Imperial College London

ProfessorDominicWithers

Faculty of MedicineInstitute of Clinical Sciences

Clinical Chair in Diabetes & Endocrinology
 
 
 
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Contact

 

d.withers

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

95 results found

Hine C, Kim H-J, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng S-Y, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JRet al., 2017, Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production, CELL METABOLISM, Vol: 25, Pages: 1320-+, ISSN: 1550-4131

JOURNAL ARTICLE

Selman C, Withers DJ, 2017, PHYSIOLOGY An atypical switch for metabolism and ageing, NATURE, Vol: 542, Pages: 299-300, ISSN: 0028-0836

JOURNAL ARTICLE

Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To WK, Dimond A, Sardini A, Webster Z, McGinty J, Paul EJ, Ungless MA, French PMW, Withers DJ, Uren A, Ferguson-Smith AC, Merkenschlager M, John RM, Fisher AGet al., 2017, Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults, CELL REPORTS, Vol: 18, Pages: 1090-1099, ISSN: 2211-1247

JOURNAL ARTICLE

Gil J, Withers DJ, 2016, AGEING Out with the old, NATURE, Vol: 530, Pages: 164-165, ISSN: 0028-0836

JOURNAL ARTICLE

Selman C, Sinclair A, Pedroni SMA, Irvine EE, Michie AM, Withers DJet al., 2016, Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice, ONCOTARGET, Vol: 7, Pages: 29937-29943, ISSN: 1949-2553

JOURNAL ARTICLE

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian Het al., 2016, Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function., Cell Metabolism, Vol: 23, Pages: 821-836, ISSN: 1932-7420

Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strategy for the treatment of obesity and its complications. AMPK is a conserved, ubiquitously expressed, heterotrimeric serine/threonine kinase whose short-term activation has multiple beneficial metabolic effects. Whether these translate into long-term benefits for obesity and its complications is unknown. Here, we observe that mice with chronic AMPK activation, resulting from mutation of the AMPK γ2 subunit, exhibit ghrelin signaling-dependent hyperphagia, obesity, and impaired pancreatic islet insulin secretion. Humans bearing the homologous mutation manifest a congruent phenotype. Our studies highlight that long-term AMPK activation throughout all tissues can have adverse metabolic consequences, with implications for pharmacological strategies seeking to chronically activate AMPK systemically to treat metabolic disease.

JOURNAL ARTICLE

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martinez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gill Jet al., 2015, mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype, NATURE CELL BIOLOGY, Vol: 17, Pages: 1205-+, ISSN: 1465-7392

JOURNAL ARTICLE

Pienaar IS, Gartside SE, Sharma P, De Paola V, Gretenkord S, Withers D, Elson JL, Dexter DTet al., 2015, Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease, MOLECULAR NEURODEGENERATION, Vol: 10, ISSN: 1750-1326

JOURNAL ARTICLE

Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SMA, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJet al., 2015, Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice, Cell Reports, Vol: 11, Pages: 335-343, ISSN: 2211-1247

JOURNAL ARTICLE

Deas E, Piipari K, Machhada A, Li A, Gutierrez-del-Arroyo A, Withers DJ, Wood NW, Abramov AYet al., 2014, PINK1 deficiency in beta-cells increases basal insulin secretion and improves glucose tolerance in mice, OPEN BIOLOGY, Vol: 4, ISSN: 2046-2441

JOURNAL ARTICLE

Jove M, Naudi A, Ramirez-Nunez O, Portero-Otin M, Selman C, Withers DJ, Pamplona Ret al., 2014, Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice, AGING CELL, Vol: 13, Pages: 828-837, ISSN: 1474-9718

JOURNAL ARTICLE

Page MM, Sinclair A, Robb EL, Stuart JA, Withers DJ, Selman Cet al., 2014, Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress, AGING CELL, Vol: 13, Pages: 962-964, ISSN: 1474-9718

JOURNAL ARTICLE

Yousseif A, Emmanuel J, Karra E, Millet Q, Elkalaawy M, Jenkinson AD, Hashemi M, Adamo M, Finer N, Fiennes AG, Withers DJ, Batterham RLet al., 2014, Differential Effects of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass on Appetite, Circulating Acyl-ghrelin, Peptide YY3-36 and Active GLP-1 Levels in Non-diabetic Humans, OBESITY SURGERY, Vol: 24, Pages: 241-252, ISSN: 0960-8923

JOURNAL ARTICLE

Chandarana K, Gelegen C, Irvine EE, Choudhury AI, Amouyal C, Andreelli F, Withers DJ, Batterham RLet al., 2013, Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance, MOLECULAR METABOLISM, Vol: 2, Pages: 142-152, ISSN: 2212-8778

JOURNAL ARTICLE

Foukas LC, Bilanges B, Bettedi L, Pearce W, Ali K, Sancho S, Withers DJ, Vanhaesebroeck Bet al., 2013, Long-term p110 PI3K inactivation exerts a beneficial effect on metabolism, EMBO MOLECULAR MEDICINE, Vol: 5, Pages: 563-571, ISSN: 1757-4676

