Imperial College London
Alternate

ProfessorDudleyPennell

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7351 8810d.pennell

 
 
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Location

 

CMR UnitRoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lindsay:2016:10.1161/CIRCINTERVENTIONS.115.003486,
author = {Lindsay, AC and Harron, K and Jabbour, RJ and Kanyal, R and Snow, TM and Sawhney, P and Alpendurada, F and Roughton, M and Pennell, DJ and Duncan, A and Di, Mario C and Davies, SW and Mohiaddin, RH and Moat, NE},
doi = {10.1161/CIRCINTERVENTIONS.115.003486},
journal = {Circulation: Cardiovascular Interventions},
title = {Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Patients Undergoing Transcatheter Aortic Valve Implantation.},
url = {http://dx.doi.org/10.1161/CIRCINTERVENTIONS.115.003486},
volume = {9},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Cardiovascular magnetic resonance (CMR) can provide important structural information in patients undergoing transcatheter aortic valve implantation. Although CMR is considered the standard of reference for measuring ventricular volumes and mass, the relationship between CMR findings of right ventricular (RV) function and outcomes after transcatheter aortic valve implantation has not previously been reported. METHODS AND RESULTS: A total of 190 patients underwent 1.5 Tesla CMR before transcatheter aortic valve implantation. Steady-state free precession sequences were used for aortic valve planimetry and to assess ventricular volumes and mass. Semiautomated image analysis was performed by 2 specialist reviewers blinded to patient treatment. Patient follow-up was obtained from the Office of National Statistics mortality database. The median age was 81.0 (interquartile range, 74.9-85.5) years; 50.0% were women. Impaired RV function (RV ejection fraction ≤50%) was present in 45 (23.7%) patients. Patients with RV dysfunction had poorer left ventricular ejection fractions (42% versus 69%), higher indexed left ventricular end-systolic volumes (96 versus 40 mL), and greater indexed left ventricular mass (101 versus 85 g/m(2); P<0.01 for all) than those with normal RV function. Median follow-up was 850 days; 21 of 45 (46.7%) patients with RV dysfunction died, compared with 43 of 145 (29.7%) patients with normal RV function (P=0.035). After adjustment for significant baseline variables, both RV ejection fraction ≤50% (hazard ratio, 2.12; P=0.017) and indexed aortic valve area (hazard ratio, 4.16; P=0.025) were independently associated with survival. CONCLUSIONS: RV function, measured on preprocedural CMR, is an independent predictor of mortality after transcatheter aortic valve implantation. CMR assessment of RV function may be important in the risk stratification of patients undergoing transcatheter aortic valve implantation.
AU  - Lindsay,AC
AU  - Harron,K
AU  - Jabbour,RJ
AU  - Kanyal,R
AU  - Snow,TM
AU  - Sawhney,P
AU  - Alpendurada,F
AU  - Roughton,M
AU  - Pennell,DJ
AU  - Duncan,A
AU  - Di,Mario C
AU  - Davies,SW
AU  - Mohiaddin,RH
AU  - Moat,NE
DO  - 10.1161/CIRCINTERVENTIONS.115.003486
PY  - 2016///
SN  - 1941-7640
TI  - Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Patients Undergoing Transcatheter Aortic Valve Implantation.
T2  - Circulation: Cardiovascular Interventions
UR  - http://dx.doi.org/10.1161/CIRCINTERVENTIONS.115.003486
VL  - 9
ER  -
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