Imperial College London

Professor Dan Elson

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Surgical Imaging
 
 
 
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Contact

 

+44 (0)20 7594 1700daniel.elson Website

 
 
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Location

 

415 Bessemer BuildingBessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

377 results found

Singh M, Navabi E, Zhou Y, zhao H, Ma D, Cass A, Hanna G, Elson Det al., Application of Gold Nanorods in Cancer Theranostics (winner SARS/ASiT Prize), Association of Surgeons in Training

Conference paper

Lin J, Clancy NT, Sun X, Qi J, Janatka M, Stoyanov D, Elson DSet al., Hybrid Tissue Surface Hyperspectral imaging and Shape Recovery, Hyperspectral Imaging & Applications Conference

Conference paper

Singh M, Nabavi E, Zhou Y, Gallina M, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., Application of Gold Nanoparticles for Photothermal Therapy of Upper Gastrointestinal Adenocarcinoma, Bio-Nano-Photonics Symposium

Conference paper

Gallina ME, Zhou Y, Johnson CJ, Harris-Birtill D, Singh M, Zhao H, Ma D, Cass T, Elson DSet al., 2015, Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents, Materials Science & Engineering C - Biomimetic and Supramolecular Systems, Vol: 59, Pages: 324-332, ISSN: 0928-4931

GNRs are emerging as a new class of probes for theradiagnostic applications thanks to their unique optical properties. However, the achievement of proper nanoconstructs requires the synthesis of highly pure GNRs with well-defined aspect ratio (AR), in addition to extensive surface chemistry modification to provide them with active targeting and, possibly, multifunctionality.In this work, we refined the method of the seed mediated growth and developed a robust procedure for the fabrication of GNRs with specific AR. We also revealed and characterized unexplored aging phenomena that follow the synthesis and consistently alter GNRs' final AR. Such advances appreciably improved the feasibility of GNRs fabrication and offered useful insights on the growth mechanism.We next produced fluorescent, biocompatible, aptamer-conjugated GNRs by performing ligand exchange followed by bioconjugation to anti-cancer oligonucleotide AS1411. In vitro studies showed that our nanoconstructs selectively target cancer cells while showing negligible cytotoxicity. As a result, our aptamer-conjugated GNRs constitute ideal cancer-selective multifunctional probes and promising candidates as photothermal therapy agents.

Journal article

Clancy NT, Arya S, Stoyanov D, Singh M, Hanna GB, Elson DSet al., 2015, Intraoperative measurement of bowel oxygen saturation using a multispectral imaging laparoscope, Biomedical Optics Express, Vol: 6, Pages: 4179-4190, ISSN: 2156-7085

Intraoperative monitoring of tissue oxygen saturation (StO2) has potentially important applications in procedures such as organ transplantation or colorectal surgery, where successful reperfusion affects the viability and integrity of repaired tissues. In this paper a liquid crystal tuneable filter-based multispectral imaging (MSI) laparoscope is described. Motion-induced image misalignments are reduced, using feature-based registration, before regression of the tissue reflectance spectra to calculate relative quantities of oxy- and deoxyhaemoglobin. The laparoscope was validated in vivo, during porcine abdominal surgery, by making parallel MSI and blood gas measurements of the small bowel vasculature. Ischaemic conditions were induced by local occlusion of the mesenteric arcade and monitored using the system. The MSI laparoscope was capable of measuring StO2 over a wide range (30-100%) with a temporal error of ± 7.5%. The imager showed sensitivity to spatial changes in StO2 during dynamic local occlusions, as well as tracking the recovery of tissues post-occlusion.

