Summary
Biography
| Date | Role |
|---|---|
| 2012- | Reader in Particle Science |
| 2012- | Director of Development -Discovery Space |
| 2008-2011 | Director of Pilot Plant Project |
| 2003-2007 |
Director of External Relations
|
| 1994- | EPSRC Advanced Fellow, Chemical Engineering Department, Imperial College London. |
| 1991-1994 | Research Fellow, Chemical Engineering Department, Imperial College London. |
| 1986-1990 | PhD Chemical Engineering Department, Imperial College London - Thesis Title " Interfacial Phenomena in Aramid Composites". |
| 1983-1985 | Experimental; Officer, MRL, Australia |
| 1982-1983 | MSc.(Polymer Science) Lehigh University, USA |
| 1981-1982 | Experimental, Officer, MRL, Australia |
| 1977-1980 | B.Sc.(Hons.) Physical Chemistry, University of Melbourne |
research interests
My current research interests focus on the particulate materials and material surfaces and their role in product manufacture including both biological and non-biological materials. I have developed a number of novel and leading edge methods for determining a range of surface and bulk physicochemical properties of powders and particulate materials including mechanical, topographical, chromatographic and surface properties.
Recent studies have included studies of protein aggregation, protein crystallisation and freeze drying. The group has world leading expertise in gravimetric charactisation methods as well as inverse chromatographic methods, having pioneered many of these approaches. For example, the water sorption characterisation of many classes of materials, especially pharmaceuticals, biomataterials and biopharmaceutical is an area of significant interest. Current and new project areas include:
- Protein crystallisation using nanotemplates
- Surface energy mapping of complex organic powders
- Micromechanics of agglomerates and cellular entities
- Physical stability of bioformulations
- Second virial coefficents and protein-protein aggregation behaviour
- Freeze drying of therapeutics
- Surfaces and Particle Engineering Laboratory
- SMS - UK Surface Measurement Systems
Selected Publications
Journal Articles
Shah UV, Allenby MC, Williams DR, et al., 2012, Crystallization of Proteins at Ultralow Supersaturations Using Novel Three-Dimensional Nanotemplates, Crystal Growth & Design, Vol:12, ISSN:1528-7483, Pages:1772-1777
Ho R, Dilworth SE, Williams DR, et al., 2011, Role of Surface Chemistry and Energetics in High Shear Wet Granulation, Industrial & Engineering Chemistry Research, Vol:50, ISSN:0888-5885, Pages:9642-9649
Roberts MM, Heng JYY, Williams DR, 2010, Protein Crystallization by Forced Flow through Glass Capillaries: Enhanced Lysozyme Crystal Growth, Crystal Growth & Design, Vol:10, ISSN:1528-7483, Pages:1074-1083
Yla-Maihaniemi PP, Heng JYY, Thielmann F, et al., 2008, Inverse gas chromatographic method for measuring the dispersive surface energy distribution for particulates, Langmuir, Vol:24, ISSN:0743-7463, Pages:9551-9557