Imperial College London
Mr Duncan Spalding

MrDuncanSpalding

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Hepato-Biliary Surgery
 
 
 
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Contact

 

+44 (0)20 3313 3941d.spalding

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cheng:2015:10.1016/j.apsb.2015.02.003,
author = {Cheng, Z and Lv, Y and Pang, S and Bai, R and Wang, M and Lin, S and Xu, T and Spalding, D and Habib, N and Xu, R},
doi = {10.1016/j.apsb.2015.02.003},
journal = {Acta Pharmaceutica Sinica B},
pages = {194--200},
title = {Kallistatin, a new and reliable biomarker for the diagnosis of liver cirrhosis.},
url = {http://dx.doi.org/10.1016/j.apsb.2015.02.003},
volume = {5},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Kallistatin, which protects organs and cells against inflammation, fibrosis and oxidative stress, is mainly synthesized and secreted in liver. However, its relationship to human liver disease remains unclear. The purpose of this study was to explore the relationship between serum kallistatin and clinical evidence of both cirrhosis and hepatocellular carcinoma (HCC), and to determine if serum kallistatin levels could be used as a diagnostic indicator of hepatic health status, especially human liver cirrhosis (LC). Our cohort consisted of 115 patients with clinically proven liver fibrosis (LF), LC, or HCC by liver biopsies, and 31 healthy controls (CON). Serum kallistatin levels were quantified by ELISA. Results of the present study demonstrated that irrespective of the underlying etiology, serum kallistatin levels were significantly lower in the LF/LC group when compared with the CON group. A decrease in serum kallistatin levels appeared to reflect the extent of cirrhosis, with the lowest levels associated with higher grades of cirrhosis. Patients with LC had a noticeable correlation between serum kallistatin levels and other serum biochemical indicators. The area under the curve (AUC) for LC, viral liver cirrhosis (VLC) and alcoholic liver cirrhosis (ALC) was 0.845, 0.757 and 0.931, respectively. In conclusion, our findings demonstrated that kallistatin, a plasma protein produced by the liver, can be a useful and reliable diagnostic indicator of hepatic health status, especially for LC.
AU  - Cheng,Z
AU  - Lv,Y
AU  - Pang,S
AU  - Bai,R
AU  - Wang,M
AU  - Lin,S
AU  - Xu,T
AU  - Spalding,D
AU  - Habib,N
AU  - Xu,R
DO  - 10.1016/j.apsb.2015.02.003
EP  - 200
PY  - 2015///
SN  - 2211-3843
SP  - 194
TI  - Kallistatin, a new and reliable biomarker for the diagnosis of liver cirrhosis.
T2  - Acta Pharmaceutica Sinica B
UR  - http://dx.doi.org/10.1016/j.apsb.2015.02.003
UR  - http://hdl.handle.net/10044/1/27790
VL  - 5
ER  -
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