Imperial College London

DrDaphneStapels

Faculty of MedicineDepartment of Infectious Disease

Honorary Research Associate
 
 
 
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Contact

 

d.stapels

 
 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Summary

I am interested in the interplay between bacteria and their host. I investigate how non-growing, persister, Salmonella can survive inside macrophages for extended periods time. Moreover, I am studying how these bacteria can withstand both immune pressure and antibiotic treatment during infection. This research is carried out in the in the lab of Dr. Sophie Helaine.

LinkedIn profile

Selected Publications

Journal Articles

Stapels DAC, Hill PWS, Westermann AJ, et al., 2018, Salmonella persisters undermine host immune defenses during antibiotic treatment, Science, Vol:362, ISSN:0036-8075, Pages:1156-1160

Saliba A-E, Li L, Westermann AJ, et al., 2016, Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella, Nature Microbiology, Vol:2, ISSN:2058-5276

Stapels DAC, Kuipers A, von Köckritz-Blickwede M, et al., 2016, Staphylococcus aureus protects its immune-evasion proteins against degradation by neutrophil serine proteases., Cell Microbiol, Vol:18, Pages:536-545

Stapels DAC, Ramyar KX, Bischoff M, et al., 2014, Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors., Proc Natl Acad Sci U S A, Vol:111, Pages:13187-13192

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