Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Clinical Senior Lecturer in Hepato-Biliary Surgery



+44 (0)20 3313 3941d.spalding




Hammersmith HospitalHammersmith Campus






Clinical Senior Lecturer and Honorary Consultant in Hepatobiliary and Pancreatic Surgery. Has a clinical interest in HPB Surgery with a specific focus on minimally invasive techniques, the use of radiofrequency energy as a resection tool, cholangiocarcinomas and neuroendocrine tumours.



  • BSc in Biochemistry, University of Southampton, 1985
  • MB ChB, University of Birmingham, 1989
  • FRCS (Eng), 1993
  • FRCS (Gen Surg), 2002
  • MD, University of London, 2006

 Research Interests

  • Molecular pathogenesis of cholangiocarcinomas to identify novel therapeutic targets.
  • Early detection of cholangiocarcinomas using novel biomarkers
  • Synthesis of novel molecular conjugates comprising chemotherapeutic agents and transporter molecules for targeted delivery to cholangiocarcinomas.
  • Stellate cancer-associated fibroblasts contribution to chemoresistance of pancreatic ductal adenocarcinoma.

Membership of Professional Bodies

  • Association of Surgeons of Great Britain and Ireland
  • Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland
  • Fellow of the Royal College of Surgeons of England
  • International Hepatopancreatobiliary Association
  • Royal Society of Medicine
  • British Medical Association

 Teaching Activities

Undergraduate Teaching

  • Module leader BSc in Surgery and Anaesthesia (Module 1: Regeneration, repair and cancer control).
  • BSc in Gastroenterology and Hepatology

  Postgraduate Teaching

  • MSc in Surgical Science
  • MSc in Surgical Technology

 Invited Teaching

  • Whipps Cross Higher Surgery Course

  Postgraduate Supervision

  • Supervising 2 PhD, 2 MSc and 1 MRes Projects  

 Editorial Boards  

  • Sub-editor of the Journal of HPB Surgery 



Spalding, D R C, Williamson, et al., 2007, Pancreatic cancer, Medicine

Reccia I, Kumar J, Kusano T, et al., 2018, Radiofrequency-assisted liver resection: Technique and results, Surgical Oncology, Vol:27, ISSN:0960-7404, Pages:415-420

Markar SR, Brodie B, Chin S-T, et al., 2018, Profile of exhaled-breath volatile organic compounds to diagnose pancreatic cancer., Br J Surg


McKay S, Pericleous S, Kent-Bramer J, et al., Surgical Management of Cholangiocarcinoma, 9th World Congress of the International Hepato-Pancreato-Biliary Association, Pages:1-468

McKay S, Unger K, Pericleous S, et al., Array comparative genomic hybridization identifies novel potential therapeutic targets for cholangiocarcinoma., 9th World Congress of the International Hepato-Pancreato-Biliary Association, Pages:1-468

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