JOURNAL ARTICLE

Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew ME, Rahman S, Emmanuel JJ, Williams SCR, Ruether UU, Bruening JC, Withers DJ, Zelaya FO, Batterham RLet al., 2013, A link between FTO, ghrelin, and impaired brain food-cue responsivity, JOURNAL OF CLINICAL INVESTIGATION, Vol: 123, Pages: 3539-3551, ISSN: 0021-9738

JOURNAL ARTICLE

Page MM, Withers DJ, Selman C, 2013, Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage, AGE, Vol: 35, Pages: 647-658, ISSN: 0161-9152

JOURNAL ARTICLE

Scott WR, Gelegen C, Chandarana K, Karra E, Yousseif A, Amouyal C, Choudhury AI, Andreelli F, Withers DJ, Batterham RLet al., 2013, Differential Pre-mRNA Splicing Regulates Nnat Isoforms in the Hypothalamus after Gastric Bypass Surgery in Mice, PLOS ONE, Vol: 8, ISSN: 1932-6203

JOURNAL ARTICLE

Costello DA, Claret M, Al-Qassab H, Plattner F, Irvine EE, Choudhury AI, Giese KP, Withers DJ, Pedarzani Pet al., 2012, Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity, PLOS ONE, Vol: 7, ISSN: 1932-6203

JOURNAL ARTICLE

Gelegen C, Chandarana K, Choudhury AI, Al-Qassab H, Evans IM, Irvine EE, Hyde CB, Claret M, Andreelli F, Sloan SE, Leiter AB, Withers DJ, Batterham RLet al., 2012, Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 303, Pages: E659-E668, ISSN: 0193-1849

JOURNAL ARTICLE

Neuhaus B, Niessen CM, Mesaros A, Withers DJ, Krieg T, Partridge Let al., 2012, Experimental analysis of risk factors for ulcerative dermatitis in mice, EXPERIMENTAL DERMATOLOGY, Vol: 21, Pages: 712-713, ISSN: 0906-6705

JOURNAL ARTICLE

Page MM, Withers DJ, Selman C, 2012, An evaluation of cellular stress resistance in long-lived insulin receptor substrate-1 (Irs1) null mice, FREE RADICAL BIOLOGY AND MEDICINE, Vol: 53, Pages: S75-S75, ISSN: 0891-5849

JOURNAL ARTICLE

Wijeyesekera A, Selman C, Barton RH, Holmes E, Nicholson JK, Withers DJet al., 2012, Metabotyping of Long-Lived Mice using H-1 NMR Spectroscopy, JOURNAL OF PROTEOME RESEARCH, Vol: 11, Pages: 2224-2235, ISSN: 1535-3893

JOURNAL ARTICLE

Chandarana K, Gelegen C, Karra E, Choudhury AI, Drew ME, Fauveau V, Viollet B, Andreelli F, Withers DJ, Batterham RLet al., 2011, Diet and Gastrointestinal Bypass-Induced Weight Loss The Roles of Ghrelin and Peptide YY, DIABETES, Vol: 60, Pages: 810-818, ISSN: 0012-1797

JOURNAL ARTICLE

Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJet al., 2011, Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice, DIABETES, Vol: 60, Pages: 735-745, ISSN: 0012-1797

JOURNAL ARTICLE

Irvine EE, Drinkwater L, Radwanska K, Al-Qassab H, Smith MA, O'Brien M, Kielar C, Choudhury AI, Krauss S, Cooper JD, Withers DJ, Giese KPet al., 2011, Insulin receptor substrate 2 is a negative regulator of memory formation, LEARNING & MEMORY, Vol: 18, Pages: 375-383, ISSN: 1072-0502

JOURNAL ARTICLE

Page MM, Withers DJ, Selman C, 2011, Contribution of ROS-Metabolism in Tissue Homogenates and Dermal Fibroblasts of Long-Lived Insulin Receptor Substrate 1 (Irs1) Knockout Mice, 18th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM), Publisher: ELSEVIER SCIENCE INC, Pages: S78-S79, ISSN: 0891-5849

CONFERENCE PAPER

Selman C, Partridge L, Withers DJ, 2011, Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1, PLOS ONE, Vol: 6, ISSN: 1932-6203

JOURNAL ARTICLE

Selman C, Withers DJ, 2011, Mammalian models of extended healthy lifespan, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 366, Pages: 99-107, ISSN: 0962-8436

JOURNAL ARTICLE

Woods A, Heslegrave AJ, Muckett PJ, Levene AP, Clements M, Mobberley M, Ryder TA, Abu-Hayyeh S, Williamson C, Goldin RD, Ashworth A, Withers DJ, Carling Det al., 2011, LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice, BIOCHEMICAL JOURNAL, Vol: 434, Pages: 49-60, ISSN: 0264-6021

JOURNAL ARTICLE

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