Publications
1024 results found
Bunce NH, Pennell DJ, 2001, Magnetic resonance of coronary arteries, EUROPEAN RADIOLOGY, Vol: 11, Pages: 721-731, ISSN: 0938-7994
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- Citations: 11
Bunce NH, Mohiaddin RH, Dahdal MD, et al., 2000, Contrast-enhanced magnetic resonance angiogram of coronary artery bypass graft aneurysm, CIRCULATION, Vol: 102, Pages: 3148-3148, ISSN: 0009-7322
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- Citations: 2
Masood S, Yang G, Pennell D, et al., 2000, Investigating Intrinsic Myocardial Mechanics - the role of MR tagging, velocity phase mapping and diffusion imaging, Journal of Magnetic Resonance Imaging, Vol: 12, Pages: 873-883
Anderson L, Porter JB, Wonke B, et al., 2000, Relationship of myocardial iron overload to right and left ventricular function in homozygous β-thalassemia., BLOOD, Vol: 96, Pages: 605A-+, ISSN: 0006-4971
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- Citations: 3
Anderson L, Porter JB, Wonke B, et al., 2000, Cardiac iron deposition is not predicted by conventional markers of iron overload in homozygous β-thalassaemia., BLOOD, Vol: 96, Pages: 606A-+, ISSN: 0006-4971
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- Citations: 4
Carr-White GS, Routledge T, Glennen S, et al., 2000, Incidence, location and significance of pulmonary homograft stenosis after the Ross operation: An echocardiographic and MRI study, CIRCULATION, Vol: 102, Pages: 372-372, ISSN: 0009-7322
Anderson LJ, Holden S, Davis BA, et al., 2000, A novel method of cardiac iron measurement using magnetic resonance T2*imaging in thalassemia: Validation and clinical application, CIRCULATION, Vol: 102, Pages: 403-403, ISSN: 0009-7322
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- Citations: 1
Panting JR, Gatehouse PD, Burger P, et al., 2000, Abnormally heterogeneous myocardial perfusion in syndrome X detected by first-pass magnetic resonance imaging., CIRCULATION, Vol: 102, Pages: 686-686, ISSN: 0009-7322
Rajappan K, Rimoldi OE, Ariff B, et al., 2000, The impairment of coronary vasodilator reserve is related to the severity of aortic stenosis, CIRCULATION, Vol: 102, Pages: 785-785, ISSN: 0009-7322
Rajappan K, Bellenger NG, Anderson L, et al., 2000, The role of cardiovascular magnetic resonance in heart failure, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 2, Pages: 241-252, ISSN: 1388-9842
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- Citations: 43
Bellenger NG, Burgess MI, Ray SG, et al., 2000, Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance - Are they interchangeable?, EUROPEAN HEART JOURNAL, Vol: 21, Pages: 1387-1396, ISSN: 0195-668X
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- Citations: 721
Bellenger NG, Grothues F, Smith GC, et al., 2000, Quantification of right and left ventricular function by cardiovascular magnetic resonance, HERZ, Vol: 25, Pages: 392-399, ISSN: 0340-9937
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- Citations: 54
Sorensen M, Ong P, Webb C, et al., 2000, Measurement of endothelium-dependent and endothelium-independent vascular function by cardiovascular magnetic resonance, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 525, Pages: 11P-11P, ISSN: 0022-3751
Bunce N, Grothues F, Panting J, et al., 2000, Non invasive assessment of patients with angina by magnetic resonance coronary angiography and perfusion, Heart, Vol: 83, ISSN: 1355-6037
The current "gold-standard" for the diagnosis of coronary artery disease is invasive cardiac catheterisation. Magnetic resonance coronary angiography (MRCA) can non-invasively assess coronary anatomy. Gadolinium MRI can also assess myocardial perfusion. The purpose of this study was to determine if a combined approach in one scan could be used to assess coronary artery disease in patients on the routine waiting list for cardiac catheterisation. MR scanning was performed in 16 patients (3 female, 13 male, mean age 56 years) with angina prior to coronary angiography. Using a Picker 1.5T magnet, coronary artery anatomy was studied using a 3 dimensional MRCA HOPE (Hybrid Ordered Phase Encoding) FLASH (Fast Low Angle Shot) technique. Eight 2.5mm slices were imaged in a 3D slab positioned in a transverse plane at the origin of the left main stem, with a second oblique slab to cover the right coronary artery. Cardiac motion was limited by ECG-gating at mid-diastole. Respiratory motion was suppressed by using navigator echoes through the right hemi-diaphragm and by respiratory reordering of the image data. Myocardial perfusion was performed at rest and during adenosine stress at 140μg/kg/min, using a first pass Gadolinium DTPA bolus administered by a power injector. All MR studies were completed in less than 1 hour. Cardiac catheterisation was performed in the standard manner and assessed for the presence of significant coronary stenoses (>50% diameter reduction). CMR images were visually assessed for the presence of coronary stenoses and for myocardial perfusion abnormalities. On X-ray angiography 9/16 patients had significant stenoses, all of which had abnormal MRCA and 5 of which had abnormal MR perfusion. Of the 7 patients with normal X-ray angiography, 6 had normal MRCA and 6 had normal MR perfusion. This combined approach is feasible, time effective, has the potential to reduce costs and would be useful for planning coronary intervention, by being able
Pennell DJ, Ray S, Webster J, et al., 2000, The christmas study: Incidence of hibernation and ischemia in heart failure, Heart, Vol: 83, ISSN: 1355-6037