Journal article

Elson DS, 2015, Surgical Imaging, Biophotonics and Endoscopy (invited), Optoelectronic Global Conference 2015

Conference paper

Lin J, Clancy NT, Elson DS, 2015, An endoscopic structured light system using multispectral detection., International Journal of Computer Assisted Radiology and Surgery, Vol: 10, Pages: 1941-1950, ISSN: 1861-6410

PURPOSE: In clinical examinations, the tissue surface topology is an important feature for detecting the tissue pathology and implementing augmented reality. We have previously presented a miniaturised structured light (SL) system for recovery of tissue surface shape in minimally invasive surgery (MIS), based on a flexible multispectral structured illumination probe (1.9 mm diameter) (Clancy et al. in Biomed Opt Express 2(11):3119-3128, 2011. doi: 10.1364/BOE.2.003119 ). This paper reports further hardware and analytical developments to improve the light pattern decoding result and increase the reconstruction accuracy. METHODS: The feasibility of using an 8-band multispectral camera with higher pattern-colour discrimination ability than normal RGB camera in this system was studied. Additionally, the "normalised cut" algorithm was investigated to improve pattern segmentation. RESULTS: The whole SL system was evaluated by phantom and in vivo experiments. Higher pattern identification performance than that of an RGB camera was recorded by using the multispectral camera (average precision >97 %, average sensitivity >62 %). An average of [Formula: see text] reconstruction error was achieved using the proposed pattern decoding method on a heart phantom at a working distance of approximately 10 cm. CONCLUSIONS: The experiment showed the superiority of the multispectral camera over the RGB camera in the spot identification step. The proposed pattern decoding algorithm underwent evaluations using different experiments, showing that it provided promising reconstruction results. The potential of using this system in MIS environments has been demonstrated.

Journal article

Clancy NT, Arya S, Stoyanov D, Du X, Hanna GB, Elson DSet al., 2015, Imaging the spectral reflectance properties of bipolar radiofrequency-fused bowel tissue, Conference on Clinical and Biomedical Spectroscopy and Imaging IV held at the European Conferences on Biomedical Optics, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, Pages: 953717-1-953717-6, ISSN: 0277-786X

Delivery of radiofrequency (RF) electrical energy is used during surgery to heat and seal tissue, such as vessels, allowing resection without blood loss. Recent work has suggested that this approach may be extended to allow surgical attachment of larger tissue segments for applications such as bowel anastomosis.In a large series of porcine surgical procedures bipolar RF energy was used to resect and re-seal the small bowel in vivo with a commercial tissue fusion device (Ligasure; Covidien PLC, USA). The tissue was then imaged with a multispectral imaging laparoscope to obtain a spectral datacube comprising both fused and healthy tissue. Maps of blood volume, oxygen saturation and scattering power were derived from the measured reflectance spectra using an optimised light-tissue interaction model.A 60% increase in reflectance of visible light (460-700 nm) was observed after fusion, with the tissue taking on a white appearance. Despite this the distinctive shape of the haemoglobin absorption spectrum was still noticeable in the 460-600 nm wavelength range. Scattering power increased in the fused region in comparison to normal serosa, while blood volume and oxygen saturation decreased.Observed fusion-induced changes in the reflectance spectrum are consistent with the biophysical changes induced through tissue denaturation and increased collagen cross-linking. The multispectral imager allows mapping of the spatial extent of these changes and classification of the zone of damaged tissue. Further analysis of the spectral data in parallel with histopathological examination of excised specimens will allow correlation of the optical property changes with microscopic alterations in tissue structure. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Conference paper

Du X, Clancy N, Arya S, Hanna GB, Kelly J, Elson DS, Stoyanov Det al., 2015, Robust surface tracking combining features, intensity and illumination compensation, International Journal of Computer Assisted Radiology and Surgery, Vol: 10, Pages: 1915-1926, ISSN: 1861-6410

Purpose Recovering tissue deformation during robotic-assisted minimally invasivesurgery (MIS) procedures is important for providing intra-operative guidance,enabling in vivo imaging modalities and enhanced robotic control. The tissue motioncan also be used to apply motion stabilization and to prescribe dynamicconstraints for avoiding critical anatomical structures.Methods Image-based methods based independently on salient features or onimage intensity have limitations when dealing with homogeneous soft-tissues orcomplex reflectance. In this paper, we use a triangular geometric mesh model inorder to combine the advantages of both feature and intensity information andtrack the tissue surface reliably and robustly.Results Synthetic and in vivo experiments are performed to provide quantitativeanalysis of the tracking accuracy of our method, we also show exemplar results forregistering multispectral images where there is only a weak image signal.Conclusions Compared to traditional methods, our hybrid tracking method ismore robust and has improved convergence in the presence of larger displacements,tissue dynamics and illumination changes.

