Imperial College London
Alternate

ProfessorDarylWilliams

Faculty of Engineering, Department of Chemical Engineering

Professor of Particle Science
 
 
 
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Contact

 

+44 (0)20 7594 5611d.r.williams Website

 
 
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Location

 

439ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Duralliu:2018:10.1016/j.ejpb.2018.02.003,
author = {Duralliu, A and Matejtschuk, P and Williams, DR},
doi = {10.1016/j.ejpb.2018.02.003},
journal = {European Journal of Pharmaceutics and Biopharmaceutics},
pages = {29--36},
title = {Humidity induced collapse in freeze dried cakes: a direct visualization study using DVS},
url = {http://dx.doi.org/10.1016/j.ejpb.2018.02.003},
volume = {127},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Maintaining low moisture content is seen as crucial to sustaining long term stability in freeze dried (FD) cakes as higher moisture could lead to cake collapse, degradation and loss in biological potency. Using a combination of gravimetric data and video images captured from a Dynamic Vapour Sorption instrument the onset humidity Collapse Point (RHcp), the humidity Onset Crystallisation (RHc) and Onset Glass Transition (RHg) points for a series of freeze dried cakes at 10, 25 and 40°C have been determined. The moisture sorption behavior with respect to cake collapse and other morphological phase transitions are reported for a two freeze drying excipients and one product formulation; sucrose, trehalose (both 5% w/w) and an influenza antigen (A/Wisconsin/15/2009 H3N2 NYMCX-183, formulated with 1.1% w/w sucrose). Stability maps for all three formulations tested were reported as a function of %RH and temperature using the methods described in this work, thus direct visualization of collapse behavior for any FD cake can now be standardized and routinely determined, facilitating the formulation of FD products with improved stability and storage performance.
AU  - Duralliu,A
AU  - Matejtschuk,P
AU  - Williams,DR
DO  - 10.1016/j.ejpb.2018.02.003
EP  - 36
PY  - 2018///
SN  - 0939-6411
SP  - 29
TI  - Humidity induced collapse in freeze dried cakes: a direct visualization study using DVS
T2  - European Journal of Pharmaceutics and Biopharmaceutics
UR  - http://dx.doi.org/10.1016/j.ejpb.2018.02.003
UR  - https://www.sciencedirect.com/science/article/pii/S0939641117313115
VL  - 127
ER  -
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