Imperial College London
Alternate

Dr Dina Vlachou

Faculty of Natural Sciences, Department of Life Sciences

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 1267d.vlachou Website

 
 
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Location

 

612Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ukegbu:2019:10.1101/652115,
author = {Ukegbu, CV and Giorgalli, M and Tapanelli, S and Rona, LDP and Jaye, A and Wyer, C and Angrisano, F and Blagborough, AM and Christophides, GK and Vlachou, D},
doi = {10.1101/652115},
title = {<i>Plasmodium</i> PIMMS43 is required for ookinete evasion of the mosquito complement-like response and sporogonic development in the oocyst},
url = {http://dx.doi.org/10.1101/652115},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Malaria transmission requires <jats:italic>Plasmodium</jats:italic> parasites to successfully infect a female <jats:italic>Anopheles</jats:italic> mosquito, surviving a series of robust innate immune responses. Understanding how parasites evade these responses can highlight new ways to block malaria transmission. We show that ookinete and sporozoite surface protein PIMMS43 is required for <jats:italic>Plasmodium</jats:italic> ookinete evasion of the <jats:italic>Anopheles coluzzii</jats:italic> complement-like system and for sporogonic development in the oocyst. Disruption of <jats:italic>P. berghei</jats:italic> PIMMS43 triggers robust complement activation and ookinete elimination upon mosquito midgut traversal. Silencing the complement-like system restores ookinete-to-oocyst transition. Antibodies that bind PIMMS43 interfere with parasite immune evasion when ingested with the infectious blood meal and significantly reduce the prevalence and intensity of infection. PIMMS43 genetic structure across African <jats:italic>P. falciparum</jats:italic> populations indicates allelic adaptation to sympatric vector populations. These data significantly add to our understanding of mosquito-parasite interactions and identify PIMMS43 as a target of interventions aiming at malaria transmission blocking.</jats:p><jats:sec><jats:title>Author summary</jats:title><jats:p>Malaria is a devastating disease transmitted among humans through mosquito bites. Mosquito control has significantly reduced clinical malaria cases and deaths in the last decades. However, as mosquito resistance to insecticides is becoming widespread impacting on current control tools, such as insecticide impregnated bed nets and indoor spraying, new interventions are urgently needed, especially those that target disease transmission. Here, we characterize
AU  - Ukegbu,CV
AU  - Giorgalli,M
AU  - Tapanelli,S
AU  - Rona,LDP
AU  - Jaye,A
AU  - Wyer,C
AU  - Angrisano,F
AU  - Blagborough,AM
AU  - Christophides,GK
AU  - Vlachou,D
DO  - 10.1101/652115
PY  - 2019///
TI  - <i>Plasmodium</i> PIMMS43 is required for ookinete evasion of the mosquito complement-like response and sporogonic development in the oocyst
UR  - http://dx.doi.org/10.1101/652115
ER  -
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