Journal article

Singh M, Harris-Birtill DCC, Markar SR, Hanna GB, Elson DSet al., 2015, Application of Gold Nanoparticles for Gastrointestinal Cancer Theranostics: A Systematic Review., Nanomedicine: Nanotechnology, Biology, and Medicine, Vol: 11, Pages: 2083-2098, ISSN: 1549-9634

Gold nanoparticles (GNPs) are readily synthesised structures that absorb light strongly to generate thermal energy which induces photothermal destruction of malignant tissue. This review examines the efficacy, potential challenges and toxicity from in vitro and in vivo applications of GNPs in oesophageal, gastric and colon cancers. A systematic literature search of Medline, Embase, Web of Science and Cochrane databases was performed using PRISMA guidelines. Two hundred and eighty-four papers were reviewed with sixteen studies meeting the inclusion criteria. The application of GNPs in eleven in vivo rodent studies with GI adenocarcinoma demonstrated excellent therapeutic outcomes but poor corroboration in terms of the cancer cells used, photothermal irradiation regimes, fluorophores and types of nanoparticles. There is compelling evidence of the translational potential of GNPs to be complimentary to surgery and feasible in the photothermal therapy of GI cancer but reproducibility and standardisation require further development prior to GI cancer clinical trials.

Journal article

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass AE, Hanna GB, Elson DSet al., 2015, APPLICATION OF GOLD NANORODS FOR IN VIVO THERANOSTICS OF HUMAN OESOPHAGEAL ADENOCARCINOMA, 2nd Digestive-Disorders-Federation Conference, Publisher: BMJ PUBLISHING GROUP, Pages: A471-A471, ISSN: 0017-5749

Conference paper

Thum MY, Saso S, Clancy N, Smith JRet al., 2015, Imaging of organ viability during uterine transplantation surgery, 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 34-34, ISSN: 0268-1161

Conference paper

Li S, Cheng Y, Eckersley RJ, Elson DS, Tang M-Xet al., 2015, Dual shear wave induced laser speckle contrast signal and the improvement in shear wave speed measurement, Biomedical Optics Express, Vol: 6, Pages: 1954-1962, ISSN: 2156-7085

Shear wave speed is quantitatively related to tissue viscoelasticity.Previously we reported shear wave tracking at centimetre depths ina turbid optical medium using laser speckle contrast detection. Shear waveprogression modulates displacement of optical scatterers and therefore modulatesphoton phase and changes the laser speckle patterns. Time-resolvedcharge-coupled device (CCD)-based speckle contrast analysis was used totrack shear waves and measure the time-of-flight of shear waves for speedmeasurement. In this manuscript, we report a new observation of the laserspeckle contrast difference signal for dual shear waves. A modulation ofCCD speckle contrast difference was observed and simulation reproducesthe modulation pattern, suggesting its origin. Both experimental andsimulation results show that the dual shear wave approach generates animproved definition of temporal features in the time-of-flight optical signaland an improved signal to noise ratio with a standard deviation less than50% that of individual shear waves. Results also show that dual shear wavescan correct the bias of shear wave speed measurement caused by shear wavereflections from elastic boundaries.

Journal article

Williams P, Arya S, Wei R, Chalau V, Haris-Birtill D, Kudo H, Goldin RD, Elson DS, Hanna GBet al., 2015, Radiofrequency induced small bowel thermofusion: a study of serosa-to-serosa seal adequacy using mechanical and imaging modalities, Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, Publisher: WILEY-BLACKWELL, Pages: 33-33, ISSN: 0007-1323

Conference paper

Arya S, Chalau V, Singh M, Clancy NT, Kudo H, Goldin RD, Elson DS, Hanna GBet al., 2015, Bipolar radiofrequency energy as a novel method of bowel anastomosis: results of a comparative animal study, Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, Publisher: WILEY-BLACKWELL, Pages: 38-38, ISSN: 0007-1323

