Imperial College London

Professor Dan Elson

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Surgical Imaging
 
 
 
//

Contact

 

+44 (0)20 7594 1700daniel.elson Website

 
 
//

Location

 

415 Bessemer BuildingBessemer BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Singh:2015:10.1016/j.nano.2015.05.010,
author = {Singh, M and Harris-Birtill, DCC and Markar, SR and Hanna, GB and Elson, DS},
doi = {10.1016/j.nano.2015.05.010},
journal = {Nanomedicine: Nanotechnology, Biology, and Medicine},
pages = {2083--2098},
title = {Application of Gold Nanoparticles for Gastrointestinal Cancer Theranostics: A Systematic Review.},
url = {http://dx.doi.org/10.1016/j.nano.2015.05.010},
volume = {11},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Gold nanoparticles (GNPs) are readily synthesised structures that absorb light strongly to generate thermal energy which induces photothermal destruction of malignant tissue. This review examines the efficacy, potential challenges and toxicity from in vitro and in vivo applications of GNPs in oesophageal, gastric and colon cancers. A systematic literature search of Medline, Embase, Web of Science and Cochrane databases was performed using PRISMA guidelines. Two hundred and eighty-four papers were reviewed with sixteen studies meeting the inclusion criteria. The application of GNPs in eleven in vivo rodent studies with GI adenocarcinoma demonstrated excellent therapeutic outcomes but poor corroboration in terms of the cancer cells used, photothermal irradiation regimes, fluorophores and types of nanoparticles. There is compelling evidence of the translational potential of GNPs to be complimentary to surgery and feasible in the photothermal therapy of GI cancer but reproducibility and standardisation require further development prior to GI cancer clinical trials.
AU - Singh,M
AU - Harris-Birtill,DCC
AU - Markar,SR
AU - Hanna,GB
AU - Elson,DS
DO - 10.1016/j.nano.2015.05.010
EP - 2098
PY - 2015///
SN - 1549-9634
SP - 2083
TI - Application of Gold Nanoparticles for Gastrointestinal Cancer Theranostics: A Systematic Review.
T2 - Nanomedicine: Nanotechnology, Biology, and Medicine
UR - http://dx.doi.org/10.1016/j.nano.2015.05.010
UR - http://hdl.handle.net/10044/1/24152
VL - 11
ER -