Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology



+44 (0)20 7351 8810d.pennell




CMR UnitRoyal BromptonRoyal Brompton Campus






BibTex format

author = {Tayal, U and Wage, R and Ferreira, P and Nielles-Vallespin, S and Epstein, F and Auger, D and Zhong, X and Pennell, D and Firmin, D and Scott, A and Prasad, S},
doi = {10.1007/s10334-019-00735-5},
journal = {Magnetic Resonance Materials in Physics, Biology and Medicine},
pages = {317--329},
title = {The feasibility of a novel limited field of view spiral cine DENSE sequence to assess myocardial strain in dilated cardiomyopathy},
url = {},
volume = {32},
year = {2019}

RIS format (EndNote, RefMan)

AB - ObjectiveDevelop an accelerated cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR) sequence to enable clinically feasible myocardial strain evaluation in patients with dilated cardiomyopathy (DCM).Materials and methodsA spiral cine DENSE sequence was modified by limiting the field of view in two dimensions using in-plane slice-selective pulses in the stimulated echo. This reduced breath hold duration from 20RR to 14RR intervals. Following phantom and pilot studies, the feasibility of the sequence to assess peak radial, circumferential, and longitudinal strain was tested in control subjects (n = 18) and then applied in DCM patients (n = 29).ResultsDENSE acquisition was possible in all participants. Elements of the data were not analysable in 1 control (6%) and 4 DCM r(14%) subjects due to off-resonance or susceptibility artefacts and low signal-to-noise ratio. Peak radial, circumferential, short-axis contour strain and longitudinal strain was reduced in DCM patients (p < 0.001 vs. controls) and strain measurements correlated with left ventricular ejection fraction (with circumferential strain r = − 0.79, p < 0.0001; with vertical long-axis strain r = − 0.76, p < 0.0001). All strain measurements had good inter-observer agreement (ICC > 0.80), except peak radial strain.DiscussionWe demonstrate the feasibility of CMR strain assessment in healthy controls and DCM patients using an accelerated cine DENSE technique. This may facilitate integration of strain assessment into routine CMR studies.
AU - Tayal,U
AU - Wage,R
AU - Ferreira,P
AU - Nielles-Vallespin,S
AU - Epstein,F
AU - Auger,D
AU - Zhong,X
AU - Pennell,D
AU - Firmin,D
AU - Scott,A
AU - Prasad,S
DO - 10.1007/s10334-019-00735-5
EP - 329
PY - 2019///
SN - 0968-5243
SP - 317
TI - The feasibility of a novel limited field of view spiral cine DENSE sequence to assess myocardial strain in dilated cardiomyopathy
T2 - Magnetic Resonance Materials in Physics, Biology and Medicine
UR -
UR -
UR -
VL - 32
ER -