The CHRISTMAS (Carvedilol Hibernation and Reversible Ischaemia Trial: Marker of Success) study investigates whether the presence of viable but dysfunctional myocardium is an important determinant of the improvement in ventricular function observed during treatment with Carvedilol of patients who have chronic heart failure (CHF) and ischemic heart disease (IHD) 400 such patients will be randomised to Carvedilol or placebo for 6 months. To date, 303 patients have been screened and 251 patients randomised into the study. Interim data on baseline characteristics are available on 159 patients. Viable but dysfunctional myocardium was defined as a mismatch between regional wall motion (echo -severe hypokinesia or worse), and nitrate enhanced resting MIBI uptake (>60% = viable) using a 9 segment model, and blind assessment by separate core labs. There were 138 (87%) males, mean age of 63 years, and mean ejection fraction of 28%. There was no difference in mean ejection fraction between the hibernating and non-hibernating groups (27.8% vs 28.7%, p=ns). The NYHA class was 13% class I, 62% class II, and 25% class 3. 57% of the patients had hibernation with a mean of 2.5 (range 1-6) segments, equivalent to 28% of the myocardium. There was no significant relation between the number of hibernating segments and the baseline ejection fraction (p=ns). Stress MIBI imaging showed that 55% of patients with hibernation had reversible defects suggesting ischemia (>10% segmental decrement in uptake) affecting an average of 1.4 (range 0-7) segments, compared with 55% ischaemic (p=ns) with 1.0 segments (range 0-5, p=ns) in the non-hibernating group. This large prospective study suggests that hibernation (57%) and stress induced ischemia (55%) are common in patients with CHF due to IHD and are therefore important potential targets for therapy in CHF, which might be addressed by beta-blockade.
Bellenger NG, Marcus NJ, Davies C, et al., 2000, Left ventricular function and mass after orthotopic heart transplantation: A comparison of cardiovascular magnetic resonance with echocardiography, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 19, Pages: 444-452, ISSN: 1053-2498
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- Citations: 55
Stables RH, Mohiaddin R, Panting J, et al., 2000, Images in cardiovascular medicine. Exclusion of an aneurysmal segment of the thoracic aorta with covered stents., Circulation, Vol: 101, Pages: 1888-1889
Taylor AM, Thorne SA, Rubens MB, et al., 2000, Coronary artery imaging in grown up congenital heart disease - Complementary role of magnetic resonance and X-ray coronary angiography, CIRCULATION, Vol: 101, Pages: 1670-1678, ISSN: 0009-7322
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- Citations: 124
Bellenger NG, Gatehouse PD, Rajappan K, et al., 2000, Left ventricular quantification in heart failure by cardiovascular MR using prospective respiratory navigator gating: Comparison with breath-hold acquisition, Journal of Magnetic Resonance Imaging, Vol: 11, Pages: 411-411, ISSN: 1053-1807
Bellenger NG, Gatehouse PD, Rajappan K, et al., 2000, Left ventricular quantification in heart failure by cardiovascular MR using prospective respiratory navigator gating: Comparison with breath-hold acquisition, JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 11, Pages: 411-417, ISSN: 1053-1807
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- Citations: 25
Taylor AM, Keegan J, Jhooti P, et al., 2000, A comparison between segmented k-space FLASH and interleaved spiral MR coronary angiography sequences, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 11, Pages: 394-400, ISSN: 1053-1807
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- Citations: 12
Pennell DJ, Ray SG, Davies G, et al., 2000, The Carvedilol Hibernation Reversible Ischaemia Trial, Marker of Success (CHRISTMAS) study - Methodology of a randomised, placebo controlled, multicentre study of carvedilol in hibernation and heart failure, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 72, Pages: 265-274, ISSN: 0167-5273
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- Citations: 15
Bellenger NG, Burgess MI, Ray SG, et al., 2000, Comparison of left ventricular functional analysis in heart failure by echocardiography, radionuclide ventriculography and magnetic resonance; Implications for research and clinical practice, Publisher: ELSEVIER SCIENCE INC, Pages: 427A-427A, ISSN: 0735-1097
Bellenger NG, Davies LC, Francis JM, et al., 2000, Cardiovascular magnetic resonance only requires small sample sizes in the study of heart failure, Publisher: ELSEVIER SCIENCE INC, Pages: 427A-427A, ISSN: 0735-1097
Karwatowski SP, Chronos NA, Sinclaire H, et al., 2000, Effect of systemic sclerosis on left ventricular long-axis motion and left ventricular mass assessed by magnetic resonance, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 2, Pages: 109-117, ISSN: 1097-6647
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- Citations: 7
Stables RH, Mohiaddin R, Panting J, et al., 2000, Exclusion of an aneurysmal segment of the thoracic aorta with covered stents, Circulation, Vol: 101, Pages: 1888-1889
Myerson SG, Pennell DJ, 2000, Intercostal artery aneurysm postcoarctation repair diagnosed by magnetic resonance angiography, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 2, Pages: 137-138, ISSN: 1097-6647
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- Citations: 12
, 2000, Guidelines for credentialing in cardiovascular magnetic resonance (CMR). Society for Cardiovascular Magnetic Resonance (SCMR) Clinical Practice Committee., J Cardiovasc Magn Reson, Vol: 2, Pages: 233-234, ISSN: 1097-6647
Bellenger NG, Davies LC, Francis JM, et al., 2000, Reduction in sample size for studies of remodeling in heart failure by the use of cardiovascular magnetic resonance, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 2, Pages: 271-278, ISSN: 1097-6647
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- Citations: 508
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