Imperial College London
Alternate

ProfessorDanielRueckert

Faculty of Engineering, Department of Computing

Professor of Visual Information Processing
 
 
 
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Contact

 

+44 (0)20 7594 8333d.rueckert Website

 
 
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Location

 

568Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Thanaj:2021:10.1101/2021.06.07.21257302,
author = {Thanaj, M and Mielke, J and McGurk, KA and Bai, W and Savioli, N and de, Marvao A and Meyer, HV and Zeng, L and Sohler, F and Wilkins, MR and Ware, JS and Bender, C and Rueckert, D and MacNamara, A and Freitag, DF and ORegan, DP},
doi = {10.1101/2021.06.07.21257302},
title = {Genetic and environmental determinants of diastolic heart function},
url = {http://dx.doi.org/10.1101/2021.06.07.21257302},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>ABSTRACT</jats:title><jats:p>Diastole is the sequence of physiological events that occur in the heart during ventricular filling and principally depends on myocardial relaxation and chamber stiffness. Abnormal diastolic function is related to many cardiovascular disease processes and is predictive of health outcomes, but its genetic architecture is largely unknown. Here, we use machine learning cardiac motion analysis to measure diastolic functional traits in 39,559 participants of UK Biobank and perform a genome-wide association study. We identified 9 significant, independent loci near genes that are associated with maintaining sarcomeric function under biomechanical stress and genes implicated in the development of cardiomyopathy. Age, sex and diabetes were independent predictors of diastolic function and we found a causal relationship between ventricular stiffness and heart failure. Our results provide novel insights into the genetic and environmental factors influencing diastolic function that are relevant for identifying causal relationships and tractable targets in heart failure.</jats:p>
AU  - Thanaj,M
AU  - Mielke,J
AU  - McGurk,KA
AU  - Bai,W
AU  - Savioli,N
AU  - de,Marvao A
AU  - Meyer,HV
AU  - Zeng,L
AU  - Sohler,F
AU  - Wilkins,MR
AU  - Ware,JS
AU  - Bender,C
AU  - Rueckert,D
AU  - MacNamara,A
AU  - Freitag,DF
AU  - ORegan,DP
DO  - 10.1101/2021.06.07.21257302
PY  - 2021///
TI  - Genetic and environmental determinants of diastolic heart function
UR  - http://dx.doi.org/10.1101/2021.06.07.21257302
ER  -
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