The microbes that live in our guts, together known as the gut microbiota, are essential for maintaining our health. Changes to the make-up and function of this microbiota have been associated with a wide range of important diseases including inflammatory bowel disease, colorectal cancer, diabetes and neurodevelopmental disorders.
Because of the intimate relationship they have with their surroundings, our microbes offer an exciting opportunity to better understand the gut and to diagnose, monitor and treat disease in the clinic.
The Riglar lab uses a combination of synthetic biology, imaging and sequencing based approaches to better understand the function of the gut and its microbiota during health and disease. We use this knowledge to develop innovative technologies, such as living engineered probiotics, to probe and control the gut environment.
We are always excited to hear from enthusiastic people who are interested in working with us. Please get in touch to discuss whether there are opportunities available.
et al., 2019, Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface., Msystems, Vol:4, ISSN:2379-5077
Riglar DT, Silver PA, 2018, Engineering bacteria for diagnostic and therapeutic applications, Nature Reviews Microbiology, Vol:16, ISSN:1740-1526, Pages:214-225
et al., 2017, Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation, Nature Biotechnology, Vol:35, ISSN:1087-0156, Pages:653-+
et al., 2016, Localization-based imaging of malarial antigens during red cell entry reaffirms role for AMA1 but not MTRAP in invasion, Journal of Cell Science, Vol:129, ISSN:1477-9137, Pages:228-242
et al., 2013, Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes, Nature Communications, Vol:4, ISSN:2041-1723
et al., 2011, Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte, Cell Host & Microbe, Vol:9, ISSN:1931-3128, Pages:9-20