Publications
126 results found
Wadsworth CA, Dixon PH, Zabron AA, et al., 2011, COMMON GENETIC VARIATION IN NATURAL KILLER CELL RECEPTOR PROTEIN G2D DOES NOT MODIFY SUSCEPTIBILITY TO SPORADIC CHOLANGIOCARCINOMA, 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER, Pages: S108-S109, ISSN: 0168-8278
Wadsworth CA, Dixon PH, Zabron AA, et al., 2011, GENETIC VARIATION IN BILIARY TRANSPORTERS AS A SUSCEPTIBILITY FACTOR FOR CHOLANGIOCARCINOMA, 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER, Pages: S109-S109, ISSN: 0168-8278
Bong JJ, Wang J, Spalding DR, 2011, Pancreatobiliary and pancreatoduodenal fistulae in intraductal papillary mucinous neoplasm of the pancreas: Report of a case, SURGERY TODAY, Vol: 41, Pages: 281-284, ISSN: 0941-1291
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- Citations: 5
Bong JJ, Kumar R, Spalding D, 2011, A Novel Technique of Partial Splenectomy Using Radiofrequency Ablation, JOURNAL OF GASTROINTESTINAL SURGERY, Vol: 15, Pages: 371-372, ISSN: 1091-255X
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- Citations: 9
Wadsworth CA, Dixon PH, Wong JH, et al., 2011, Genetic Factors in the Pathogenesis of Cholangiocarcinoma, DIGESTIVE DISEASES, Vol: 29, Pages: 93-97, ISSN: 0257-2753
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- Citations: 26
Carroll RW, Martin JL, Tan T, et al., 2011, Primary Lymph Node Gastrinoma: A Genuine Entity? Two Case Reports and a Review of the Literature, 8th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocine Tumor Disease, Publisher: KARGER, Pages: 18-19, ISSN: 0028-3835
Sotiropoulos G, Li J, Al-Nahhas A, et al., 2011, The Impact of 68Ga-DOTATOC PET/CT on the Multimodal Management of Patients with Neuroendocrine Tumors, 8th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocine Tumor Disease, Publisher: KARGER, Pages: 45-45, ISSN: 0028-3835
McKay S, Unger K, Sriraksa R, et al., 2010, Differing copy number alteration profiles identified by array CGH in Thai IntrahepaticCholangiocarcinoma related to prognosis, The 61st Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2010
Purpose: The worldwide incidence of intrahepatic cholangiocarcinomahas vastly increased over the past three decades,and now represents the second most common primary liver cancer.Despite this increase in incidence mortality figures forcholangiocarcinoma remain dismal. We employed array comparativegenomic hybridization to identify copy number alterationsin cholangiocarcinoma with prognostic significance.Methods: DNA was extracted from 24 Thai cases of intrahepaticcholangiocarcinoma (ICC), and labelled using randomprimer labelling (Enzo Life Sciences CGH Labeling Kit). TumourDNA was labelled with Cy3 and sex-mismatched referenceDNA (pooled normal DNA, Promega) with Cy5 fluorescencedye and hybridised to 180K Agilent Oligonucleotide arrayCGH slides for 24 hours. Microarray slides were scanned at 3micron (Agilent), fluorescence intensities extracted using theFeature Extraction Software (Agilent) and subsequentlyanalysed within the statistical environment R using the CBSalgorithm for segmenation of profiles and the CGHcall packagefor calling of copy number gains and losses. Results: Analysisof the data revealed three distinct groups of copy number (CN)alterations related to overall survival. Groups were separatedinto poor (>4 weeks and <13 weeks, n=9), moderate (>14weeks and <57 weeks, n=7) and good (>58 weeks, n=8) survival.The good survival group demonstrated very few CN alterations.Gains at 1q and 11q, and losses at 1p and 2q werespecific to poor survival. Gains at 1p, 7p and 13p/q, andlosses at 11p, 12q and 15p were specific for moderate survival.Several CN alterations were demonstrated in the poorand moderate group, and not found in the good group, includinggain at 2q, and losses at 3p, 4p/q, 5q, 6q, 8p and18p/q. The two most charateristic alterations were gain at1q21.1-24.2 in poor suvivors (p value < 0.04 FDR < 0.11) andgain at 8q24.3 in good survivors (p value < 0.001 and FDR=0.024). Conclusion: Intrahepatic cholangiocarcinoma remainsa clin
Pericleous S, Biswas A, McKay S, et al., 2010, Chemotherapy for cholangiocarcinoma; the effect of dual versus monotherapy on multiple cell lines, The Association for Cancer Surgery Scientific Conference, Publisher: Elsevier, ISSN: 0748-7983
McKay S, Unger K, Sriraksa R, et al., 2010, Differing copy number alteration profiles identified by array CGH in Thai Intrahepatic Cholangiocarcinoma related to prognosis., London 4th Surgical Symposium
Gogalniceanu P, Purkayastha S, Spalding D, et al., 2010, Chyle leak following laparoscopic cholecystectomy: a rare complication., Ann R Coll Surg Engl, Vol: 92, Pages: W12-W14
Gallstone disease is a highly prevalent condition which is commonly and safely treated by laparoscopic cholecystectomy. We present the third reported case of chyle leakage following laparoscopic cholecystectomy in the setting of acute cholecystitis. The report reviews current literature on the prevalence, diagnosis and management of this condition.