Conference paper

Wei R, Arya S, Williams P, Chalau V, Harris-Birtill D, Kudo H, Goldin RD, Elson DS, Hanna GBet al., 2015, Therma response during ex vivo mucosa-to-mucosa bipolar radiofrequency induced intestinal sealing, Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, Publisher: WILEY-BLACKWELL, Pages: 40-40, ISSN: 0007-1323

Conference paper

Avila Rencoret FB, Elson DS, Mylonas G, 2015, Probe Deployment Device

Patent

Tatla T, Podoleanu A, Elson DS, 2015, Optical Diagnostics in Head and Neck Cancer, Recent Advances in Otolaryngology: 9, Publisher: JP Medical Ltd, ISBN: 9781907816895

Recent Advances in Otolaryngology: 9 provides a selection of review articles that present important advances within the field of ENT medicine.

Book chapter

Tziraki M, Song L, Elson DS, 2015, An endoscopic multi-exposure laser speckle contrast analysis system for blood flow and microcirculation measurements, SPIE BiOS conference on Optical Elastography and Tissue Biomechanics II, Publisher: SPIE, ISSN: 0277-786X

Conference paper

Clancy NT, Lin J, Arya S, Hanna GB, Elson DSet al., 2015, Dual multispectral and 3D structured light laparoscope, Conference on Multimodal Biomedical Imaging X, Publisher: SPIE, ISSN: 0277-786X

Conference paper

Lin J, Clancy NT, Stoyanov D, Elson DSet al., 2015, Tissue Surface Reconstruction Aided by Local Normal Information Using a Self-calibrated Endoscopic Structured Light System, 18th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Publisher: SPRINGER INTERNATIONAL PUBLISHING AG, Pages: 405-412, ISSN: 0302-9743

Conference paper

Pigula A, Clancy NT, Arya S, Hanna GB, Elson DSet al., 2015, Video-rate dual polarization multispectral endoscopic imaging, Conference on Biomedical Applications of Light Scattering IX, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

Conference paper

Elson DS, Surgical Imaging, Biophotonics and Endoscopy (keynote), International Conference on Biomedical Engineering and Biophysics

Conference paper

Harris-Birtill D, Singh M, Zhou YU, Shah A, Gallina M, Cass A, Bamber J, Hanna G, Elson DSet al., Gold Nanorod Reshaping using a Continuous Wave Laser, Bio-Nano-Photonics Symposium

Conference paper

Lin J, Clancy NT, Elson DS, An endoscopic structured light system using multispectral detection, International Conference on Information Processing and Computer Assisted Interventions

Conference paper

Nabavi E, Singh M, Zhou Y, Gallina M, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., Preliminary studies of targeted NIR photothermal therapy of human oesophageal adenocarcinoma in mice using multifunctional GNRs, British Medical Laser Association Conference

Conference paper

Qi J, Singh M, Pigula A, Clancy N, Elson DSet al., Rigid endoscopic polarimetric wide-field imaging (invited), SPIE BiOS Molecular-Guided Surgery

Conference paper

Saso S, Clancy N, Jones B, Al-Memar M, Bracewell-Milnes T, Thum M, Bourne T, Elson DS, Smith Jet al., Assessing uterine graft viability using multispectral imaging during uterine transplantation, 25th World Congress on Ultrasound in Obstetrics and Gynecology

Conference paper

Saso S, Clancy N, Tziraki M, Jones B, Al-Memar M, Bracewell-Milnes T, Thum M, Bourne T, Elson DS, Smith Jet al., Use of endoscopic laser speckle contrast analysis to assess uterine perfusion and blood flow in a uterine transplantation model, 25th World Congress on Ultrasound in Obstetrics and Gynecology

Conference paper

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., Application of Gold Nanorods for Upper Gastrointestinal Cancer Theranostics (first prize), 9th London Surgical Symposium & the 68th Simpson Smith Lecture and Awards

Conference paper

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