Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Clinical Senior Lecturer in Hepato-Biliary Surgery



+44 (0)20 3313 3941d.spalding




Hammersmith HospitalHammersmith Campus






Clinical Senior Lecturer and Honorary Consultant in Hepatobiliary and Pancreatic Surgery. Has a clinical interest in HPB Surgery with a specific focus on minimally invasive techniques, the use of radiofrequency energy as a resection tool, cholangiocarcinomas and neuroendocrine tumours.



  • BSc in Biochemistry, University of Southampton, 1985
  • MB ChB, University of Birmingham, 1989
  • FRCS (Eng), 1993
  • FRCS (Gen Surg), 2002
  • MD, University of London, 2006

 Research Interests

  • Molecular pathogenesis of cholangiocarcinomas to identify novel therapeutic targets.
  • Early detection of cholangiocarcinomas using novel biomarkers
  • Synthesis of novel molecular conjugates comprising chemotherapeutic agents and transporter molecules for targeted delivery to cholangiocarcinomas.
  • Stellate cancer-associated fibroblasts contribution to chemoresistance of pancreatic ductal adenocarcinoma.

Membership of Professional Bodies

  • Association of Surgeons of Great Britain and Ireland
  • Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland
  • Fellow of the Royal College of Surgeons of England
  • International Hepatopancreatobiliary Association
  • Royal Society of Medicine
  • British Medical Association

 Teaching Activities

Undergraduate Teaching

  • Module leader BSc in Surgery and Anaesthesia (Module 1: Regeneration, repair and cancer control).
  • BSc in Gastroenterology and Hepatology

  Postgraduate Teaching

  • MSc in Surgical Science
  • MSc in Surgical Technology

 Invited Teaching

  • Whipps Cross Higher Surgery Course

  Postgraduate Supervision

  • Supervising 2 PhD, 2 MSc and 1 MRes Projects  

 Editorial Boards  

  • Sub-editor of the Journal of HPB Surgery 



Brodie BA, Marker SR, Romano A, et al., 2017, Non-invasive exhaled breath volatile organic compound analysis for the diagnosis of pancreatic cancer, British Journal of Surgery, Vol:104, ISSN:0007-1323, Pages:37-37

Khoo B, Boshier PR, Freethy A, et al., 2017, Redefining the stress cortisol response to surgery., Clin Endocrinol (oxf)

Reccia I, Kumar J, Akladios C, et al., 2017, Non-alcoholic fatty liver disease: A sign of systemic disease, Metabolism-clinical and Experimental, Vol:72, ISSN:0026-0495, Pages:94-108

Reccia I, Kumar J, Kusano T, et al., 2017, A systematic review on radiofrequency assisted laparoscopic liver resection: Challenges and window to excel, Surgical Oncology-oxford, Vol:26, ISSN:0960-7404, Pages:296-304

Yoon S, Huang K-W, Reebye V, et al., 2017, Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth, Molecular Therapy-nucleic Acids, Vol:6, ISSN:2162-2531, Pages:80-88

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