Comninos AN, Badman M, Troke R, et al., 2010, An insulinoma in a patient with tuberous sclerosis: Association or coincidence?, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 14-14, ISSN: 0167-0115
Adjene A, Comninos A, Troke R, et al., 2010, The difficulties of managing an insulinoma in pregnancy, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 13-13, ISSN: 0167-0115
McKay S, Unger K, Pericleous S, et al., 2010, Array comparative genomic hybridization identifies novel potential therapeutic targets for cholangiocarcinoma., 9th World Congress of the International Hepato-Pancreato-Biliary Association, Pages: 1-468
McKay S, Pericleous S, Kent-Bramer J, et al., 2010, Surgical Management of Cholangiocarcinoma, 9th World Congress of the International Hepato-Pancreato-Biliary Association, Pages: 1-468
Pericleous S, McKay S, Mezes P, et al., 2010, Surgery for metastases to the pancreas., 9th World Congress of the International Hepato-Pancreato-Biliary Association, Pages: 1-468
Pericleous S, McKay SC, Mathieson W, et al., 2010, Array Comparative Hybridisation to Cholangiocarcinoma Cell Lines HuCC-T1 and SkChA-1., The Pathological Society Scientific Meeting
Bong JJ, Spalding D, 2010, Duodenal Duplication Cyst (DDC) Communicating with the Pancreatobiliary Duct-A Rare Cause of Recurrent Acute Pancreatitis in Adults, JOURNAL OF GASTROINTESTINAL SURGERY, Vol: 14, Pages: 199-202, ISSN: 1091-255X
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- Citations: 5
Mckay S, Unger K, Spalding D, et al., 2009, Novel potential therapeutic targets for cholangiocarcinoma identified by array comparative hybridization, Annual Meeting of the EORTC/NCI/ASCO on Molecular Markers in Cancer, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 24-24, ISSN: 1359-6349
Spalding DRC, Behranwala KA, Straker P, et al., 2009, Non-occlusive small bowel necrosis in association with feeding jejunostomy after elective upper gastrointestinal surgery, ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, Vol: 91, Pages: 477-482, ISSN: 0035-8843
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- Citations: 18
Narasimhaiah R, James E, Siegmueller C, et al., 2009, PRE-OPERATIVE C-REACTIVE PROTEIN (CRP) AS A PROGNOSTIC INDICATOR OF ONE YEAR MORTALITY FOLLOWING CURATIVE PANCREATECTOMY, 22nd Annual Congress of the European-Society-of-Intensive-Care-Medicine, Publisher: SPRINGER, Pages: 275-275, ISSN: 0342-4642
Gatenby P, Flook M, Spalding D, et al., 2009, Percutaneous transhepatic cholecystoduodenal stent for empyema of the gallbladder., Br J Radiol, Vol: 82, Pages: e108-e110
Acute cholecystitis is treated by antibiotics and cholecystectomy. When the gallbladder neck is obstructed in the presence of infection, preventing pus from draining via the cystic duct, an empyema of the gallbladder develops. Under these circumstances, treatment may be either cholecystectomy or, in the presence of significant comorbidity, by drainage via percutaneous cholecystostomy, followed at a later date by cholecystectomy. We present the case of a patient who presented acutely with an attack of cholecystitis and refused to undergo a cholecystectomy owing to previous respiratory arrest following general anaesthesia. She settled with intravenous antibiotic treatment and was discharged. However, she presented shortly afterwards with a further attack of cholecystitis that was refractory to intravenous antibiotics and so was treated initially with percutaneous drainage. This was subsequently replaced with interno-external drainage of the gallbladder (transpapillary cholecystoduodenal stent) with the use of a J-J ureteric stent, which was then fully internalised. She remained well following this procedure and was discharged home. The long-term patency of the stent is not known and we hope that no further intervention will be required, but if necessary the stent could be exchanged endoscopically, by a percutaneous route, or via a combined approach.
Pai M, Jiao LR, Khorsandi S, et al., 2008, Liver resection with bipolar radiofrequency device: Habib™ 4X, HPB, Vol: 10, Pages: 256-260, ISSN: 1365-182X
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- Citations: 48
Spalding, D R C, Williamson, et al., 2008, Peritonitis, British Journal of Hospital Medicine
El-Gendi AM, Khorsandi SE, Pai M, et al., 2008, Repeat hepatic resection using a radiofrequency-assisted technique, DIGESTIVE SURGERY, Vol: 25, Pages: 293-299, ISSN: 0253-4886
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- Citations: 6
Ayav A, Navarra G, Basaglia E, et al., 2007, Results of major hepatectomy without vascular clamping using radiofrequency-assisted technique compared with total vascular exclusion, HEPATO-GASTROENTEROLOGY, Vol: 54, Pages: 806-809, ISSN: 0172-6390
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- Citations: 2
Spalding, D R C, Isla A M, et al., 2007, Pancreas-sparing distal duodenectomy (PSDD) for infrapapillary neoplasms, Annals of The Royal College of Surgeons of England, Vol: 89, Pages: 130-135, ISSN: 0035-8843
Spalding, D R C, 2006, Pancreatic and periampullary cancers: treatment and outcome, British Journal of Hospital Medicine, Vol: 67, Pages: 14-20, ISSN: 1462-3935
Spalding, D R C, Williamson, et al., 2004, The Spleen, Clinical Surgery, Editors: Henry, Thompson, Publisher: Saunders
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