal R, Carpenter J-P, Dawson A, Miller C, Roussin I, di Pietro E, Ismail TF, Roughton M, Wong J, Dawson D, Till JA, Sheppard MN, Mohiaddin RH, Kilner PJ, Pennell DJ, Prasad SKet al., 2013, Prognostic value of cardiovascular magnetic resonance in patients with suspected arrhythmogenic right ventricular cardiomyopathy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 3514-3521, ISSN: 0167-5273

Journal article

Gulati A, Ismail TF, Jabbour A, Alpendurada F, Guha K, Ismail NA, Raza S, Khwaja J, Brown TDH, Morarji K, Liodakis E, Roughton M, Wage R, Pakrashi TC, Sharma R, Carpenter J-P, Cook SA, Cowie MR, Assomull RG, Pennell DJ, Prasad SKet al., 2013, The Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Nonischemic Dilated Cardiomyopathy, CIRCULATION, Vol: 128, Pages: 1623-1633, ISSN: 0009-7322

Journal article

Pennell DJ, Baksi AJ, Carpenter JP, Firmin DN, Kilner PJ, Mohiaddin RH, Prasad SKet al., 2013, Review of Journal of Cardiovascular Magnetic Resonance 2012, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 15, ISSN: 1097-6647

Journal article

Feng Y, He T, Carpenter J-P, Jabbour A, Alam MH, Gatehouse PD, Greiser A, Messroghli D, Firmin DN, Pennell DJet al., 2013, In vivo comparison of myocardial T1 with T2 and T2*in thalassaemia major, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 38, Pages: 588-593, ISSN: 1053-1807

Journal article

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