Imperial College London

ProfessorDudleyPennell

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8810d.pennell

 
 
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Location

 

CMR UnitRoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Khalique:2019:10.1007/s10334-019-00799-3,
author = {Khalique, Z and Scott, AD and Ferreira, PF and Nielles-Vallespin, S and Firmin, DN and Pennell, DJ},
doi = {10.1007/s10334-019-00799-3},
journal = {Magnetic Resonance Materials in Physics, Biology and Medicine},
pages = {331--342},
title = {Diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy: a comparison of motion-compensated spin echo and stimulated echo techniques},
url = {http://dx.doi.org/10.1007/s10334-019-00799-3},
volume = {33},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - ObjectivesDiffusion tensor cardiovascular magnetic resonance (DT-CMR) interrogates myocardial microstructure. Two frequently used in vivo DT-CMR techniques are motion-compensated spin echo (M2-SE) and stimulated echo acquisition mode (STEAM). Whilst M2-SE is strain-insensitive and signal to noise ratio efficient, STEAM has a longer diffusion time and motion compensation is unnecessary. Here we compare STEAM and M2-SE DT-CMR in patients.Materials and methodsBiphasic DT-CMR using STEAM and M2-SE, late gadolinium imaging and pre/post gadolinium T1-mapping were performed in a mid-ventricular short-axis slice, in ten hypertrophic cardiomyopathy (HCM) patients at 3 T.ResultsAdequate quality data were obtained from all STEAM, but only 7/10 (systole) and 4/10 (diastole) M2-SE acquisitions. Compared with STEAM, M2-SE yielded higher systolic mean diffusivity (MD) (p = 0.02) and lower fractional anisotropy (FA) (p = 0.02, systole). Compared with segments with neither hypertrophy nor late gadolinium, segments with both had lower systolic FA using M2-SE (p = 0.02) and trend toward higher MD (p = 0.1). The negative correlation between FA and extracellular volume fraction was stronger with STEAM than M2-SE (r2 = 0.29, p < 0.001 STEAM vs. r2 = 0.10, p = 0.003 M2-SE).DiscussionIn HCM, only STEAM reliably assesses biphasic myocardial microstructure. Higher MD and lower FA from M2-SE reflect the shorter diffusion times. Further work will relate DT-CMR parameters and microstructural changes in disease.
AU - Khalique,Z
AU - Scott,AD
AU - Ferreira,PF
AU - Nielles-Vallespin,S
AU - Firmin,DN
AU - Pennell,DJ
DO - 10.1007/s10334-019-00799-3
EP - 342
PY - 2019///
SN - 0968-5243
SP - 331
TI - Diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy: a comparison of motion-compensated spin echo and stimulated echo techniques
T2 - Magnetic Resonance Materials in Physics, Biology and Medicine
UR - http://dx.doi.org/10.1007/s10334-019-00799-3
UR - https://link.springer.com/article/10.1007%2Fs10334-019-00799-3
UR - http://hdl.handle.net/10044/1/75322
VL - 33
ER -