Imperial College London
Alternate

ProfessorDanielRueckert

Faculty of Engineering, Department of Computing

Professor of Visual Information Processing
 
 
 
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Contact

 

+44 (0)20 7594 8333d.rueckert Website

 
 
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Location

 

568Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tournier:2019:10.1101/661348,
author = {Tournier, J-D and Christiaens, D and Hutter, J and Price, AN and Cordero-Grande, L and Hughes, E and Bastiani, M and Sotiropoulos, SN and Smith, SM and Rueckert, D and Counsell, SJ and Edwards, AD and Hajnal, JV},
doi = {10.1101/661348},
title = {A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging},
url = {http://dx.doi.org/10.1101/661348},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Diffusion MRI has the potential to provide important information about the connectivity and microstructure of the human brain during normal and abnormal development, non-invasively and in vivo. Recent developments in MRI hardware and reconstruction methods now permit the acquisition of large amounts of data within relatively short scan times. This makes it possible to acquire more informative multi-shell data, with diffusion-sensitisation applied along many directions over multiple <jats:italic>b</jats:italic>-value shells. Such schemes are characterised by the number of shells acquired, and the specific <jats:italic>b</jats:italic>-value and number of directions sampled for each shell. However, there is currently no clear consensus as to how to optimise these parameters. In this work, we propose a means of optimising multi-shell acquisition schemes by estimating the information content of the diffusion MRI signal, and optimising the acquisition parameters for sensitivity to the observed effects, in a manner agnostic to any particular diffusion analysis method that might subsequently be applied to the data. This method was used to design the acquisition scheme for the neonatal diffusion MRI sequence used in the developing Human Connectome Project, which aims to acquire high quality data and make it freely available to the research community. The final protocol selected by the algorithm, and currently in use within the dHCP, consists of <jats:italic>b =</jats:italic> 0, 400, 1000, 2600 s/mm<jats:sup>2</jats:sup> with 20, 64, 88 & 128 DW directions per shell respectively.</jats:p><jats:sec><jats:title>Highlights</jats:title><jats:list list-type="bullet"><jats:list-item><jats:p>A data driven method is presented to design multi-shell diffusion MRI acquisition schemes (<jats:italic>b</jats:italic&g
AU  - Tournier,J-D
AU  - Christiaens,D
AU  - Hutter,J
AU  - Price,AN
AU  - Cordero-Grande,L
AU  - Hughes,E
AU  - Bastiani,M
AU  - Sotiropoulos,SN
AU  - Smith,SM
AU  - Rueckert,D
AU  - Counsell,SJ
AU  - Edwards,AD
AU  - Hajnal,JV
DO  - 10.1101/661348
PY  - 2019///
TI  - A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging
UR  - http://dx.doi.org/10.1101/661348
ER  -
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