Professor Dale Wigley and his team at the Imperial College London are finding out what happens when the DNA in a cell is damaged, and how the cell deals with it. If DNA damage is not repaired correctly, mistakes occur in important genes which can lead to cancer.
Professor Wigley studies bacteria grown in the lab to investigate DNA repair. Bacteria are a simple model system and easier to work with than human cells. Understanding the DNA repair processes in bacteria will help Professor Wigley and his team gain insight into the similar, more complex, processes at work in human cells.
Learning more about how cells repair damage to their DNA could lead to new ways to prevent or treat cancer in the future.
- 1985 - BSc (Hons) Biochemistry, University of York
- 1988 - PhD Biochemistry, University of Bristol
- 1988-1990,Temporary Lecturer, University of Leicester
- 1990-1992, SERC Advanced Fellow, University of York
- 1993-1997, Lecturer, University of Oxford
- 1997-2000, Reader, University of Oxford
- 2000 - 2010, Principal Scientist, Cancer Research UK
- 2010 - 2014, Professor and Head of Division, Institute Cancer Research
- 2014 - present, Professor, Section of Structural Biology, Department of Medicine, Imperial College London
et al., 2018, Structure and regulation of the human INO80-nucleosome complex, Nature, Vol:556, ISSN:0028-0836, Pages:391-+
et al., 2018, Cryo-EM structures of the human INO80 chromatin-remodeling complex, Nature Structural & Molecular Biology, Vol:25, ISSN:1545-9993, Pages:37-+
et al., 2017, Functional characterization and architecture of recombinant yeast SWR1 histone exchange complex, Nucleic Acids Research, Vol:45, ISSN:0305-1048, Pages:7249-7260
et al., 2017, Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding, Elife, Vol:6, ISSN:2050-084X
et al., 2017, The structure and function of an RNA polymerase interaction domain in the PcrA/UvrD helicase, Nucleic Acids Research, Vol:45, ISSN:0305-1048, Pages:3875-3887